{"id":"clopidogrel-loading","safety":{"commonSideEffects":[{"rate":"3-5","effect":"Bleeding"},{"rate":"5-10","effect":"Dyspepsia"},{"rate":"2-5","effect":"Diarrhea"},{"rate":"1-3","effect":"Rash"},{"rate":"<0.1","effect":"Thrombotic thrombocytopenic purpura (TTP)"}]},"_chembl":{"chemblId":"CHEMBL1771","moleculeType":"Small molecule","molecularWeight":"321.83"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Clopidogrel requires hepatic metabolism to its active form, which then binds irreversibly to the P2Y12 receptor on platelet surfaces. This prevents ADP-induced platelet activation and aggregation, reducing thrombotic events. A loading dose is used to rapidly achieve platelet inhibition in acute clinical settings.","oneSentence":"Clopidogrel is a prodrug that irreversibly inhibits platelet aggregation by blocking the P2Y12 adenosine diphosphate receptor.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:30:18.701Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute coronary syndrome (unstable angina, NSTEMI, STEMI)"},{"name":"Secondary prevention of atherothrombotic events in patients with recent myocardial infarction, stroke, or peripheral arterial disease"}]},"trialDetails":[{"nctId":"NCT06650488","phase":"PHASE4","title":"Clopidogrel vs. Aspirin for Cardiovascular Risk Reduction in Patients With S. Aureus Bacteremia","status":"RECRUITING","sponsor":"Todd C. Lee MD MPH FIDSA","startDate":"2026-01-15","conditions":"Staphylococcus Aureus Endocarditis, Staphylococcus Aureus Septicemia, Staphylococcus Aureus Bloodstream Infection","enrollment":300},{"nctId":"NCT07468448","phase":"PHASE3","title":"Combination Antithrombotic Treatment for Prevention of Recurrent Ischemic Stroke in IntraCranial Atherosclerotic diseaSe (CATIS- ICAS)","status":"NOT_YET_RECRUITING","sponsor":"Population Health Research Institute","startDate":"2026-05-30","conditions":"Ischemic Stroke, Intracranial Atherosclerosis","enrollment":1172},{"nctId":"NCT05047172","phase":"PHASE3","title":"Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Florida","startDate":"2022-08-02","conditions":"Intracranial Arteriosclerosis, Stroke","enrollment":1683},{"nctId":"NCT06037889","phase":"PHASE3","title":"Efficacy and Safety of Tirofiban for Patients With BAD (BRANT)","status":"COMPLETED","sponsor":"Peking Union Medical College Hospital","startDate":"2023-11-09","conditions":"Branch Atheromatous Disease","enrollment":516},{"nctId":"NCT04809818","phase":"PHASE1","title":"A Study to Evaluate Safety and PK of Multiple Doses of LT3001 Drug Product and Drug-drug Interaction in Healthy Subjects","status":"COMPLETED","sponsor":"Lumosa Therapeutics Co., Ltd.","startDate":"2021-03-21","conditions":"Acute Ischemic Stroke","enrollment":65},{"nctId":"NCT05225961","phase":"PHASE4","title":"ATILA Project: Aspirin Versus Tirofiban in Endovascular Treatment for Patients With Acute Ischemic Stroke Due to Tandem Lesion","status":"ACTIVE_NOT_RECRUITING","sponsor":"Fundación Pública Andaluza para la gestión de la Investigación en Sevilla","startDate":"2022-05-01","conditions":"Acute Ischemic Stroke","enrollment":240},{"nctId":"NCT04014803","phase":"PHASE4","title":"Aspirin and a PoTent P2Y12 Inhibitor Versus Aspirin and Clopidogrel in Patients Undergoing PCI for Complex Lesion","status":"RECRUITING","sponsor":"Samsung Medical Center","startDate":"2020-01-13","conditions":"Coronary Artery Disease","enrollment":3500},{"nctId":"NCT06228456","phase":"PHASE4","title":"Effects of Low-dose Ticagrelor vs. Clopidogrel in Stable Patients Undergoing Elective Percutaneous Coronary Intervention","status":"RECRUITING","sponsor":"University of Florida","startDate":"2024-04-01","conditions":"Coronary Artery Disease","enrollment":50},{"nctId":"NCT05785897","phase":"NA","title":"STEMI Treated With a Polymer-free Sirolimus-coated Stent and P2Y12 Inhibitor-based SAPT Versus Conventional DAPT","status":"RECRUITING","sponsor":"IGLESIAS