{"id":"cloricromen","rwe":[{"pmid":"34352355","year":"2021","title":"The antithrombotic activity of natural and synthetic coumarins.","finding":"","journal":"Fitoterapia","studyType":"Clinical Study"},{"pmid":"7867874","year":"1994","title":"No effect of cloricromen on some coagulation parameters in patients with ischaemic cerebrovascular disease.","finding":"","journal":"The Journal of international medical research","studyType":"Clinical Study"}],"tags":[{"label":"cloricromen","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"B01AC02","category":"atc"},{"label":"Active","category":"status"},{"label":"Thromboembolic disorder","category":"indication"},{"label":"Hematologic Agents","category":"pharmacology"},{"label":"Platelet Aggregation Inhibitors","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"proendotel","offLabel":[],"synonyms":["cloricromen","cloricromene","cloricromen hydrochloride","proendotel","AD6"],"timeline":[],"approvals":[],"brandName":"Proendotel","ecosystem":[{"indication":"Thromboembolic disorder","otherDrugs":[{"name":"dicoumarol","slug":"dicoumarol","company":"Abbvie"},{"name":"phenprocoumon","slug":"phenprocoumon","company":"Organon Usa Inc"},{"name":"warfarin","slug":"warfarin","company":"Bristol Myers Squibb"}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"cloricromen","explanation":"Imagine your blood as a liquid with tiny particles called platelets that help it clot when you're injured. Cloricromen stops these platelets from sticking together as much, which can help prevent blood clots from forming and reduce the risk of thromboembolic disorders.","oneSentence":"Cloricromen works by inhibiting platelet aggregation, which is the process by which platelets clump together to form blood clots.","technicalDetail":"Cloricromen exerts its antiplatelet effects by inhibiting the P2Y12 receptor, a key component of the platelet activation pathway."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Cloricromen","title":"Cloricromen","extract":"Cloricromen is a platelet aggregation inhibitor. Coronary vasodilator."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/713","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CLORICROMEN","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Cloricromen","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T10:13:20.806332","biosimilars":[],"competitors":[{"drugName":"clopidogrel","drugSlug":"clopidogrel","fdaApproval":"1997-11-17","genericCount":23,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"ticlopidine","drugSlug":"ticlopidine","fdaApproval":"1991-10-31","genericCount":8,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"acetylsalicylic acid","drugSlug":"acetylsalicylic-acid","fdaApproval":"1950-04-12","relationship":"same-class"},{"drugName":"dipyridamole","drugSlug":"dipyridamole","fdaApproval":"1961-12-06","genericCount":17,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"epoprostenol","drugSlug":"epoprostenol","fdaApproval":"1995-09-20","patentExpiry":"Mar 15, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"iloprost","drugSlug":"iloprost","fdaApproval":"2004-12-29","patentExpiry":"Jul 18, 2044","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"abciximab","drugSlug":"abciximab","fdaApproval":"1993-12-16","relationship":"same-class"},{"drugName":"eptifibatide","drugSlug":"eptifibatide","fdaApproval":"1998-05-18","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"tirofiban","drugSlug":"tirofiban","fdaApproval":"1998-05-14","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"treprostinil","drugSlug":"treprostinil","fdaApproval":"2002-05-21","patentExpiry":"Sep 5, 2028","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"prasugrel","drugSlug":"prasugrel","fdaApproval":"2009-07-10","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"cilostazol","drugSlug":"cilostazol","fdaApproval":"1999-01-15","genericCount":12,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"ticagrelor","drugSlug":"ticagrelor","fdaApproval":"2011-07-20","patentExpiry":"Oct 17, 2030","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"cangrelor","drugSlug":"cangrelor","fdaApproval":"2015-06-22","patentExpiry":"Nov 10, 2030","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"vorapaxar","drugSlug":"vorapaxar","fdaApproval":"2014-05-08","patentExpiry":"Dec 23, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"selexipag","drugSlug":"selexipag","fdaApproval":"2015-12-21","patentExpiry":"Oct 31, 2026","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"cloricromen","indications":{"approved":[{"name":"Thromboembolic disorder","source":"DrugCentral","snomedId":371039008,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"clopidogrel","brandName":"clopidogrel","genericName":"clopidogrel","approvalYear":"1997","relationship":"same-class"},{"drugId":"ticlopidine","brandName":"ticlopidine","genericName":"ticlopidine","approvalYear":"1991","relationship":"same-class"},{"drugId":"acetylsalicylic-acid","brandName":"acetylsalicylic acid","genericName":"acetylsalicylic acid","approvalYear":"1950","relationship":"same-class"},{"drugId":"dipyridamole","brandName":"dipyridamole","genericName":"dipyridamole","approvalYear":"1961","relationship":"same-class"},{"drugId":"epoprostenol","brandName":"epoprostenol","genericName":"epoprostenol","approvalYear":"1995","relationship":"same-class"},{"drugId":"iloprost","brandName":"iloprost","genericName":"iloprost","approvalYear":"2004","relationship":"same-class"},{"drugId":"abciximab","brandName":"abciximab","genericName":"abciximab","approvalYear":"1993","relationship":"same-class"},{"drugId":"eptifibatide","brandName":"eptifibatide","genericName":"eptifibatide","approvalYear":"1998","relationship":"same-class"},{"drugId":"tirofiban","brandName":"tirofiban","genericName":"tirofiban","approvalYear":"1998","relationship":"same-class"},{"drugId":"treprostinil","brandName":"treprostinil","genericName":"treprostinil","approvalYear":"2002","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"B9454PE93C","CHEBI":"CHEBI:135628","INN_ID":"5623","UMLSCUI":"C0050066","ChEMBL_ID":"CHEMBL255066","KEGG_DRUG":"D07139","DRUGBANK_ID":"DB13367","PUBCHEM_CID":"68876","SECONDARY_CAS_RN":"74697-28-2","MESH_SUPPLEMENTAL_RECORD_UI":"C025945"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":2,"therapeuticAreas":["Cardiovascular"],"atcClassification":{"source":"DrugCentral","atcCode":"B01AC02","allCodes":["B01AC02"]},"biosimilarFilings":[],"recentPublications":[{"date":"2021 Oct","pmid":"34352355","title":"The antithrombotic activity of natural and synthetic coumarins.","journal":"Fitoterapia"},{"date":"1994 Sep-Oct","pmid":"7867874","title":"No effect of cloricromen on some coagulation parameters in patients with ischaemic cerebrovascular disease.","journal":"The Journal of international medical research"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Proendotel, also known as Cloricromen, is a small molecule drug in the cloricromen class. It is used to treat thromboembolic disorders, although its exact target is unknown. The commercial status of Proendotel is unclear, and it is not known whether it is patented or available as a generic. Further information on its pharmacokinetics, such as half-life and bioavailability, is also lacking. As a result, key safety considerations and potential side effects are not well established.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}