{"id":"clorindione","rwe":[{"pmid":"21313725","year":"1965","title":"A Trial of Clorindione-A Long Acting Oral Anticoagulant.","finding":"","journal":"Postgraduate medical journal","studyType":"Clinical Study"}],"tags":[{"label":"clorindione","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"B01AA09","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"chlorindion","offLabel":[],"synonyms":["chlorphenylindandione","chlorphenindone","clorindione","chlophenadione","chlorathrombon","chlorindion","chlorindione","chlorphenadione","chlorphenindione"],"timeline":[],"approvals":[],"brandName":"Chlorindion","ecosystem":[],"mechanism":{"target":"Arachidonate 5-lipoxygenase","modality":"Small Molecule","drugClass":"clorindione","explanation":"Imagine your blood as a liquid that needs to turn into a solid to stop bleeding when you get hurt. Chlorindione helps this process by blocking an enzyme that's necessary for blood to clot. This can help people with bleeding disorders, but it also means they may be at risk of excessive bleeding if they take too much or have other health problems.","oneSentence":"Chlorindione works by blocking a specific enzyme that helps blood clotting.","technicalDetail":"Chlorindione inhibits the vitamin K-dependent gamma-glutamyl carboxylase enzyme, which is essential for the post-translational modification of clotting factors II, VII, IX, and X, leading to impaired blood coagulation."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3111","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CLORINDIONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:13:26.369290","biosimilars":[],"competitors":[{"drugName":"dicoumarol","drugSlug":"dicoumarol","fdaApproval":"1944-07-31","relationship":"same-class"},{"drugName":"phenindione","drugSlug":"phenindione","fdaApproval":"","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"warfarin","drugSlug":"warfarin","fdaApproval":"1954-06-08","genericCount":12,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"phenprocoumon","drugSlug":"phenprocoumon","fdaApproval":"1957-12-30","patentStatus":"Unknown","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"clorindione","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"dicoumarol","brandName":"dicoumarol","genericName":"dicoumarol","approvalYear":"1944","relationship":"same-class"},{"drugId":"phenindione","brandName":"phenindione","genericName":"phenindione","approvalYear":"","relationship":"same-class"},{"drugId":"warfarin","brandName":"warfarin","genericName":"warfarin","approvalYear":"1954","relationship":"same-class"},{"drugId":"phenprocoumon","brandName":"phenprocoumon","genericName":"phenprocoumon","approvalYear":"1957","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"002092","UNII":"541C7WS64R","CHEBI":"CHEBI:135057","INN_ID":"1534","RXNORM":"402527","UMLSCUI":"C0055939","ChEMBL_ID":"CHEMBL278519","KEGG_DRUG":"D07135","DRUGBANK_ID":"DB13275","PUBCHEM_CID":"70846","MESH_SUPPLEMENTAL_RECORD_UI":"C004665"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":1,"therapeuticAreas":["Hematology"],"atcClassification":{"source":"DrugCentral","atcCode":"B01AA09","allCodes":["B01AA09"]},"biosimilarFilings":[],"recentPublications":[{"date":"1965 Dec","pmid":"21313725","title":"A Trial of Clorindione-A Long Acting Oral Anticoagulant.","journal":"Postgraduate medical journal"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Chlorindion is a small molecule compound. It is also known by synonyms such as 2-(P-CHLOROPHENYL)-1,3-INDANDION, CLORINDIONA, CLORINDIONE, CLORINDIONE, G-25766, and NSC-758878.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}