{"id":"clorprenaline","rwe":[{"pmid":"41176858","year":"2026","title":"Deep learning-assisted surface-enhanced Raman spectroscopy detection of stimulants.","finding":"","journal":"Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy","studyType":"Clinical Study"},{"pmid":"39142772","year":"2024","title":"Ultrasound probe enhanced enzymatic hydrolysis for rapid separation of β(2)-adrenergic agonists from animal urine and livestock wastewater: Applicability to biomonitoring investigation.","finding":"","journal":"Analytica chimica acta","studyType":"Clinical Study"},{"pmid":"38917653","year":"2024","title":"Screening for promising multi-target bioactive components from Cortex Mori Radicis for the treatment of chronic cor pulmonale based on immobilized beta(1)-adrenergic receptor and beta(2)-adrenergic receptor chromatography.","finding":"","journal":"Journal of chromatography. B, Analytical technologies in the biomedical and life sciences","studyType":"Clinical Study"},{"pmid":"38772203","year":"2024","title":"Determination of 13 potential anti-obesity agents in hair by dispersive liquid-liquid microextraction-assisted UHPLC-MS/MS.","finding":"","journal":"Journal of pharmaceutical and biomedical analysis","studyType":"Clinical Study"},{"pmid":"38093540","year":"2023","title":"[Determination of 14 β-agonists in animal meat by ultra high performance liquid chromatography-tandem mass spectrometry].","finding":"","journal":"Se pu = Chinese journal of chromatography","studyType":"Clinical Study"}],"tags":[{"label":"clorprenaline","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Beta-2 adrenergic receptor","category":"target"},{"label":"ADRB2","category":"gene"},{"label":"ADRB1","category":"gene"},{"label":"Active","category":"status"},{"label":"Anti-Asthmatic Agents","category":"pharmacology"},{"label":"Bronchodilator Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Respiratory System Agents","category":"pharmacology"},{"label":"Sympathomimetics","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"isoprofenamine","offLabel":[],"synonyms":["clorprenaline","isoprofenamine","isoprophenamine","clorprenaline hydrochloride","clorprenaline HCl"],"timeline":[],"approvals":[],"brandName":"Isoprofenamine","ecosystem":[],"mechanism":{"target":"Beta-1 adrenergic receptor, Beta-2 adrenergic receptor","targets":[{"gene":"ADRB2","source":"DrugCentral","target":"Beta-2 adrenergic receptor","protein":"Beta-2 adrenergic receptor"},{"gene":"ADRB1","source":"DrugCentral","target":"Beta-1 adrenergic receptor","protein":"Beta-1 adrenergic receptor"}],"modality":"Small Molecule","drugClass":"clorprenaline","explanation":"Imagine your airways are like narrow roads. When you breathe, air has to squeeze through these roads. Isoprofenamine helps widen these roads by stimulating the beta-2 receptors, making it easier for air to flow in and out of your lungs.","oneSentence":"Isoprofenamine works by stimulating the beta-2 receptors in the body, leading to bronchodilation and increased airway resistance.","technicalDetail":"Isoprofenamine acts as a selective agonist at the beta-2 adrenergic receptor, activating the Gs protein and increasing intracellular cAMP levels, which leads to relaxation of smooth muscle cells in the airway walls and subsequent bronchodilation."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/714","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CLORPRENALINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:13:32.533587","biosimilars":[],"competitors":[{"drugName":"acebutolol","drugSlug":"acebutolol","fdaApproval":"1984-12-28","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"amiodarone","drugSlug":"amiodarone","fdaApproval":"1985-12-24","patentExpiry":"Mar 13, 2029","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"arbutamine","drugSlug":"arbutamine","fdaApproval":"1997-09-12","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"arformoterol","drugSlug":"arformoterol","fdaApproval":"2006-10-06","genericCount":17,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"aripiprazole","drugSlug":"aripiprazole","fdaApproval":"2002-11-15","patentExpiry":"Sep 24, 2033","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"asenapine","drugSlug":"asenapine","fdaApproval":"2009-08-13","patentExpiry":"Sep 