{"id":"clorhexidine-gel","safety":{"commonSideEffects":[{"rate":null,"effect":"Tooth staining"},{"rate":null,"effect":"Taste alteration"},{"rate":null,"effect":"Oral irritation or ulceration"},{"rate":null,"effect":"Allergic contact dermatitis"}]},"_chembl":{"chemblId":"CHEMBL2109015","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Chlorhexidine is a cationic bisbiguanide that binds to negatively charged bacterial cell membranes, causing leakage of cellular contents and cell death. It is effective against a wide range of gram-positive and gram-negative bacteria, as well as some fungi and viruses. The gel formulation allows for topical application and prolonged contact with affected tissues.","oneSentence":"Chlorhexidine gel works as a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, providing antiseptic and disinfectant effects.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:43:33.101Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Oral antisepsis and plaque control"},{"name":"Wound disinfection and antisepsis"},{"name":"Topical antimicrobial treatment"}]},"trialDetails":[{"nctId":"NCT04000854","phase":"NA","title":"Regenerative Treatment of Traumatized Immature Permanent Incisors With Pulp Necrosis","status":"UNKNOWN","sponsor":"Karolinska Institutet","startDate":"2019-02-19","conditions":"Regenerative Endodontics in Traumatized Immature Teeth","enrollment":180},{"nctId":"NCT04584840","phase":"NA","title":"Initial Management of MRONJ Stages I and II, a Clinical Trial With Detection of Salivary Biomarkers","status":"UNKNOWN","sponsor":"Fundació d'investigació Sanitària de les Illes Balears","startDate":"2020-11-01","conditions":"Osteonecrosis of the Jaw, Bisphosphonate Induced, Osteonecrosis of the Jaw, Bisphosphonate Related","enrollment":50},{"nctId":"NCT03633292","phase":"PHASE4","title":"Aloe Vera and Chlorhexidine Against Traumatic Oral Ulcers","status":"COMPLETED","sponsor":"University of Santiago de Compostela","startDate":"2015-01","conditions":"Oral Ulcer","enrollment":140},{"nctId":"NCT03142828","phase":"PHASE4","title":"Implant Healing Abutment and Chlorhexidine","status":"COMPLETED","sponsor":"Universidad de Murcia","startDate":"2017-04-15","conditions":"Periimplantitis","enrollment":100},{"nctId":"NCT03188289","phase":"PHASE4","title":"Microbial Growth in the Suture Thread, After Application of Different Antiseptic Gels in Mandibular Third Molars Extraction","status":"COMPLETED","sponsor":"University of Santiago de Compostela","startDate":"2014-01-20","conditions":"Wisdom Teeth, Oral Surgery, Third Molar Surgery","enrollment":21},{"nctId":"NCT00681564","phase":"PHASE3","title":"Periodontal Infection and Endothelial Dysfunction","status":"COMPLETED","sponsor":"Universidad del Valle, Colombia","startDate":"2008-05","conditions":"Periodontitis","enrollment":102}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Bexident encías"],"phase":"marketed","status":"active","brandName":"Clorhexidine gel","genericName":"Clorhexidine gel","companyName":"University of Santiago de Compostela","companyId":"university-of-santiago-de-compostela","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Chlorhexidine gel works as a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, providing antiseptic and disinfectant effects. Used for Oral antisepsis and plaque control, Wound disinfection and antisepsis, Topical antimicrobial treatment.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}