Juan Fernando","startDate":"2025-11-01","conditions":"ST Elevation Myocardial Infarction","enrollment":350},{"nctId":"NCT06853535","phase":"PHASE3","title":"Precision Antiplatelet Therapy Guided by Platelet Aggregation Function in Patients With Acute Ischemic STROKE","status":"RECRUITING","sponsor":"Sichuan Provincial People's Hospital","startDate":"2025-05-23","conditions":"Acute Ischemic Stroke, Clopidogrel Resistance","enrollment":5138},{"nctId":"NCT07275749","phase":"PHASE3","title":"Acetyl-leucine in Post-stroke Ataxia","status":"RECRUITING","sponsor":"Kafrelsheikh University","startDate":"2025-12-01","conditions":"Ischemic Stroke","enrollment":200},{"nctId":"NCT06591377","phase":"PHASE3","title":"Combining Aspirin With Ticagrelor or Cilostazol in Large-vessel Minor Stroke or TIA","status":"RECRUITING","sponsor":"Kafrelsheikh University","startDate":"2024-08-10","conditions":"Ischemic Stroke","enrollment":900},{"nctId":"NCT06638151","phase":"PHASE2","title":"Clopidogrel Plus Aspirin in Acute Ischemic Stroke Following Thrombectomy and/or Intravenous Thrombolysis (CoPrime)","status":"RECRUITING","sponsor":"University of Alberta","startDate":"2025-09-02","conditions":"Acute Ischemic Stroke","enrollment":200},{"nctId":"NCT06358313","phase":"PHASE3","title":"Concomitant Use of Clopidogrel With Atorvastatin or Rosuvastatin in Patients With Moderate and Moderate-to-severe Stroke","status":"RECRUITING","sponsor":"Kafrelsheikh University","startDate":"2024-04-10","conditions":"Ischemic Stroke","enrollment":600},{"nctId":"NCT06591338","phase":"PHASE3","title":"Combining Aspirin With Ticagrelor or Clopidogrel in Large-vessel Minor Stroke or TIA","status":"RECRUITING","sponsor":"Kafrelsheikh University","startDate":"2024-09-01","conditions":"Ischemic Stroke","enrollment":900},{"nctId":"NCT06360120","phase":"PHASE3","title":"Combining Use of Clopidogrel With Atorvastatin or Rosuvastatin in Patients With Large-vessel Ischemic Stroke","status":"RECRUITING","sponsor":"Kafrelsheikh University","startDate":"2024-04-10","conditions":"Ischemic Stroke","enrollment":600},{"nctId":"NCT07095790","phase":"PHASE4","title":"Tirofiban With Sequential Dual Antiplatelet Therapy in Mild Stroke","status":"RECRUITING","sponsor":"Second Affiliated Hospital of Soochow University","startDate":"2025-08-30","conditions":"Mild Stroke","enrollment":580},{"nctId":"NCT04483583","phase":"PHASE4","title":"Tailoring P2Y12 Inhibiting Therapy in Patients Requiring Oral Anticoagulation After PCI","status":"COMPLETED","sponsor":"University of Florida","startDate":"2020-12-08","conditions":"Coronary Artery Disease","enrollment":81},{"nctId":"NCT06318481","phase":"PHASE3","title":"TADCLOT- a Double Blind Randomized Controlled Trial","status":"COMPLETED","sponsor":"National Institute of Cardiovascular Diseases, Pakistan","startDate":"2024-02-19","conditions":"Stent Thrombosis, Myocardial Infarction, Acute","enrollment":2200},{"nctId":"NCT03357874","phase":"PHASE3","title":"TicagRelor Or Clopidogrel in Severe and Terminal Chronic Kidney Disease Patients Undergoing PERcutaneous Coronary Intervention for an Acute Coronary Syndrome.","status":"COMPLETED","sponsor":"Assistance Publique Hopitaux De Marseille","startDate":"2018-10-28","conditions":"Acute Coronary Syndrome","enrollment":259},{"nctId":"NCT01777503","phase":"PHASE4","title":"The Elderly ACS II Trial","status":"COMPLETED","sponsor":"Azienda USL Reggio Emilia - IRCCS","startDate":"2012-11","conditions":"Acute Coronary Syndrome, Coronary Arteriosclerosis, Myocardial Ischemia","enrollment":1457},{"nctId":"NCT03465644","phase":"PHASE4","title":"TAILored Versus COnventional AntithRombotic StratEgy IntenDed for Complex HIgh-Risk PCI","status":"COMPLETED","sponsor":"Duk-Woo Park, MD","startDate":"2019-02-12","conditions":"Coronary Stenoses","enrollment":2018},{"nctId":"NCT06943586","phase":"NA","title":"Pharmacogenomics in Stroke: Feasibility of CYP2C19 