{"id":"clonitrate","rwe":[{"pmid":"14287366","year":"1965","title":"CLINICAL EVALUATION OF CLONITRATE IN PATIENTS WITH ANGINA PECTORIS.","finding":"","journal":"Medical times","studyType":"Clinical Study"},{"pmid":"14284272","year":"1965","title":"THE ONSET AND DURATION OF ACTION OF CLONITRATE AS MEASURED BY THE BALLISTOCARDIOGRAPHIC RESPONSE.","finding":"","journal":"Angiology","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Angina pectoris","category":"indication"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"dinitrochlorhydrin","offLabel":[],"synonyms":["clonitrate","dinitrochlorhydrin","dinitrochlorohydrin"],"timeline":[],"approvals":[],"brandName":"Dinitrochlorhydrin","ecosystem":[{"indication":"Angina pectoris","otherDrugs":[{"name":"amlodipine","slug":"amlodipine","company":"Pfizer"},{"name":"atenolol","slug":"atenolol","company":"Alvogen Ipco Sarl"},{"name":"atorvastatin","slug":"atorvastatin","company":"Pfizer"},{"name":"bepridil","slug":"bepridil","company":""}],"globalPrevalence":112000000}],"mechanism":{"modality":"Small Molecule","explanation":"Imagine your blood vessels as roads that allow traffic to flow to your heart. Clonitrate helps to widen these roads, making it easier for blood to reach your heart and reducing the strain on your heart muscle. This can help to alleviate symptoms of angina pectoris, such as chest pain and shortness of breath.","oneSentence":"Clonitrate works by relaxing blood vessels to improve blood flow to the heart.","technicalDetail":"Clonitrate exerts its effects through a mechanism that involves the relaxation of vascular smooth muscle, leading to vasodilation and increased blood flow to the myocardium."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3110","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CLONITRATE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:12:53.709509","biosimilars":[],"competitors":[],"genericName":"clonitrate","indications":{"approved":[{"name":"Angina pectoris","source":"DrugCentral","snomedId":194828000,"regulator":"FDA","usPrevalence":null,"globalPrevalence":112000000,"prevalenceMethod":"curated","prevalenceSource":"WHO, 2023"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"MIG1YFL8MD","CHEBI":"CHEBI:134862","INN_ID":"1458","RXNORM":"2372697","UMLSCUI":"C2825370","ChEMBL_ID":"CHEMBL2104377","KEGG_DRUG":"D03553","PUBCHEM_CID":"17468"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":2,"therapeuticAreas":["Cardiovascular"],"biosimilarFilings":[],"recentPublications":[{"date":"1965 Jun","pmid":"14287366","title":"CLINICAL EVALUATION OF CLONITRATE IN PATIENTS WITH ANGINA PECTORIS.","journal":"Medical times"},{"date":"1965 May","pmid":"14284272","title":"THE ONSET AND DURATION OF ACTION OF CLONITRATE AS MEASURED BY THE BALLISTOCARDIOGRAPHIC RESPONSE.","journal":"Angiology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dinitrochlorhydrin is a small molecule with the synonyms CLONITRATE, CLONITRATO, and DYLATE.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}