{"id":"cloprednol","rwe":[],"tags":[{"label":"cloprednol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"H02AB14","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"cloradryn","offLabel":[],"synonyms":["cloprednol","cloprednole","cloradryn"],"timeline":[],"approvals":[],"brandName":"Cloradryn","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"cloprednol","explanation":"Think of glucocorticoid receptors like special locks in your cells. Cloradryn is a key that fits into these locks, which helps to regulate various bodily functions, such as inflammation and immune response. By binding to these receptors, Cloradryn can influence how your cells behave and respond to different stimuli.","oneSentence":"Cloradryn works by interacting with the body's glucocorticoid receptors.","technicalDetail":"Cloradryn is a synthetic glucocorticoid agonist that binds to the glucocorticoid receptor (GR), a transcription factor that regulates gene expression in response to glucocorticoid hormones. Upon binding, Cloradryn activates the GR, leading to changes in gene expression and protein synthesis that modulate inflammatory and immune responses."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/709","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CLOPREDNOL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:13:17.462570","biosimilars":[],"competitors":[{"drugName":"betamethasone","drugSlug":"betamethasone","fdaApproval":"1961-04-17","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"dexamethasone","drugSlug":"dexamethasone","fdaApproval":"1958-10-30","patentExpiry":"Oct 7, 2036","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"methylprednisolone","drugSlug":"methylprednisolone","fdaApproval":"1957-10-24","genericCount":14,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"paramethasone acetate","drugSlug":"paramethasone-acetate","fdaApproval":"","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"prednisolone","drugSlug":"prednisolone","fdaApproval":"1955-06-21","genericCount":42,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"prednisone","drugSlug":"prednisone","fdaApproval":"1955-02-21","patentExpiry":"Jan 7, 2028","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"triamcinolone","drugSlug":"triamcinolone","fdaApproval":"1957-12-03","genericCount":9,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"hydrocortisone","drugSlug":"hydrocortisone","fdaApproval":"1952-08-05","patentExpiry":"Nov 19, 2032","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"rimexolone","drugSlug":"rimexolone","fdaApproval":"1994-12-30","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"deflazacort","drugSlug":"deflazacort","fdaApproval":"2017-02-09","genericCount":8,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"meprednisone","drugSlug":"meprednisone","fdaApproval":"1978-01-26","patentStatus":"Unknown","relationship":"same-class"}],"genericName":"cloprednol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"betamethasone","brandName":"betamethasone","genericName":"betamethasone","approvalYear":"1961","relationship":"same-class"},{"drugId":"dexamethasone","brandName":"dexamethasone","genericName":"dexamethasone","approvalYear":"1958","relationship":"same-class"},{"drugId":"methylprednisolone","brandName":"methylprednisolone","genericName":"methylprednisolone","approvalYear":"1957","relationship":"same-class"},{"drugId":"paramethasone-acetate","brandName":"paramethasone acetate","genericName":"paramethasone acetate","approvalYear":"","relationship":"same-class"},{"drugId":"prednisolone","brandName":"prednisolone","genericName":"prednisolone","approvalYear":"1955","relationship":"same-class"},{"drugId":"prednisone","brandName":"prednisone","genericName":"prednisone","approvalYear":"1955","relationship":"same-class"},{"drugId":"triamcinolone","brandName":"triamcinolone","genericName":"triamcinolone","approvalYear":"1957","relationship":"same-class"},{"drugId":"hydrocortisone","brandName":"hydrocortisone","genericName":"hydrocortisone","approvalYear":"1952","relationship":"same-class"},{"drugId":"rimexolone","brandName":"rimexolone","genericName":"rimexolone","approvalYear":"1994","relationship":"same-class"},{"drugId":"deflazacort","brandName":"deflazacort","genericName":"deflazacort","approvalYear":"2017","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"006002","UNII":"SYP56O3GJG","CHEBI":"CHEBI:135619","INN_ID":"3566","RXNORM":"21285","UMLSCUI":"C0055936","ChEMBL_ID":"CHEMBL1697832","KEGG_DRUG":"D03561","DRUGBANK_ID":"DB13843","PUBCHEM_CID":"5284535","MESH_SUPPLEMENTAL_RECORD_UI":"C011731"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":17,"therapeuticAreas":["Immunology"],"atcClassification":{"source":"DrugCentral","atcCode":"H02AB14","allCodes":["H02AB14"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cloradryn, also known as Cloprednol, is a small molecule drug in the cloprednol class. Its exact target and mechanism of action are unknown, but it is believed to work by interacting with the body's glucocorticoid receptors. Cloradryn's commercial status and approved indications are unclear, and it is not known whether it is patented or available as a generic medication. Further research is needed to fully understand its properties and potential uses. As a result, key safety considerations and pharmacokinetic parameters, such as half-life and bioavailability, are also unknown.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}