Testing","status":"RECRUITING","sponsor":"University of Alabama at Birmingham","startDate":"2025-04-09","conditions":"Stroke, Transient Ischemic Attack (TIA)","enrollment":200},{"nctId":"NCT04824911","phase":"PHASE2","title":"Statin and Dual Antiplatelet Therapy to Prevent Early Neurological Deterioration in Branch Atheromatous Disease","status":"COMPLETED","sponsor":"Chang Gung Memorial Hospital","startDate":"2021-03-23","conditions":"Acute Stroke, Dual Antiplatelet Therapy, Statin","enrollment":376},{"nctId":"NCT06089577","phase":"PHASE4","title":"Effects of Cangrelor on MIcRovAscular Disfunction During Elective Percutaneous CORonary Intervention","status":"RECRUITING","sponsor":"Federico II University","startDate":"2023-11-01","conditions":"Coronary Artery Disease","enrollment":80},{"nctId":"NCT06601127","phase":"PHASE2","title":"Study of Tiprogrel in the Treatment of High-risk Patients with Acute Ischemic Cerebrovascular Events (THRIVE).","status":"RECRUITING","sponsor":"Tianjin Institute of Pharmaceutical Research Co., Ltd","startDate":"2025-02-21","conditions":"Ischemic Stroke","enrollment":600},{"nctId":"NCT06759272","phase":"PHASE4","title":"Impact of CYP2C19 Genotype-guided Approach in Antiplatelet Therapy on Platelet Reactivity Index Among Coronary Artery Disease (CAD) Patients","status":"NOT_YET_RECRUITING","sponsor":"Nur Hafizah Annezah binti Utuh","startDate":"2025-02","conditions":"Coronary Arterial Disease (CAD), ACS (Acute Coronary Syndrome), SCAD","enrollment":120},{"nctId":"NCT06584812","phase":"PHASE1","title":"Study to Assess Pharmacokinetics, Pharmacodynamics and Safety of Tiprogrel in Healthy Subjects","status":"COMPLETED","sponsor":"Tianjin Institute of Pharmaceutical Research Co., Ltd","startDate":"2024-09-09","conditions":"Acute Coronary Syndrome, Ischemic Stroke","enrollment":14},{"nctId":"NCT03606642","phase":"PHASE2","title":"SYNergy Stent® System Implantation With Mandatory Intra-VascularUltra-Sound Guidance and Dual Anti-Platelet Therapy","status":"TERMINATED","sponsor":"HonorHealth Research Institute","startDate":"2018-11-19","conditions":"Coronary Artery Disease, Atherosclerosis, Stent Placement","enrollment":50},{"nctId":"NCT05926271","phase":"PHASE2","title":"POPular GUILTY PILOT: Genotype-guided Clopidogrel Monotherapy","status":"RECRUITING","sponsor":"St. Antonius Hospital","startDate":"2023-07-15","conditions":"Acute Coronary Syndrome, CYP2C19 Polymorphism","enrollment":200},{"nctId":"NCT06587347","phase":"PHASE2, PHASE3","title":"Tirofiban for the Prevention of Early Neurological Deterioration After Intravenous Thrombolysis in Acute Ischemic Stroke","status":"NOT_YET_RECRUITING","sponsor":"Capital Medical University","startDate":"2024-11-20","conditions":"Acute Stroke, Ischemic Stroke, Acute, Cerebral Infarction","enrollment":302},{"nctId":"NCT02777580","phase":"PHASE4","title":"STrategic Reperfusion in Elderly Patients Early After Myocardial Infarction","status":"COMPLETED","sponsor":"KU Leuven","startDate":"2017-08-01","conditions":"Myocardial Infarction","enrollment":609},{"nctId":"NCT06577519","phase":"PHASE3","title":"Efficacy and Safety Study of Vicagrel in Patients With Acute Coronary Syndrome (ACS) Undergoing Percutaneous Coronary Intervention (PCI)","status":"RECRUITING","sponsor":"Jiangsu vcare pharmaceutical technology co., LTD","startDate":"2024-09-06","conditions":"Acute Coronary Syndrome (ACS) Undergoing Percutaneous Coronary Intervention (PCI)","enrollment":1000},{"nctId":"NCT06591390","phase":"PHASE3","title":"Combining Aspirin With Ticagrelor or Cilostazol in Minor Stroke or TIA","status":"RECRUITING","sponsor":"Kafrelsheikh University","startDate":"2022-02-09","conditions":"Ischemic Stroke","enrollment":900},{"nctId":"NCT06591299","phase":"PHASE3","title":"Combining Aspirin With Cilostazol or Clopidogrel in Minor Stroke or TIA","status":"RECRUITING","sponsor":"Kafrelsheikh University","startDate":"2022-04-15","conditions":"Ischemic