{"id":"clotiapine","rwe":[{"pmid":"39460225","year":"2024","title":"Decorated Electrode Surfaces with Nanostructures and Metal-Organic Frameworks as Transducers for Sensing.","finding":"","journal":"Sensors (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"37391310","year":"2024","title":"A brief history of clozapine use in Taiwan.","finding":"","journal":"Schizophrenia research","studyType":"Clinical Study"},{"pmid":"36551922","year":"2022","title":"Antipsychotics in the Treatment of Children and Adolescents with Anorexia Nervosa: A Systematic Review.","finding":"","journal":"Biomedicines","studyType":"Clinical Study"},{"pmid":"36200467","year":"2022","title":"Buprenorphine/naloxone (Suboxone®) withdrawal may facilitate antipsychotic-induced priapism. A case report.","finding":"","journal":"Rivista di psichiatria","studyType":"Clinical Study"},{"pmid":"35180813","year":"2022","title":"Prevalence and Risk Factors for QTc Prolongation in Acute Psychiatric Hospitalization.","finding":"","journal":"The primary care companion for CNS disorders","studyType":"Clinical Study"}],"tags":[{"label":"clotiapine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"D(2) dopamine receptor","category":"target"},{"label":"DRD2","category":"gene"},{"label":"N05AH06","category":"atc"},{"label":"Active","category":"status"},{"label":"Antipsychotic Agents","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Central Nervous System Depressants","category":"pharmacology"},{"label":"Psychotropic Drugs","category":"pharmacology"},{"label":"Tranquilizing Agents","category":"pharmacology"}],"phase":"unknown","safety":{"safetySignals":[{"llr":429.494,"date":"","count":101,"signal":"Sopor","source":"DrugCentral FAERS","actionTaken":"Reported 101 times (LLR=429)"},{"llr":348.442,"date":"","count":122,"signal":"Drug abuse","source":"DrugCentral FAERS","actionTaken":"Reported 122 times (LLR=348)"},{"llr":120.335,"date":"","count":81,"signal":"Toxicity to various agents","source":"DrugCentral FAERS","actionTaken":"Reported 81 times (LLR=120)"},{"llr":106.334,"date":"","count":35,"signal":"Intentional self-injury","source":"DrugCentral FAERS","actionTaken":"Reported 35 times (LLR=106)"},{"llr":85.462,"date":"","count":27,"signal":"Sudden death","source":"DrugCentral FAERS","actionTaken":"Reported 27 times (LLR=85)"},{"llr":85.407,"date":"","count":39,"signal":"Depressed level of consciousness","source":"DrugCentral FAERS","actionTaken":"Reported 39 times (LLR=85)"},{"llr":68.03,"date":"","count":35,"signal":"Intentional overdose","source":"DrugCentral FAERS","actionTaken":"Reported 35 times (LLR=68)"},{"llr":65.134,"date":"","count":32,"signal":"Suicide attempt","source":"DrugCentral FAERS","actionTaken":"Reported 32 times (LLR=65)"},{"llr":64.249,"date":"","count":33,"signal":"Coma","source":"DrugCentral FAERS","actionTaken":"Reported 33 times (LLR=64)"}],"commonSideEffects":[{"effect":"Sopor","drugRate":"LLR 429","severity":"common"},{"effect":"Drug abuse","drugRate":"LLR 348","severity":"common"},{"effect":"Toxicity to various agents","drugRate":"LLR 120","severity":"common"},{"effect":"Intentional self-injury","drugRate":"LLR 106","severity":"common"},{"effect":"Sudden death","drugRate":"LLR 85","severity":"common"},{"effect":"Depressed level of consciousness","drugRate":"LLR 85","severity":"common"},{"effect":"Suicide attempt","drugRate":"LLR 65","severity":"common"},{"effect":"Coma","drugRate":"LLR 64","severity":"common"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"_fixedAt":"2026-03-30T16:47:48.793432","allNames":"entumine","offLabel":[],"synonyms":["clothiapine","clothiapin","clotiapine","entumine"],"timeline":[],"approvals":[],"brandName":"Entumine","ecosystem":[],"mechanism":{"target":"D(2) dopamine receptor, D(1A) dopamine receptor, D(2) dopamine receptor","targets":[{"gene":"DRD2","source":"DrugCentral","target":"D(2) dopamine receptor","protein":"D(2) dopamine receptor","isPrimary":true,"activityType":"Ki","activityValue":9.31}],"modality":"Small Molecule","drugClass":"clotiapine","explanation":"Think of dopamine like a messenger in your brain that helps you feel pleasure and motivation. When there's too much dopamine, it can lead to problems like psychosis or schizophrenia. Entumine helps by blocking the receptors that dopamine binds to, which can help calm down the abnormal activity and reduce symptoms.","oneSentence":"Entumine works by blocking the D(2) dopamine receptor, which can help regulate abnormal dopamine activity in the brain.","technicalDetail":"Clotiapine acts as a selective antagonist at the D(2) dopamine receptor, which is a subtype of dopamine receptor that plays a key role in regulating dopamine activity in the brain."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Clotiapine","title":"Clotiapine","extract":"Clotiapine (Entumine) is an atypical antipsychotic of the dibenzothiazepine chemical class. It was first introduced in a few European countries, Argentina, Taiwan and Israel in 1970."