{"id":"clostridium-butyricum-capsules","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbance"},{"rate":null,"effect":"Abdominal discomfort"},{"rate":null,"effect":"Flatulence"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Clostridium butyricum is a spore-forming bacterium that colonizes the gut and ferments dietary fiber to produce short-chain fatty acids, particularly butyrate. Butyrate serves as a primary energy source for colonocytes, strengthens the intestinal epithelial barrier, and modulates immune responses through histone deacetylase inhibition and G-protein coupled receptor signaling. This mechanism helps restore dysbiotic microbiota and improve gastrointestinal health.","oneSentence":"Clostridium butyricum is a live biotherapeutic agent that produces butyrate in the colon to promote beneficial microbiota composition and intestinal barrier function.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:41:01.716Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Diarrhea associated with dysbiosis"},{"name":"Irritable bowel syndrome"},{"name":"Inflammatory bowel conditions"}]},"trialDetails":[{"nctId":"NCT07263880","phase":"PHASE1, PHASE2","title":"Clostridium Butyricum in Stenosing Crohn's Desease","status":"NOT_YET_RECRUITING","sponsor":"San Giovanni Addolorata Hospital","startDate":"2025-12-01","conditions":"Crohn Disease (CD)","enrollment":40},{"nctId":"NCT07167342","phase":"PHASE4","title":"The Effect of Oral Clostridium Butyricum on the Recurrence After Colonoscopic Resection of Colorectal 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agent that produces butyrate in the colon to promote beneficial microbiota composition and intestinal barrier function. Used for Diarrhea associated with dysbiosis, Irritable bowel syndrome, Inflammatory bowel conditions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}