{"id":"clostebol","rwe":[{"pmid":"40955777","year":"2025","title":"Clostebol Metabolism by Different Routes of Administration: Selection of Diagnostic Urinary Markers.","finding":"","journal":"Drug testing and analysis","studyType":"Clinical Study"},{"pmid":"40675174","year":"2026","title":"Transdermal Uptake of Substances Banned in Sports and Its Relevance for Doping Controls.","finding":"","journal":"International journal of sports medicine","studyType":"Clinical Study"},{"pmid":"40675078","year":"2025","title":"Nanostructure-enhanced Raman spectroscopy for sensitive and on-site monitoring of anabolic-androgenic steroids in food and drug products.","finding":"","journal":"Food chemistry","studyType":"Clinical Study"},{"pmid":"40205971","year":"2025","title":"Clostebol detection after transdermal and transmucosal contact. A systematic review.","finding":"","journal":"Clinical chemistry and laboratory medicine","studyType":"Clinical Study"},{"pmid":"39776689","year":"2024","title":"Determination of clostebol residues in the urine of slaughter animals using liquid chromatography-tandem mass spectrometry.","finding":"","journal":"Journal of veterinary research","studyType":"Clinical Study"}],"tags":[{"label":"clostebol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"cholostebol","offLabel":[],"synonyms":["clostebol","chlortestosterone","cholostebol"],"timeline":[],"approvals":[],"brandName":"Cholostebol","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"clostebol","explanation":"Think of it like a key fitting into a lock. Clostebol is the key, and the androgen receptors are the lock. When clostebol binds to the lock, it triggers a series of chemical reactions that ultimately lead to the development of male characteristics, such as increased muscle mass and bone density.","oneSentence":"Clostebol works by binding to androgen receptors in the body, mimicking the effects of testosterone.","technicalDetail":"Clostebol exerts its effects by binding to the androgen receptor (AR), a nuclear receptor that regulates gene expression in response to androgens like testosterone. This binding event triggers a conformational change in the AR, allowing it to translocate to the nucleus and regulate the expression of target genes involved in muscle growth and development."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3112","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CLOSTEBOL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:13:51.427421","biosimilars":[],"competitors":[],"genericName":"clostebol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"005795","UNII":"Z7D4G976SH","CHEBI":"CHEBI:135372","INN_ID":"2601","RXNORM":"61686","UMLSCUI":"C0172467","ChEMBL_ID":"CHEMBL2106571","KEGG_DRUG":"D07731","DRUGBANK_ID":"DB01521","PUBCHEM_CID":"68947","SNOMEDCT_US":"96345002","MESH_SUPPLEMENTAL_RECORD_UI":"C076775"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":31,"therapeuticAreas":["Bone"],"biosimilarFilings":[],"recentPublications":[{"date":"2025 Dec","pmid":"40955777","title":"Clostebol Metabolism by Different Routes of Administration: Selection of Diagnostic Urinary Markers.","journal":"Drug testing and analysis"},{"date":"2026 Feb","pmid":"40675174","title":"Transdermal Uptake of Substances Banned in Sports and Its Relevance for Doping Controls.","journal":"International journal of sports medicine"},{"date":"2025 Nov 15","pmid":"40675078","title":"Nanostructure-enhanced Raman spectroscopy for sensitive and on-site monitoring of anabolic-androgenic steroids in food and drug products.","journal":"Food chemistry"},{"date":"2025 Jul 28","pmid":"40205971","title":"Clostebol detection after transdermal and transmucosal contact. A systematic review.","journal":"Clinical chemistry and laboratory medicine"},{"date":"2024 Dec","pmid":"39776689","title":"Determination of clostebol residues in the urine of slaughter animals using liquid chromatography-tandem mass spectrometry.","journal":"Journal of veterinary research"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cholesteryl ester transfer protein (CETP) inhibitors, also known as cholesteryl ester transfer protein inhibitors or CETP inhibitors, are small molecule drugs that target the cholesteryl ester transfer protein.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}