{"id":"clofibrate-clofibrate","safety":{"commonSideEffects":["Nausea","Diarrhea","Abdominal pain","Myalgia","Fatigue","Rash"],"contraindications":["Hepatic dysfunction","Severe renal dysfunction","Primary biliary cirrhosis","Pregnancy","Gallbladder disease"]},"_chembl":null,"modality":"Small molecule","_dailymed":null,"mechanism":{"target":"PPAR-α (peroxisome proliferator-activated receptor alpha)","explanation":"Clofibrate is a prodrug that is hydrolyzed to clofibric acid, which activates PPAR-α nuclear receptors. This activation increases the expression of lipoprotein lipase, enhances fatty acid oxidation, and reduces hepatic triglyceride production, ultimately lowering serum triglycerides and VLDL cholesterol levels.","oneSentence":"Clofibrate activates peroxisome proliferator-activated receptor alpha (PPAR-α) to increase lipoprotein lipase activity and reduce triglyceride levels."},"_scrapedAt":"2026-03-28T01:06:23.101Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"_claudeStub":{"ts":1779122668,"model":"claude-sonnet-4-5-20250929"},"competitors":[{"name":"gemfibrozil","brand":"Lopid","company":"Parke-Davis","rationale":"Fibric acid derivative for hypertriglyceridemia with better safety profile"},{"name":"fenofibrate","brand":"Tricor","company":"AbbVie","rationale":"Newer fibrate with improved efficacy and tolerability"},{"name":"niacin","brand":"Niaspan","company":"AbbVie","rationale":"Alternative lipid-lowering agent for triglycerides and HDL modification"},{"name":"omega-3 fatty acids","brand":"Lovaza","company":"GlaxoSmithKline","rationale":"Triglyceride-lowering therapy with cardiovascular benefits"}],"description":"Clofibrate is a fibric acid derivative lipid-lowering agent that was historically used to reduce cholesterol and triglyceride levels. It works by activating peroxisome proliferator-activated receptors to modify lipid metabolism. Due to safety concerns, it has been largely withdrawn from most markets.","indications":{"approved":[{"status":"approved","condition":"Hypertriglyceridemia","patientPopulation":"Adults with elevated triglyceride levels"},{"status":"approved","condition":"Type III hyperlipoproteinemia","patientPopulation":"Adults with dysbetalipoproteinemia"},{"status":"approved","condition":"Mixed hyperlipidemia","patientPopulation":"Adults inadequately responsive to diet"}]},"trialDetails":[{"nctId":"NCT00000482","phase":"PHASE3","title":"Coronary Drug Project","status":"COMPLETED","sponsor":"National Heart, Lung, and Blood Institute (NHLBI)","startDate":"1965-04","conditions":"Cardiovascular Diseases, Coronary Disease, Heart Diseases","enrollment":""},{"nctId":"NCT00000483","phase":"NA","title":"Coronary Drug Project Mortality Surveillance","status":"COMPLETED","sponsor":"National Heart, Lung, and Blood Institute (NHLBI)","startDate":"1981-06","conditions":"Cardiovascular Diseases, Coronary Disease, Heart Diseases","enrollment":""}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"BLOOD CREATININE INCREASED"},{"count":1,"reaction":"BLOOD UREA INCREASED"},{"count":1,"reaction":"DECREASED APPETITE"},{"count":1,"reaction":"DIARRHOEA"},{"count":1,"reaction":"HYPOTENSION"},{"count":1,"reaction":"INCORRECT DOSE ADMINISTERED"},{"count":1,"reaction":"NAUSEA"},{"count":1,"reaction":"VOMITING"}],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"clofibrate clofibrate","genericName":"clofibrate clofibrate","companyName":"National Heart, Lung, and Blood Institute (NHLBI)","companyId":"national-heart-lung-and-blood-institute-nhlbi","firstApprovalDate":"","aiSummary":"","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}