Stroke","enrollment":870},{"nctId":"NCT06591351","phase":"PHASE3","title":"Combining Aspirin With Cilostazol or Clopidogrel in Large-vessel Minor Stroke or TIA","status":"RECRUITING","sponsor":"Kafrelsheikh University","startDate":"2022-05-01","conditions":"Ischemic Stroke","enrollment":870},{"nctId":"NCT06242132","phase":"PHASE3","title":"Clopidogrel Versus Cilostazol in Ischemic Stroke","status":"COMPLETED","sponsor":"Kafrelsheikh University","startDate":"2022-06-01","conditions":"Ischemic Stroke","enrollment":870},{"nctId":"NCT06591312","phase":"PHASE3","title":"Combining Aspirin With Ticagrelor or Clopidogrel in Minor Stroke or TIA","status":"RECRUITING","sponsor":"Kafrelsheikh University","startDate":"2022-05-01","conditions":"Ischemic Stroke","enrollment":900},{"nctId":"NCT05117866","phase":"NA","title":"Acetyl Salicylic Elimination Trial JAPAN: The ASET JAPAN Pilot Study","status":"ACTIVE_NOT_RECRUITING","sponsor":"Meditrix Corp","startDate":"2020-09-15","conditions":"Chronic Coronary Syndrome, Non ST Segment Elevation Acute Coronary Syndrome","enrollment":307},{"nctId":"NCT06242145","phase":"PHASE3","title":"Clopidogrel Versus Cilostazol in Large-vessel Ischemic Stroke","status":"COMPLETED","sponsor":"Kafrelsheikh University","startDate":"2023-01-01","conditions":"Ischemic Stroke","enrollment":580},{"nctId":"NCT06561867","phase":"PHASE3","title":"Ticagrelor Versus Cilostazol in Ischemic Stroke","status":"RECRUITING","sponsor":"Kafrelsheikh University","startDate":"2024-08-30","conditions":"Ischemic Stroke","enrollment":900},{"nctId":"NCT06202755","phase":"PHASE3","title":"Ticagrelor Versus Cilostazol in Large-vessel Ischemic Stroke","status":"RECRUITING","sponsor":"Kafrelsheikh University","startDate":"2024-03-30","conditions":"Ischemic Stroke","enrollment":580},{"nctId":"NCT05122780","phase":"PHASE4","title":"Prognostic Value of Precision Medicine in Patients With MINOCA (PROMISE Trial).","status":"ACTIVE_NOT_RECRUITING","sponsor":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","startDate":"2021-07-01","conditions":"Myocardial Infarction With Non-Obstructive Coronary Arteries","enrollment":120},{"nctId":"NCT02735707","phase":"PHASE3","title":"Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia","status":"RECRUITING","sponsor":"UMC Utrecht","startDate":"2016-04-11","conditions":"Community-acquired Pneumonia, Influenza, COVID-19","enrollment":20000},{"nctId":"NCT06484647","phase":"","title":"Comparing T-stenting And Minimal Protrusion With External Minicrush for Treatment of Complex Coronary Bifurcation","status":"RECRUITING","sponsor":"San Luigi Gonzaga Hospital","startDate":"2024-06-01","conditions":"Coronary Artery Disease, Ischemic Heart Disease, Chronic Coronary Syndrome","enrollment":382},{"nctId":"NCT05553613","phase":"PHASE3","title":"Ticagrelor Versus Clopidogrel in Ischemic Stroke","status":"COMPLETED","sponsor":"Kafrelsheikh University","startDate":"2022-10-01","conditions":"Ischemic Stroke","enrollment":900},{"nctId":"NCT05559918","phase":"","title":"Dual-antiplatelet Therapy Strategies for Elective PCI in a Real-world Setting","status":"RECRUITING","sponsor":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","startDate":"2022-10-01","conditions":"Coronary Artery Disease","enrollment":1462},{"nctId":"NCT06015477","phase":"NA","title":"Stent-Assisted Coiling Followed by Ticagrelor Monotherapy Instead of Dual Antiplatelet Therapy in Unruptured Intracranial Aneurysm","status":"RECRUITING","sponsor":"The First Affiliated Hospital with Nanjing Medical University","startDate":"2024-01-01","conditions":"Intracranial Aneurysm, Stent Complication","enrollment":180},{"nctId":"NCT05209412","phase":"NA","title":"Paclitaxel-Coated Balloon Versus Zotarolimus-Eluting Stent for Treatment of De Novo Coronary Artery Lesions","status":"UNKNOWN","sponsor":"Xijing Hospital","startDate":"2022-02-01","conditions":"De Novo