{"id":"clopamide","rwe":[{"pmid":"35559154","year":"2022","title":"Photodegradation and In Silico Molecular Docking Study of a Diuretic Drug: Clopamide.","finding":"","journal":"ACS omega","studyType":"Clinical Study"},{"pmid":"30010836","year":"2018","title":"Validation of a rapid and simple high-performance liquid chromatography-electrospray ionization-mass spectrometry method for simultaneous analysis of 15 key chemicals in slimming foods and herbal products.","finding":"","journal":"Journal of chromatographic science","studyType":"Clinical Study"},{"pmid":"27037980","year":"2016","title":"Validated liquid chromatography-tandem mass spectrometry method for simultaneous determination of clopamide, reserpine and dihydroergotoxine: Application to pharmacokinetics in human plasma.","finding":"","journal":"Journal of pharmaceutical and biomedical analysis","studyType":"Clinical Study"},{"pmid":"25019556","year":"2014","title":"Computer aided screening of secreted frizzled-related protein 4 (SFRP4): a potential control for diabetes mellitus.","finding":"","journal":"Molecules (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"23144763","year":"2012","title":"Diuretics prime plant immunity in Arabidopsis thaliana.","finding":"","journal":"PloS one","studyType":"Clinical Study"}],"tags":[{"label":"clopamide","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"C03BA03","category":"atc"},{"label":"Active","category":"status"},{"label":"Diuretics","category":"pharmacology"},{"label":"Natriuretic Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"brinaldix","offLabel":[],"synonyms":["brinedine","clopamide","chlosudimeprimyl","clopamidum","brinaldix"],"timeline":[],"approvals":[],"brandName":"Brinaldix","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"clopamide","explanation":"Think of it like a faucet - when you turn the faucet on, water flows out. In the kidneys, there's a 'faucet' that controls how much water is reabsorbed back into the body. Brinaldix turns down this faucet, allowing more water to be excreted in the urine, which helps to reduce excessive thirst and urination.","oneSentence":"Brinaldix works by inhibiting the reabsorption of water in the kidneys, allowing the body to excrete excess fluids.","technicalDetail":"Brinaldix acts as a selective inhibitor of the sodium-potassium-chloride cotransporter (NKCC2) in the thick ascending limb of the loop of Henle, reducing the reabsorption of sodium, potassium, and chloride ions, and subsequently water, in the kidneys."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Clopamide","title":"Clopamide","extract":"Clopamide is a piperidine diuretic."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/706","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CLOPAMIDE","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Clopamide","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T10:13:00.512391","biosimilars":[],"competitors":[{"drugName":"quinethazone","drugSlug":"quinethazone","fdaApproval":"1963-04-10","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"chlortalidone","drugSlug":"chlortalidone","fdaApproval":"1960-04-07","relationship":"same-class"},{"drugName":"metolazone","drugSlug":"metolazone","fdaApproval":"1973-11-27","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"indapamide","drugSlug":"indapamide","fdaApproval":"1983-07-06","genericCount":7,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"clopamide","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"quinethazone","brandName":"quinethazone","genericName":"quinethazone","approvalYear":"1963","relationship":"same-class"},{"drugId":"chlortalidone","brandName":"chlortalidone","genericName":"chlortalidone","approvalYear":"1960","relationship":"same-class"},{"drugId":"metolazone","brandName":"metolazone","genericName":"metolazone","approvalYear":"1973","relationship":"same-class"},{"drugId":"indapamide","brandName":"indapamide","genericName":"indapamide","approvalYear":"1983","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000167202","NDDF":"003711","UNII":"17S83WON0I","CHEBI":"CHEBI:94521","INN_ID":"1517","RXNORM":"2603","UMLSCUI":"C0009025","ChEMBL_ID":"CHEMBL1361347","KEGG_DRUG":"D02460","DRUGBANK_ID":"DB13792","PUBCHEM_CID":"12492","SNOMEDCT_US":"395940005","MESH_DESCRIPTOR_UI":"D003005"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":149,"therapeuticAreas":["Nephrology"],"atcClassification":{"source":"DrugCentral","atcCode":"C03BA03","allCodes":["C03BA03","C03BB03"]},"biosimilarFilings":[],"recentPublications":[{"date":"2022 Apr 26","pmid":"35559154","title":"Photodegradation and In Silico Molecular Docking Study of a Diuretic Drug: Clopamide.","journal":"ACS omega"},{"date":"2018 Nov 1","pmid":"30010836","title":"Validation of a rapid and simple high-performance liquid chromatography-electrospray ionization-mass spectrometry method for simultaneous analysis of 15 key chemicals in slimming foods and herbal products.","journal":"Journal of chromatographic science"},{"date":"2016 Jun 5","pmid":"27037980","title":"Validated liquid chromatography-tandem mass spectrometry method for simultaneous determination of clopamide, reserpine and dihydroergotoxine: Application to pharmacokinetics in human plasma.","journal":"Journal of pharmaceutical and biomedical analysis"},{"date":"2014 Jul 11","pmid":"25019556","title":"Computer aided screening of secreted frizzled-related protein 4 (SFRP4): a potential control for diabetes mellitus.","journal":"Molecules (Basel, Switzerland)"},{"date":"2012","pmid":"23144763","title":"Diuretics prime plant immunity in Arabidopsis thaliana.","journal":"PloS one"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Brinaldix is a small molecule modality. It is also known by the synonyms AQUEX, CLOPAMIDA, CLOPAMIDE, and DT-327.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}