{"id":"clortermine","rwe":[{"pmid":"2709326","year":"1989","title":"Effects of anorectic drugs on the topography of feeding behavior in baboons.","finding":"","journal":"The Journal of pharmacology and experimental therapeutics","studyType":"Clinical Study"},{"pmid":"2891839","year":"1987","title":"Discriminative stimulus properties of intragastrically administered d-amphetamine and pentobarbital in rhesus monkeys.","finding":"","journal":"The Journal of pharmacology and experimental therapeutics","studyType":"Clinical Study"},{"pmid":"2885408","year":"1987","title":"Amphetamine-like effects of anorectics and related compounds in pigeons.","finding":"","journal":"The Journal of pharmacology and experimental therapeutics","studyType":"Clinical Study"},{"pmid":"3620005","year":"1987","title":"Anorectics: effects on food intake and self-administration in rhesus monkeys.","finding":"","journal":"Alcohol and drug research","studyType":"Clinical Study"},{"pmid":"826970","year":"1976","title":"Comparison of behavior maintained by infusions of eight phenylethylamines in baboons.","finding":"","journal":"Psychopharmacology","studyType":"Clinical Study"}],"tags":[{"label":"clortermine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Anorexia nervosa","category":"indication"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"chlortermine","offLabel":[],"synonyms":["clortermine hydrochloride","clortermine","chlortermine","o-Chlorophentermine","clortermine HCl"],"timeline":[],"approvals":[],"brandName":"Chlortermine","ecosystem":[{"indication":"Anorexia nervosa","otherDrugs":[],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"clortermine","explanation":"In simple terms, Chlortermine helps people with anorexia nervosa feel hungrier and want to eat more. This is achieved by affecting the brain's appetite centers, which can help restore a healthy weight and reduce the risk of related health problems. By increasing food intake, Chlortermine can help individuals with anorexia nervosa recover from their condition.","oneSentence":"Chlortermine works by increasing appetite and food intake in individuals with anorexia nervosa.","technicalDetail":"Chlortermine is believed to exert its effects through interaction with the brain's serotonin and dopamine systems, which play a crucial role in regulating appetite and food intake."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/715","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CLORTERMINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:13:41.722102","biosimilars":[],"competitors":[],"genericName":"clortermine","indications":{"approved":[{"name":"Anorexia nervosa","source":"DrugCentral","snomedId":56882008,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"001875","UNII":"4FA88HM3IX","CHEBI":"CHEBI:134826","INN_ID":"2725","UMLSCUI":"C0771259","ChEMBL_ID":"CHEMBL1697833","KEGG_DRUG":"D03566","DRUGBANK_ID":"DB01527","PUBCHEM_CID":"25223","SECONDARY_CAS_RN":"10389-72-7"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":6,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"1989 Apr","pmid":"2709326","title":"Effects of anorectic drugs on the topography of feeding behavior in baboons.","journal":"The Journal of pharmacology and experimental therapeutics"},{"date":"1987 Dec","pmid":"2891839","title":"Discriminative stimulus properties of intragastrically administered d-amphetamine and pentobarbital in rhesus monkeys.","journal":"The Journal of pharmacology and experimental therapeutics"},{"date":"1987 Jun","pmid":"2885408","title":"Amphetamine-like effects of anorectics and related compounds in pigeons.","journal":"The Journal of pharmacology and experimental therapeutics"},{"date":"1987","pmid":"3620005","title":"Anorectics: effects on food intake and self-administration in rhesus monkeys.","journal":"Alcohol and drug research"},{"date":"1976 Nov 24","pmid":"826970","title":"Comparison of behavior maintained by infusions of eight phenylethylamines in baboons.","journal":"Psychopharmacology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Chlortermine, also known as CLORTERMINE, is a small molecule drug in the clortermine class. It is used to treat anorexia nervosa, a serious eating disorder. The commercial status of Chlortermine is currently unknown, and it is not clear if it is patented or available as a generic medication. Further information on its pharmacokinetics and safety profile is also lacking. As a result, its use should be approached with caution.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}