Stenosis, Coronary Artery Disease, Percutaneous Coronary Intervention","enrollment":370},{"nctId":"NCT06120725","phase":"PHASE3","title":"Ticagrelor Versus Clopidogrel in Large Vessel Ischemic Stroke","status":"COMPLETED","sponsor":"Kafrelsheikh University","startDate":"2021-09-01","conditions":"Ischemic Stroke","enrollment":580},{"nctId":"NCT05700266","phase":"PHASE2, PHASE3","title":"Anticoagulation Using Rivaroxaban on Top of Aspirin in Intracranial Atherosclerotic Stenosis","status":"UNKNOWN","sponsor":"The First Affiliated Hospital with Nanjing Medical University","startDate":"2023-12-30","conditions":"Ischemic Stroke, Intracranial Atherosclerosis, Stenosis","enrollment":1180},{"nctId":"NCT04057300","phase":"PHASE4","title":"Ticagrelor Compared to Clopidogrel in Acute Coronary Syndromes","status":"COMPLETED","sponsor":"McGill University Health Centre/Research Institute of the McGill University Health Centre","startDate":"2018-10-01","conditions":"Acute Coronary Syndrome","enrollment":1038},{"nctId":"NCT01307657","phase":"NA","title":"Impact of a High-fat Meal on Assessment of Clopidogrel-induced Platelet Inhibition in Healthy Subjects","status":"COMPLETED","sponsor":"University of Nebraska","startDate":"2011-02-15","conditions":"Healthy","enrollment":12},{"nctId":"NCT00751231","phase":"PHASE2","title":"A Phase 2 Safety and Efficacy Study of PRT060128, a Novel Intravenous and Oral P2Y12 Inhibitor, in Non-Urgent PCI","status":"COMPLETED","sponsor":"Portola Pharmaceuticals","startDate":"2008-12","conditions":"Percutaneous Coronary Intervention","enrollment":652},{"nctId":"NCT05974033","phase":"NA","title":"IntraCranial Angiography-derived Fraction Flow-guided Percutaneous Transluminal Angioplasty and Stenting Versus Medical Therapy (ICAS-MT)","status":"NOT_YET_RECRUITING","sponsor":"Changhai Hospital","startDate":"2023-08","conditions":"ICAS - Intracranial Atherosclerosis","enrollment":536},{"nctId":"NCT05902000","phase":"NA","title":"Stent Implantation Versus Balloon Dilation for Acute Anterior Circulation Tandem Occlusion","status":"UNKNOWN","sponsor":"Xueli Cai","startDate":"2023-06-14","conditions":"Thrombectomy, Tandem Occlusion, Stroke","enrollment":222},{"nctId":"NCT03188705","phase":"PHASE4","title":"CES1 Carriers in the PAPI Study","status":"COMPLETED","sponsor":"University of Maryland, Baltimore","startDate":"2019-10-14","conditions":"Heart Diseases, Coronary Disease, Coronary Artery Disease","enrollment":6},{"nctId":"NCT04944615","phase":"NA","title":"To Evaluate Whether IVUS-guided Drug-eluting Stent (DES) Implantation Leads to Better Clinical Outcomes Compared to Conventional Angiography in the Treatment of Chronic Complete Occlusion (CTO) Disease.","status":"RECRUITING","sponsor":"CCRF Inc., Beijing, China","startDate":"2022-10-21","conditions":"Chronic Total Occlusion of Coronary Artery","enrollment":1448},{"nctId":"NCT02869009","phase":"PHASE3","title":"Antiplatelet Therapy in Acute Mild-Moderate Ischemic Stroke","status":"COMPLETED","sponsor":"General Hospital of Shenyang Military Region","startDate":"2016-11","conditions":"Ischemic Stroke","enrollment":3000},{"nctId":"NCT00992420","phase":"","title":"Genotype Information and Functional Testing Study","status":"COMPLETED","sponsor":"Scripps Health","startDate":"2009-10-01","conditions":"Coronary Artery Disease","enrollment":2000},{"nctId":"NCT05554822","phase":"PHASE3","title":"Head-to-head Comparison of Single Versus Dual Antiplatelet Treatment Strategy After Percutaneous Left Atrial Appendage Closure: a Multicenter, Randomized Study","status":"UNKNOWN","sponsor":"Azienda Ospedaliero Universitaria Maggiore della Carita","startDate":"2021-06-14","conditions":"Left Atrial Appendage Occlusion, Antiplatelet Therapy","enrollment":574},{"nctId":"NCT03207451","phase":"PHASE4","title":"Vorapaxar on Thrombin Generation and Coagulability","status":"COMPLETED","sponsor":"Inova Health Care