{"id":"clorotepine","rwe":[{"pmid":"7908055","year":"1994","title":"Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors.","finding":"","journal":"The Journal of pharmacology and experimental therapeutics","studyType":"Clinical Study"}],"tags":[{"label":"clorotepine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Histamine H1 receptor","category":"target"},{"label":"HRH1","category":"gene"},{"label":"DRD4","category":"gene"},{"label":"DRD3","category":"gene"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"_fixedAt":"2026-03-30T16:47:46.394001","allNames":"clotepin","offLabel":[],"synonyms":["clorotepine","(+/-)-Clothepin","octoclothepin","chlorothepin","clotepin","clothepin","octoclothepine"],"timeline":[],"approvals":[],"brandName":"Clotepin","ecosystem":[],"mechanism":{"target":"5-hydroxytryptamine receptor 6, D(4) dopamine receptor, 5-hydroxytryptamine receptor 2C","targets":[{"gene":"HRH1","source":"DrugCentral","target":"Histamine H1 receptor","protein":"Histamine H1 receptor","isPrimary":true,"activityType":"Ki","activityValue":9.72},{"gene":"DRD4","source":"DrugCentral","target":"D(4) dopamine receptor","protein":"D(4) dopamine receptor"},{"gene":"DRD3","source":"DrugCentral","target":"D(3) dopamine receptor","protein":"D(3) dopamine receptor"},{"gene":"HTR2C","source":"DrugCentral","target":"5-hydroxytryptamine receptor 2C","protein":"5-hydroxytryptamine receptor 2C"},{"gene":"DRD2","source":"DrugCentral","target":"D(2) dopamine receptor","protein":"D(2) dopamine receptor"},{"gene":"HTR6","source":"DrugCentral","target":"5-hydroxytryptamine receptor 6","protein":"5-hydroxytryptamine receptor 6"},{"gene":"TAAR1","source":"DrugCentral","target":"Trace amine-associated receptor 1","protein":"Trace amine-associated receptor 1"},{"gene":"KCNK9","source":"DrugCentral","target":"Potassium channel subfamily K member 9","protein":"Potassium channel subfamily K member 9"}],"modality":"Small Molecule","drugClass":"clorotepine","explanation":"Imagine your body has a system that helps you feel alert and awake, and another system that helps you relax and sleep. Histamine is a chemical that helps control these systems. Clorotepine blocks the histamine H1 receptor, which helps regulate these systems and can lead to a calming effect.","oneSentence":"Clorotepine works by blocking the histamine H1 receptor, which helps regulate various physiological processes.","technicalDetail":"Clorotepine acts as a competitive antagonist at the histamine H1 receptor, inhibiting the binding of histamine to the receptor and reducing the downstream effects of histamine signaling."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3912","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CLOROTEPINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:13:40.035018","biosimilars":[],"competitors":[{"drugName":"acepromazine","drugSlug":"acepromazine","fdaApproval":"","relationship":"same-target"},{"drugName":"acetophenazine","drugSlug":"acetophenazine","fdaApproval":"1961-04-05","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"amiodarone","drugSlug":"amiodarone","fdaApproval":"1985-12-24","patentExpiry":"Mar 13, 2029","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"amisulpride","drugSlug":"amisulpride","fdaApproval":"2020-02-26","patentExpiry":"Mar 10, 2031","patentStatus":"Patent 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It is also known by the synonyms Clorotepina, Clorotepine, and Clothepin.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}