{"id":"clopidogrel-sr25990","safety":{"commonSideEffects":[{"rate":"3-5","effect":"Bleeding"},{"rate":"5-10","effect":"Dyspepsia"},{"rate":"2-4","effect":"Diarrhea"},{"rate":"1-3","effect":"Rash"},{"rate":"<0.1","effect":"Thrombotic thrombocytopenic purpura (TTP)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Clopidogrel is a prodrug that requires hepatic metabolism to form its active metabolite, which then binds irreversibly to the P2Y12 receptor on platelet surfaces. This prevents ADP-mediated platelet activation and aggregation, reducing thrombotic events. The drug is used to prevent blood clots in patients at risk of cardiovascular events.","oneSentence":"Clopidogrel is a thienopyridine antiplatelet agent that irreversibly inhibits ADP-induced platelet aggregation by blocking the P2Y12 adenosine diphosphate receptor on platelets.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:06:26.127Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute coronary syndrome (unstable angina, NSTEMI, STEMI)"},{"name":"Secondary prevention of atherothrombotic events in patients with established cardiovascular disease"},{"name":"Stroke prevention in patients with recent ischemic stroke or transient ischemic attack"}]},"trialDetails":[{"nctId":"NCT00396877","phase":"PHASE3","title":"Efficacy And Safety Of Clopidogrel In Neonates /Infants With Systemic To Pulmonary Artery Shunt Palliation","status":"COMPLETED","sponsor":"Sanofi","startDate":"2006-11","conditions":"Heart Defects, Congenital","enrollment":906},{"nctId":"NCT00862420","phase":"PHASE3","title":"Safety Evaluation of Clopidogrel Sulfate in Patients With Peripheral Arterial Disease","status":"COMPLETED","sponsor":"Sanofi","startDate":"2009-02","conditions":"Peripheral Arterial Disease (PAD)","enrollment":431},{"nctId":"NCT00050817","phase":"PHASE3","title":"Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance (CHARISMA)","status":"COMPLETED","sponsor":"Sanofi","startDate":"2002-10","conditions":"Arteriosclerosis","enrollment":15603},{"nctId":"NCT01129375","phase":"PHASE1","title":"Interaction Study of Clopidogrel 300/75 mg Given Alone or Concomitantly With Omeprazole 80 mg in Healthy Subjects","status":"COMPLETED","sponsor":"Sanofi","startDate":"2009-02","conditions":"Healthy","enrollment":72},{"nctId":"NCT01129427","phase":"PHASE1","title":"Interaction Study of Clopidogrel 300/75 mg Given Alone or Concomitantly With Pantoprazole 80 mg in Healthy Subjects","status":"COMPLETED","sponsor":"Sanofi","startDate":"2009-08","conditions":"Healthy","enrollment":66},{"nctId":"NCT01129414","phase":"PHASE1","title":"Interaction Study of Clopidogrel 600/150 mg Given Alone or Concomitantly With Omeprazole 80 mg in Healthy Subjects","status":"COMPLETED","sponsor":"Sanofi","startDate":"2009-06","conditions":"Healthy","enrollment":72},{"nctId":"NCT01123824","phase":"PHASE1","title":"Pharmacodynamic and Pharmacokinetic Study of 2 Different Dose Regimen of Clopidogrel in CYP2C19 Genotyped Healthy Subjects","status":"COMPLETED","sponsor":"Sanofi","startDate":"2009-04","conditions":"Healthy","enrollment":40},{"nctId":"NCT01129388","phase":"PHASE1","title":"Interaction Study of Clopidogrel 300/75 mg Given Alone or With Omeprazole 80 mg 12 Hours Apart in Healthy Subjects","status":"COMPLETED","sponsor":"Sanofi","startDate":"2009-03","conditions":"Healthy","enrollment":72},{"nctId":"NCT00833703","phase":"PHASE3","title":"Long Term Safety of Clopidogrel in Neonates/Infants With Systemic to Pulmonary Artery Shunt Palliation","status":"COMPLETED","sponsor":"Sanofi","startDate":"2009-01","conditions":"Heart Defects, Congenital","enrollment":49},{"nctId":"NCT00821834","phase":"PHASE3","title":"Safety Evaluation of Clopidogrel Sulfate in Patients With Stable Angina/Old Myocardial Infarction to Whom Percutaneous Coronary Intervention is Being Planned","status":"COMPLETED","sponsor":"Sanofi","startDate":"2008-12","conditions":"Stable Angina, Myocardial Infarction","enrollment":1003},{"nctId":"NCT00335452","phase":"PHASE3","title":"Clopidogrel Optimal Loading Dose Usage to Reduce Recurrent EveNTs/Optimal Antiplatelet Strategy for InterventionS","status":"COMPLETED","sponsor":"Sanofi","startDate":"2006-06","conditions":"Acute Coronary Disease, Angina Unstable","enrollment":25086},{"nctId":"NCT01129063","phase":"PHASE1","title":"Pharmacokinetic Study of Single Doses of Clopidogrel, 75 mg and 300 mg, in Healthy Subjects","status":"COMPLETED","sponsor":"Sanofi","startDate":"2009-03","conditions":"Healthy","enrollment":32},{"nctId":"NCT00714961","phase":"PHASE3","title":"Clopidogrel as Adjunctive Reperfusion Therapy - Thrombolysis in Myocardial Infarction","status":"COMPLETED","sponsor":"Sanofi","startDate":"2003-02","conditions":"Acute Coronary Syndromes","enrollment":3491},{"nctId":"NCT00115375","phase":"PHASE2","title":"Platelet Aggregation Inhibition in Children on Clopidogrel (PICOLO)","status":"COMPLETED","sponsor":"Sanofi","startDate":"2004-01","conditions":"Congenital Heart Defects, Blood Platelet Disorders","enrollment":92}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Plavix"],"phase":"phase_3","status":"active","brandName":"Clopidogrel (SR25990)","genericName":"Clopidogrel (SR25990)","companyName":"Sanofi","companyId":"sanofi","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Clopidogrel is a small molecule medication used to treat certain conditions. It has been studied in clinical trials for long-term safety in neonates and infants with systemic to pulmonary artery shunt palliation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}