Services","startDate":"2016-01-01","conditions":"Coronary Artery Disease, Peripheral Vascular Disease, Myocardial Infarction","enrollment":81},{"nctId":"NCT02197039","phase":"","title":"The Selection Criteria for the Second-look Endoscopy Among Patients With Bleeding Peptic Ulcers","status":"COMPLETED","sponsor":"National Cheng-Kung University Hospital","startDate":"2011-08","conditions":"Peptic Ulcer Hemorrhage","enrollment":316},{"nctId":"NCT02486367","phase":"PHASE4","title":"Inflammation and Thrombosis in Patients With Severe Aortic Stenosis After Transcatheter Aortic Valve Replacement (TAVR)","status":"COMPLETED","sponsor":"University Hospitals Cleveland Medical Center","startDate":"2015-06","conditions":"Aortic Stenosis, Inflammation, Thrombosis","enrollment":60},{"nctId":"NCT04491695","phase":"PHASE2, PHASE3","title":"Tirofiban for the Prevention of Neurological Deterioration in Acute Ischemic Stroke","status":"UNKNOWN","sponsor":"Capital Medical University","startDate":"2020-09-12","conditions":"Acute Stroke","enrollment":420},{"nctId":"NCT02677545","phase":"PHASE2","title":"Ticagrelor Versus Clopidogrel in Carotid Artery Stenting","status":"COMPLETED","sponsor":"University Hospital, Basel, Switzerland","startDate":"2016-12","conditions":"Carotid Artery Stenosis","enrollment":210},{"nctId":"NCT04331145","phase":"PHASE4","title":"Platelet REACtivity According to TICagrelor Dose After Transcatheter AorticValve Implantation","status":"COMPLETED","sponsor":"Andres Iñiguez Romo","startDate":"2020-06-23","conditions":"Symptomatic Aortic Stenosis","enrollment":40},{"nctId":"NCT03701360","phase":"","title":"Anti-platelet Precision Medicine to Prevent Stroke Early Progression and Recurrence (PRECISE)","status":"COMPLETED","sponsor":"Asan Medical Center","startDate":"2018-10-30","conditions":"Stroke","enrollment":1199},{"nctId":"NCT02817789","phase":"PHASE3","title":"Safety Profile Evaluation of TICagrelor Alone Compared to a Combination of Lysine Acetylsalicylate-Clopidogrel in the Context of Transcatheter Aortic Valve Implantation (TAVI)","status":"COMPLETED","sponsor":"University Hospital, Bordeaux","startDate":"2016-05-09","conditions":"Aortic Valve Stenosis","enrollment":50},{"nctId":"NCT04078737","phase":"PHASE3","title":"Clopidogrel With Aspirin in High-risk Patients With Acute Non-disabling Cerebrovascular Events II","status":"COMPLETED","sponsor":"Beijing Tiantan Hospital","startDate":"2019-09-23","conditions":"Stroke, Transient Ischemic Attack","enrollment":6412},{"nctId":"NCT03437044","phase":"PHASE4","title":"Low Maintenance Dose Ticagrelor Versus Clopidogrel in Diabetes Patients Undergoing PCI","status":"COMPLETED","sponsor":"University of Florida","startDate":"2018-03-14","conditions":"Diabetes Mellitus, Type 2, Coronary Artery Disease","enrollment":40},{"nctId":"NCT04695106","phase":"PHASE4","title":"Dual Antithrombotic Therapy With Dabigatran and Ticagrelor in Patients With ACS and Non-valvular AF Undergoing PCI","status":"RECRUITING","sponsor":"Medical University of Gdansk","startDate":"2021-10-25","conditions":"Atrial Fibrillation, Antithrombotic Therapy, Acute Coronary Syndrome","enrollment":2230},{"nctId":"NCT01846559","phase":"PHASE4","title":"The Antiplatelet and Immune Response Trial","status":"COMPLETED","sponsor":"Sheffield Teaching Hospitals NHS Foundation Trust","startDate":"2013-04","conditions":"Healthy","enrollment":30},{"nctId":"NCT05045274","phase":"NA","title":"The Effect of Early Administration of Dapagliflozin in STEMI Patients With LV Systolic Dysfunction","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2021-12","conditions":"STEMI - ST Elevation Myocardial Infarction, Left Ventricular Systolic Dysfunction","enrollment":300},{"nctId":"NCT02639143","phase":"PHASE4","title":"Rapid P2Y12 Receptor Inhibition Attenuates Inflammatory Cell Infiltration in Thrombus Aspirated From the STEMI Patients","status":"COMPLETED","sponsor":"First Affiliated