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/717","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=clotiapine","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=clotiapine","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://en.wikipedia.org/wiki/Clotiapine","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T10:14:00.446737","biosimilars":[],"competitors":[{"drugName":"loxapine","drugSlug":"loxapine","fdaApproval":"1975-02-25","patentExpiry":"Oct 23, 2026","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"clozapine","drugSlug":"clozapine","fdaApproval":"1989-09-26","patentExpiry":"May 1, 2028","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"olanzapine","drugSlug":"olanzapine","fdaApproval":"1996-09-30","genericCount":34,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"quetiapine","drugSlug":"quetiapine","fdaApproval":"1997-09-26","genericCount":27,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"asenapine","drugSlug":"asenapine","fdaApproval":"2009-08-13","patentExpiry":"Sep 22, 2033","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"samidorphan","drugSlug":"samidorphan","fdaApproval":"2021-05-28","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"clotiapine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"_fixedFields":["primaryTarget"],"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"loxapine","brandName":"loxapine","genericName":"loxapine","approvalYear":"1975","relationship":"same-class"},{"drugId":"clozapine","brandName":"clozapine","genericName":"clozapine","approvalYear":"1989","relationship":"same-class"},{"drugId":"olanzapine","brandName":"olanzapine","genericName":"olanzapine","approvalYear":"1996","relationship":"same-class"},{"drugId":"quetiapine","brandName":"quetiapine","genericName":"quetiapine","approvalYear":"1997","relationship":"same-class"},{"drugId":"asenapine","brandName":"asenapine","genericName":"asenapine","approvalYear":"2009","relationship":"same-class"},{"drugId":"samidorphan","brandName":"samidorphan","genericName":"samidorphan","approvalYear":"2021","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT01765829","phase":"PHASE3","title":"Clinical Trial to Evaluate the Efficacy of Treatment vs Discontinuation in a First Episode of Non-affective Psychosis","status":"UNKNOWN","sponsor":"Fundación Pública Andaluza Progreso y Salud","startDate":"2012-11","conditions":["Psychosis Nos/Other"],"enrollment":104,"completionDate":"2015-11"},{"nctId":"NCT01323205","phase":"PHASE2","title":"Investigation of the Safety, Tolerability and Potential Therapeutic Effects of JNJ-40411813 in Patients With Schizophrenia","status":"COMPLETED","sponsor":"Janssen Research & Development, LLC","startDate":"2011-05","conditions":["Schizophrenia"],"enrollment":100,"completionDate":"2012-12"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"006953","UNII":"Z05HCY0X1T","CHEBI":"CHEBI:31424","INN_ID":"2136","RXNORM":"2620","UMLSCUI":"C0009071","ChEMBL_ID":"CHEMBL304902","KEGG_DRUG":"D01597","DRUGBANK_ID":"DB13256","PUBCHEM_CID":"16351","SNOMEDCT_US":"698028004","MESH_SUPPLEMENTAL_RECORD_UI":"C084602"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":56,"therapeuticAreas":["Neuroscience"],"atcClassification":{"source":"DrugCentral","atcCode":"N05AH06","allCodes":["N05AH06"]},"biosimilarFilings":[],"recentPublications":[{"date":"2024 Oct 20","pmid":"39460225","title":"Decorated Electrode Surfaces with Nanostructures and Metal-Organic Frameworks as Transducers for Sensing.","journal":"Sensors (Basel, Switzerland)"},{"date":"2024 Jun","pmid":"37391310","title":"A brief history of clozapine use in Taiwan.","journal":"Schizophrenia research"},{"date":"2022 Dec 7","pmid":"36551922","title":"Antipsychotics in the Treatment of Children and Adolescents with Anorexia Nervosa: A Systematic Review.","journal":"Biomedicines"},{"date":"2022 Sep-Oct","pmid":"36200467","title":"Buprenorphine/naloxone (Suboxone®) withdrawal may facilitate antipsychotic-induced priapism. A case report.","journal":"Rivista di psichiatria"},{"date":"2022 Feb 17","pmid":"35180813","title":"Prevalence and Risk Factors for QTc Prolongation in Acute Psychiatric Hospitalization.","journal":"The primary care companion for CNS disorders"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Entumine (clotiapine) is a small molecule drug that targets the D(2) dopamine receptor. It is classified as a clotiapine, but its commercial status and approved indications are unknown. Entumine is not FDA-approved, and its half-life, bioavailability, and generic manufacturers are also unknown. As a result, its availability and safety profile are unclear. Further research is needed to determine its potential therapeutic applications and risks.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":false,"safety":true,"trials":true,"score":3}}