{"id":"clomocycline","rwe":[{"pmid":"6615686","year":"1983","title":"Some tetracycline drugs suppress mitogen-stimulated lymphocyte growth but others do not.","finding":"","journal":"British journal of clinical pharmacology","studyType":"Clinical Study"},{"pmid":"788767","year":"1976","title":"A double-blind trial of clomocycline in the treatment of persistent palmoplantar pustulosis.","finding":"","journal":"The British journal of dermatology","studyType":"Clinical Study"},{"pmid":"4892122","year":"1969","title":"Clinical trial of clomocycline (Megaclor) in gonococcal and non-gonococcal urethritis.","finding":"","journal":"The British journal of venereal diseases","studyType":"Clinical Study"},{"pmid":"5672548","year":"1968","title":"The use of clomocycline ('Megaclor') in acute respiratory infections.","finding":"","journal":"The British journal of clinical practice","studyType":"Clinical Study"},{"pmid":"4234717","year":"1968","title":"Clomocycline and oxytetracycline in acne vulgaris.","finding":"","journal":"The Practitioner","studyType":"Clinical Study"}],"tags":[{"label":"clomocycline","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"J01AA11","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"chlormethylenecycline","offLabel":[],"synonyms":["clomocycline","chlormethylenecycline"],"timeline":[],"approvals":[],"brandName":"Chlormethylenecycline","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"clomocycline","explanation":"Imagine your body's cells are like factories that make copies of themselves. Bacteria are like tiny factories that make copies of themselves too, but they can cause harm. Clomocycline is like a tool that disrupts the bacterial factories, making it harder for them to make copies of themselves and eventually killing them off.","oneSentence":"Clomocycline works by interfering with bacterial DNA replication, ultimately inhibiting the growth and spread of bacteria.","technicalDetail":"Clomocycline is a bacteriostatic agent that likely inhibits DNA replication by binding to the bacterial DNA gyrase or topoisomerase, preventing the unwinding of DNA and thereby inhibiting bacterial growth and replication."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/702","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CLOMOCYCLINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:11:37.625404","biosimilars":[],"competitors":[{"drugName":"demeclocycline","drugSlug":"demeclocycline","fdaApproval":"1960-01-14","genericCount":4,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"doxycycline","drugSlug":"doxycycline","fdaApproval":"1967-12-05","patentExpiry":"Dec 19, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"chlortetracycline","drugSlug":"chlortetracycline","fdaApproval":"1950-01-23","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"metacycline","drugSlug":"metacycline","fdaApproval":"","relationship":"same-class"},{"drugName":"oxytetracycline","drugSlug":"oxytetracycline","fdaApproval":"1964-09-08","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"tetracycline","drugSlug":"tetracycline","fdaApproval":"1953-11-19","genericCount":34,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"minocycline","drugSlug":"minocycline","fdaApproval":"1971-06-30","patentExpiry":"Sep 8, 2037","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"tigecycline","drugSlug":"tigecycline","fdaApproval":"2005-06-15","patentExpiry":"Oct 8, 2030","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"sarecycline","drugSlug":"sarecycline","fdaApproval":"2018-10-01","patentExpiry":"Jan 3, 2032","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"omadacycline","drugSlug":"omadacycline","fdaApproval":"2018-10-02","patentExpiry":"Sep 23, 2030","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"clomocycline","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"demeclocycline","brandName":"demeclocycline","genericName":"demeclocycline","approvalYear":"1960","relationship":"same-class"},{"drugId":"doxycycline","brandName":"doxycycline","genericName":"doxycycline","approvalYear":"1967","relationship":"same-class"},{"drugId":"chlortetracycline","brandName":"chlortetracycline","genericName":"chlortetracycline","approvalYear":"1950","relationship":"same-class"},{"drugId":"metacycline","brandName":"metacycline","genericName":"metacycline","approvalYear":"","relationship":"same-class"},{"drugId":"oxytetracycline","brandName":"oxytetracycline","genericName":"oxytetracycline","approvalYear":"1964","relationship":"same-class"},{"drugId":"tetracycline","brandName":"tetracycline","genericName":"tetracycline","approvalYear":"1953","relationship":"same-class"},{"drugId":"minocycline","brandName":"minocycline","genericName":"minocycline","approvalYear":"1971","relationship":"same-class"},{"drugId":"tigecycline","brandName":"tigecycline","genericName":"tigecycline","approvalYear":"2005","relationship":"same-class"},{"drugId":"sarecycline","brandName":"sarecycline","genericName":"sarecycline","approvalYear":"2018","relationship":"same-class"},{"drugId":"omadacycline","brandName":"omadacycline","genericName":"omadacycline","approvalYear":"2018","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"005557","UNII":"YP0241BU76","CHEBI":"CHEBI:59589","INN_ID":"2151","RXNORM":"21272","UMLSCUI":"C0055923","ChEMBL_ID":"CHEMBL2106071","KEGG_DRUG":"D06885","DRUGBANK_ID":"DB00453","PUBCHEM_CID":"54680675","SNOMEDCT_US":"419950007","MESH_SUPPLEMENTAL_RECORD_UI":"C007090"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":8,"therapeuticAreas":["Infectious Disease"],"atcClassification":{"source":"DrugCentral","atcCode":"J01AA11","allCodes":["J01AA11"]},"biosimilarFilings":[],"recentPublications":[{"date":"1983 Aug","pmid":"6615686","title":"Some tetracycline drugs suppress mitogen-stimulated lymphocyte growth but others do not.","journal":"British journal of clinical pharmacology"},{"date":"1976 Sep","pmid":"788767","title":"A double-blind trial of clomocycline in the treatment of persistent palmoplantar pustulosis.","journal":"The British journal of dermatology"},{"date":"1969 Jun","pmid":"4892122","title":"Clinical trial of clomocycline (Megaclor) in gonococcal and non-gonococcal urethritis.","journal":"The British journal of venereal diseases"},{"date":"1968 Sep","pmid":"5672548","title":"The use of clomocycline ('Megaclor') in acute respiratory infections.","journal":"The British journal of clinical practice"},{"date":"1968 Sep","pmid":"4234717","title":"Clomocycline and oxytetracycline in acne vulgaris.","journal":"The Practitioner"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Chlormethylenecycline, also known as Clomocycline, is a small molecule antibiotic in the clomocycline drug class. Its mechanism of action is not well-documented, but it is believed to target bacterial DNA replication. Clomocycline is not FDA-approved for any indications, and its commercial status is unknown. As a result, there is limited information available on its safety profile and potential side effects. Further research is needed to fully understand the properties and potential uses of Clomocycline.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}