Hospital of Harbin Medical University","startDate":"2015-12","conditions":"Inflammation, Thrombosis","enrollment":50},{"nctId":"NCT04984135","phase":"","title":"DCB Angioplasty for Coronary Lesions: an OCT Analysis","status":"COMPLETED","sponsor":"The First Affiliated Hospital of Dalian Medical University","startDate":"2020-12-01","conditions":"Coronary Stenosis, Drug-coated Balloon","enrollment":70},{"nctId":"NCT02989558","phase":"PHASE3","title":"A Trial to Assess the Safety and Efficacy of Prophylactic TicagrelOr With Acetylsalicylic Acid Versus CLopidogrel With Acetylsalicylic Acid in the Development of Cerebrovascular EMbolic Events During TAVI","status":"COMPLETED","sponsor":"University of Athens","startDate":"2016-12","conditions":"Aortic Valve Stenosis","enrollment":90},{"nctId":"NCT03533153","phase":"PHASE1, PHASE2","title":"Intravenous MSC Therapy on Ischemia-Reperfusion Injury in Patients With Myocardial Infarction","status":"UNKNOWN","sponsor":"The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School","startDate":"2021-03-01","conditions":"Myocardial Infarction","enrollment":90},{"nctId":"NCT04671069","phase":"PHASE1","title":"Drug Interaction Study of MGL-3196 With Clopidogrel","status":"COMPLETED","sponsor":"Madrigal Pharmaceuticals, Inc.","startDate":"2019-07-26","conditions":"Healthy","enrollment":20},{"nctId":"NCT02931045","phase":"PHASE4","title":"Antiplatelet Therapy Effect on Extracellular Vesicles in Acute Myocardial Infarction","status":"COMPLETED","sponsor":"Medical University of Warsaw","startDate":"2017-12-30","conditions":"Myocardial Infarction","enrollment":60},{"nctId":"NCT02618837","phase":"PHASE4","title":"Downstream Versus Upstream Strategy for the Administration of P2Y12 Receptor Blockers","status":"UNKNOWN","sponsor":"University of Padova","startDate":"2015-12-14","conditions":"Unstable Angina or Non ST Elevated Myocardial Infarction","enrollment":2520},{"nctId":"NCT02701140","phase":"PHASE2, PHASE3","title":"Ticagrelor And PrEconditioning in Patients With coronaRy Artery diSease","status":"COMPLETED","sponsor":"Italo Porto","startDate":"2016-06","conditions":"Myocardial Ischemia","enrollment":58},{"nctId":"NCT02617290","phase":"PHASE3","title":"Assessment of Loading With the P2Y12 Inhibitor Ticagrelor or Clopidogrel to Halt Ischemic Events in Patients Undergoing Elective Coronary Stenting","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2017-01-09","conditions":"Coronary Artery Disease, Myocardial Ischemia, Myocardial Infarction","enrollment":1900},{"nctId":"NCT03489863","phase":"PHASE4","title":"Prasugrel Versus Ticagrelor in Patients With CYP2C19 Loss-of-function: a Validation Study","status":"COMPLETED","sponsor":"University of Florida","startDate":"2018-05-30","conditions":"Coronary Artery Disease","enrollment":14},{"nctId":"NCT01365221","phase":"PHASE4","title":"The Effect of Reloading Prasugrel in a Patient Who Has Already Received a Loading Dose (LD) of Clopidogrel","status":"COMPLETED","sponsor":"Medstar Health Research Institute","startDate":"2010-10","conditions":"Acute Coronary Syndrome","enrollment":77},{"nctId":"NCT04116931","phase":"PHASE4","title":"OPTImal Management of Antithrombotic Agents: OPTIMA-5","status":"UNKNOWN","sponsor":"The First Affiliated Hospital with Nanjing Medical University","startDate":"2020-06-22","conditions":"Acute Coronary Syndrome (ACS)","enrollment":80},{"nctId":"NCT02944123","phase":"PHASE3","title":"Half Dose of Prasugrel and Ticagrelor in Acute Coronary Syndrome (HOPE-TAILOR)","status":"COMPLETED","sponsor":"Dong-A University","startDate":"2016-09","conditions":"Acute Coronary Syndrome","enrollment":120},{"nctId":"NCT02506140","phase":"PHASE2, PHASE3","title":"Platelet Reactivity in Acute Non-disabling Cerebrovascular Events","status":"COMPLETED","sponsor":"Beijing Tiantan Hospital","startDate":"2015-08","conditions":"Stroke, Ischemic