22, 2033","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"astemizole","drugSlug":"astemizole","fdaApproval":"1988-12-31","relationship":"same-target"},{"drugName":"atenolol","drugSlug":"atenolol","fdaApproval":"1981-08-19","genericCount":22,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"betaxolol","drugSlug":"betaxolol","fdaApproval":"1985-08-30","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"bisoprolol","drugSlug":"bisoprolol","fdaApproval":"1992-07-31","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"clorprenaline","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"acebutolol","brandName":"acebutolol","genericName":"acebutolol","approvalYear":"1984","relationship":"same-target"},{"drugId":"amiodarone","brandName":"amiodarone","genericName":"amiodarone","approvalYear":"1985","relationship":"same-target"},{"drugId":"arbutamine","brandName":"arbutamine","genericName":"arbutamine","approvalYear":"1997","relationship":"same-target"},{"drugId":"arformoterol","brandName":"arformoterol","genericName":"arformoterol","approvalYear":"2006","relationship":"same-target"},{"drugId":"aripiprazole","brandName":"aripiprazole","genericName":"aripiprazole","approvalYear":"2002","relationship":"same-target"},{"drugId":"asenapine","brandName":"asenapine","genericName":"asenapine","approvalYear":"2009","relationship":"same-target"},{"drugId":"astemizole","brandName":"astemizole","genericName":"astemizole","approvalYear":"1988","relationship":"same-target"},{"drugId":"atenolol","brandName":"atenolol","genericName":"atenolol","approvalYear":"1981","relationship":"same-target"},{"drugId":"betaxolol","brandName":"betaxolol","genericName":"betaxolol","approvalYear":"1985","relationship":"same-target"},{"drugId":"bisoprolol","brandName":"bisoprolol","genericName":"bisoprolol","approvalYear":"1992","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"008203","UNII":"3W4327W76O","CHEBI":"CHEBI:134887","INN_ID":"1696","UMLSCUI":"C0055943","ChEMBL_ID":"CHEMBL1902627","KEGG_DRUG":"D01835","PUBCHEM_CID":"2810","SNOMEDCT_US":"96260001","SECONDARY_CAS_RN":"5588-22-7","MESH_SUPPLEMENTAL_RECORD_UI":"C004350"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":54,"therapeuticAreas":["Respiratory"],"biosimilarFilings":[],"recentPublications":[{"date":"2026 Mar 5","pmid":"41176858","title":"Deep learning-assisted surface-enhanced Raman spectroscopy detection of stimulants.","journal":"Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy"},{"date":"2024 Sep 1","pmid":"39142772","title":"Ultrasound probe enhanced enzymatic hydrolysis for rapid separation of β(2)-adrenergic agonists from animal urine and livestock wastewater: Applicability to biomonitoring investigation.","journal":"Analytica chimica acta"},{"date":"2024 Jul 15","pmid":"38917653","title":"Screening for promising multi-target bioactive components from Cortex Mori Radicis for the treatment of chronic cor pulmonale based on immobilized beta(1)-adrenergic receptor and beta(2)-adrenergic receptor chromatography.","journal":"Journal of chromatography. B, Analytical technologies in the biomedical and life sciences"},{"date":"2024 Aug 15","pmid":"38772203","title":"Determination of 13 potential anti-obesity agents in hair by dispersive liquid-liquid microextraction-assisted UHPLC-MS/MS.","journal":"Journal of pharmaceutical and biomedical analysis"},{"date":"2023 Dec","pmid":"38093540","title":"[Determination of 14 β-agonists in animal meat by ultra high performance liquid chromatography-tandem mass spectrometry].","journal":"Se pu = Chinese journal of chromatography"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Isoprofenamine, also known as clorprenaline, is a small molecule drug that targets the beta-2 adrenergic receptor. It is classified as a clorprenaline drug, but its current status and indications are unknown. As a beta-2 agonist, it works by stimulating the beta-2 receptors in the body, leading to bronchodilation and increased airway resistance. However, its commercial status, safety considerations, and pharmacokinetic properties are not well-documented. Further research is needed to fully understand its potential therapeutic applications and risks.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}