{"id":"clorexolone","rwe":[{"pmid":"6105713","year":"1980","title":"The antihypertensive effect of guanfacine compared with methyldopa.","finding":"","journal":"South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde","studyType":"Clinical Study"},{"pmid":"788747","year":"1976","title":"Lithium and the antidiuretic hormone.","finding":"","journal":"British journal of clinical pharmacology","studyType":"Clinical Study"},{"pmid":"4567002","year":"1973","title":"A controlled study of clopamide, clorexolone, and hydrochlorothiazide in diabetics.","finding":"","journal":"Metabolism: clinical and experimental","studyType":"Clinical Study"},{"pmid":"4887299","year":"1969","title":"Comparison of clorexolone, a new diuretic, with hydrochlorothiazide.","finding":"","journal":"Clinical pharmacology and therapeutics","studyType":"Clinical Study"},{"pmid":"5715956","year":"1968","title":"[Biochemico-clinical studies on the activity of a new oral diuretic (clorexolone) in persons of advanced age].","finding":"","journal":"Giornale di gerontologia","studyType":"Clinical Study"}],"tags":[{"label":"clorexolone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"C03BA12","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"clorexolon","offLabel":[],"synonyms":["clorexolone","chlorexolone","clorexolon"],"timeline":[],"approvals":[],"brandName":"Clorexolon","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"clorexolone","explanation":"Imagine your body's natural response to injury or infection is like a fire alarm that goes off to alert the immune system. Clorexolone is like a fire extinguisher that helps to reduce the noise and activity of the alarm, which can help to reduce pain and inflammation. This can be beneficial for people with conditions like arthritis or other inflammatory diseases.","oneSentence":"Clorexolone is thought to work by inhibiting the activity of certain enzymes involved in inflammation and pain.","technicalDetail":"Clorexolone is a non-steroidal anti-inflammatory agent that likely exerts its effects by inhibiting the activity of enzymes such as COX-1 and COX-2, which are involved in the production of prostaglandins and other inflammatory mediators."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/712","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CLOREXOLONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:13:29.047332","biosimilars":[],"competitors":[{"drugName":"quinethazone","drugSlug":"quinethazone","fdaApproval":"1963-04-10","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"chlortalidone","drugSlug":"chlortalidone","fdaApproval":"1960-04-07","relationship":"same-class"},{"drugName":"metolazone","drugSlug":"metolazone","fdaApproval":"1973-11-27","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"indapamide","drugSlug":"indapamide","fdaApproval":"1983-07-06","genericCount":7,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"clorexolone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"quinethazone","brandName":"quinethazone","genericName":"quinethazone","approvalYear":"1963","relationship":"same-class"},{"drugId":"chlortalidone","brandName":"chlortalidone","genericName":"chlortalidone","approvalYear":"1960","relationship":"same-class"},{"drugId":"metolazone","brandName":"metolazone","genericName":"metolazone","approvalYear":"1973","relationship":"same-class"},{"drugId":"indapamide","brandName":"indapamide","genericName":"indapamide","approvalYear":"1983","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"Q2PLT3FS05","CHEBI":"CHEBI:31421","INN_ID":"1795","UMLSCUI":"C0055938","ChEMBL_ID":"CHEMBL2106167","KEGG_DRUG":"D01436","DRUGBANK_ID":"DB13617","PUBCHEM_CID":"16473","MESH_SUPPLEMENTAL_RECORD_UI":"C017137"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":14,"therapeuticAreas":["Pain"],"atcClassification":{"source":"DrugCentral","atcCode":"C03BA12","allCodes":["C03BA12","C03BA82"]},"biosimilarFilings":[],"recentPublications":[{"date":"1980 Mar 15","pmid":"6105713","title":"The antihypertensive effect of guanfacine compared with methyldopa.","journal":"South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde"},{"date":"1976 Apr","pmid":"788747","title":"Lithium and the antidiuretic hormone.","journal":"British journal of clinical pharmacology"},{"date":"1973 Feb","pmid":"4567002","title":"A controlled study of clopamide, clorexolone, and hydrochlorothiazide in diabetics.","journal":"Metabolism: clinical and experimental"},{"date":"1969 Mar-Apr","pmid":"4887299","title":"Comparison of clorexolone, a new diuretic, with hydrochlorothiazide.","journal":"Clinical pharmacology and therapeutics"},{"date":"1968 Mar","pmid":"5715956","title":"[Biochemico-clinical studies on the activity of a new oral diuretic (clorexolone) in persons of advanced age].","journal":"Giornale di gerontologia"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Clorexolone is a small molecule drug in the clorexolone class, but specific details about its development, approval status, and commercial status are not available. As a result, there is limited information about its target, approved indications, half-life, bioavailability, and generic manufacturers. Further research is needed to understand the pharmacology and clinical applications of clorexolone. The current owner of clorexolone is not specified, and its original developer is also unknown. Overall, clorexolone remains a relatively obscure compound with unclear clinical utility.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}