{"id":"clomiphene-citrate-hcg","safety":{"commonSideEffects":[{"rate":"1-10%","effect":"Ovarian hyperstimulation syndrome (OHSS)"},{"rate":"10-20%","effect":"Hot flashes"},{"rate":"5-15%","effect":"Abdominal bloating and discomfort"},{"rate":"5-10%","effect":"Nausea"},{"rate":"1-3%","effect":"Visual disturbances"},{"rate":"5-10%","effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Clomiphene citrate is a selective estrogen receptor modulator that blocks negative feedback of estrogen on the hypothalamic-pituitary axis, increasing FSH and LH secretion to stimulate follicle development. Human chorionic gonadotropin (hCG) is then administered to mimic the LH surge, triggering final oocyte maturation and ovulation. This combination is used in assisted reproductive technology protocols to control the timing and synchronization of ovulation.","oneSentence":"Clomiphene citrate stimulates gonadotropin release to promote ovulation, while hCG triggers final oocyte maturation and ovulation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:18:53.907Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Anovulation and infertility in women undergoing assisted reproductive technology (ART)"},{"name":"Controlled ovarian hyperstimulation for in vitro fertilization (IVF)"}]},"trialDetails":[{"nctId":"NCT04983173","phase":"PHASE4","title":"INTEnsity of ovariaN Stimulation and Embryo Quality","status":"RECRUITING","sponsor":"Fundación Santiago Dexeus Font","startDate":"2021-11-23","conditions":"Infertility","enrollment":110},{"nctId":"NCT06934785","phase":"NA","title":"LE + CC vs. LE for Ovulation Induction","status":"RECRUITING","sponsor":"Mỹ Đức Hospital","startDate":"2025-04-28","conditions":"Letrozole, Clomiphene Citrate, Ovulation Disorder","enrollment":600},{"nctId":"NCT06635538","phase":"NA","title":"One-shot Ovarian Stimulation Protocol (One-shot)","status":"RECRUITING","sponsor":"Fundación Santiago Dexeus Font","startDate":"2024-10-31","conditions":"Infertility, Female","enrollment":20},{"nctId":"NCT06418347","phase":"PHASE3","title":"Effect of ALA Combined With Letrozole on Polycystic Ovary Syndrome Clinical Outcome in Infertile Females","status":"RECRUITING","sponsor":"Ain Shams University","startDate":"2024-04-01","conditions":"Polycystic Ovary Syndrome, Infertility, Female","enrollment":150},{"nctId":"NCT06178523","phase":"PHASE4","title":"Cost-effective Treatment of Unexplained Infertility","status":"COMPLETED","sponsor":"Batterjee Medical College","startDate":"2024-01-01","conditions":"Unexplained Infertility","enrollment":900},{"nctId":"NCT06778733","phase":"EARLY_PHASE1","title":"Effectiveness of Low Dose 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of Clomiphene Citrate Ovulation Induction on Frozen Embryo Transfer","status":"UNKNOWN","sponsor":"ShangHai Ji Ai Genetics & IVF Institute","startDate":"2017-08-07","conditions":"Infertility, Female, Clomiphene Citrate","enrollment":360},{"nctId":"NCT02264847","phase":"PHASE3","title":"Human Chorionic Gonadotrophin & Trigger","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2014-10","conditions":"Ovulation Disorder","enrollment":200},{"nctId":"NCT02690870","phase":"PHASE4","title":"Tamoxifen and Clomiphene Citrate in Mild Stimulation IVF","status":"UNKNOWN","sponsor":"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University","startDate":"2017-01","conditions":"Infertility","enrollment":210},{"nctId":"NCT02638285","phase":"PHASE4","title":"Pregnancy Rate by HCG Administration Versus Urinary LH Surge Method in Patients Undergoing IUI","status":"COMPLETED","sponsor":"Shiraz University of Medical 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Used for Anovulation and infertility in women undergoing assisted reproductive technology (ART), Controlled ovarian hyperstimulation for in vitro fertilization (IVF).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}