Attack, Transient","enrollment":675},{"nctId":"NCT03552354","phase":"PHASE4","title":"Argatroban Combined With Antiplatelet Versus Antiplatelet for Acute Ischemic Stroke","status":"COMPLETED","sponsor":"General Hospital of Shenyang Military Region","startDate":"2017-10-25","conditions":"Stroke, Ischemic","enrollment":120},{"nctId":"NCT02548611","phase":"PHASE4","title":"Comparison of Loading Strategies With Antiplatelet Drugs in Patients Undergoing Elective Coronary Intervention","status":"TERMINATED","sponsor":"LMU Klinikum","startDate":"2015-09","conditions":"Angina Pectoris","enrollment":795},{"nctId":"NCT00979589","phase":"PHASE3","title":"Clopidogrel in High-risk Patients With Acute Non-disabling Cerebrovascular Events","status":"COMPLETED","sponsor":"Beijing Tiantan Hospital","startDate":"2009-12","conditions":"Stroke, Transient Ischemic Attack","enrollment":5100},{"nctId":"NCT04431349","phase":"","title":"Comparison of CABG Related Bleeding Complications in Patients Treated With Ticagrelor or Clopidogrel","status":"COMPLETED","sponsor":"Ajou University School of Medicine","startDate":"2016-01-01","conditions":"Blood Loss, Surgical, Ticagrelor, Clopidogrel","enrollment":1097},{"nctId":"NCT04407312","phase":"PHASE4","title":"Cilostazol and Endothelial Progenitor Cell","status":"UNKNOWN","sponsor":"Gyeongsang National University Hospital","startDate":"2016-01-01","conditions":"Myocardial Infarction, Acute","enrollment":60},{"nctId":"NCT03867461","phase":"NA","title":"The Effects of MAP and EtCO2 on Venous Sinus Pressures","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2019-06-20","conditions":"Idiopathic Intracranial Hypertension","enrollment":8},{"nctId":"NCT02247128","phase":"PHASE4","title":"Antiplatelet Therapy for Patients Undergoing Transcatheter Aortic Valve Implantation","status":"COMPLETED","sponsor":"St. Antonius Hospital","startDate":"2014-01","conditions":"Aortic Valve Disease, Myocardial Infarction, Stroke","enrollment":1016},{"nctId":"NCT04368377","phase":"PHASE2","title":"Enhanced Platelet Inhibition in Critically Ill Patients With COVID-19","status":"COMPLETED","sponsor":"University of Milan","startDate":"2020-04-06","conditions":"Pneumonia, Viral, Corona Virus Infection, Respiratory Failure","enrollment":5},{"nctId":"NCT03039205","phase":"PHASE2","title":"Platelet Aggregation in Patients With Coronary Artery Disease and Kidney Dysfunction Taking Clopidogrel or Ticagrelor","status":"COMPLETED","sponsor":"University of Sao Paulo","startDate":"2017-11-07","conditions":"Platelet Aggregation, Adenosine, Coronary Artery Disease","enrollment":90},{"nctId":"NCT04267224","phase":"","title":"Early Versus Late Loading of Ticagrelol in Patients With STEMI","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2020-03-01","conditions":"Myocardial Infarction","enrollment":800},{"nctId":"NCT02376283","phase":"PHASE4","title":"P3AMI Antiplatelet Trial","status":"COMPLETED","sponsor":"The Royal Wolverhampton Hospitals NHS Trust","startDate":"2015-03-09","conditions":"Heart Attack","enrollment":87},{"nctId":"NCT02086903","phase":"PHASE3","title":"Clopidogrel And Ticagrelor in Healthy Subjects","status":"COMPLETED","sponsor":"Dong-A University","startDate":"2014-02","conditions":"Pharmacodynamics","enrollment":12}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":339,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Clopidogrel loading","genericName":"Clopidogrel loading","companyName":"Azienda Policlinico Umberto I","companyId":"azienda-policlinico-umberto-i","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Clopidogrel is a prodrug that irreversibly inhibits platelet aggregation by blocking the P2Y12 adenosine diphosphate receptor. Used for Acute coronary syndrome (unstable angina, NSTEMI, STEMI), Secondary prevention of atherothrombotic events in patients with recent myocardial infarction, stroke, or peripheral arterial disease.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}