{"id":"clofezone","rwe":[{"pmid":"30000341","year":"2006","title":"Rabeprazole.","finding":"","journal":"","studyType":"Clinical Study"},{"pmid":"3238371","year":"1988","title":"The influence of NSAIDs on morphology of articular cartilage.","finding":"","journal":"Scandinavian journal of rheumatology. Supplement","studyType":"Clinical Study"},{"pmid":"6241720","year":"1984","title":"[Comparative studies on the bioavailability of various drug forms of phenylbutazone and clofezone (Perclusone)].","finding":"","journal":"Die Pharmazie","studyType":"Clinical Study"},{"pmid":"6241218","year":"1984","title":"[Clofezone and oxyphenbutazone excluded from dental use].","finding":"","journal":"Nihon Shika Ishikai zasshi","studyType":"Clinical Study"},{"pmid":"153678","year":"1978","title":"[Animal experiment studies on the effect of intra-articular injections of antiphlogistic-antirheumatic agents on articular cartilage in vivo].","finding":"","journal":"Zeitschrift fur Rheumatologie","studyType":"Clinical Study"}],"tags":[{"label":"clofezone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"M01AA05","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"clofezon","offLabel":[],"synonyms":["clofezone","clofezon","percluson","perclusone","clofexamide-phenylbutazone"],"timeline":[],"approvals":[],"brandName":"Clofezon","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"clofezone","explanation":"Imagine your body's cells have locks on them, and the key to unlocking these locks is a specific molecule. Clofezone is designed to mimic this key, allowing it to bind to the lock and trigger a response that can help treat a particular condition. This process is known as a molecular interaction, and it's a fundamental way that many medications work.","oneSentence":"Clofezone works by interacting with a specific molecular target to produce a therapeutic effect.","technicalDetail":"Clofezone is a small molecule that binds to a specific protein target, modulating its activity and producing a therapeutic effect. The exact nature of this interaction is not specified, but it is likely to involve a change in the protein's conformation or activity, leading to a downstream effect on cellular function."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4335","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CLOFEZONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:10:39.557533","biosimilars":[],"competitors":[{"drugName":"phenylbutazone","drugSlug":"phenylbutazone","fdaApproval":"1980-01-10","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"oxyphenbutazone","drugSlug":"oxyphenbutazone","fdaApproval":"1960-12-21","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"clofezone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"phenylbutazone","brandName":"phenylbutazone","genericName":"phenylbutazone","approvalYear":"1980","relationship":"same-class"},{"drugId":"oxyphenbutazone","brandName":"oxyphenbutazone","genericName":"oxyphenbutazone","approvalYear":"1960","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"005303","UNII":"TPT3MH65LD","CHEBI":"CHEBI:8768","INN_ID":"2274","RXNORM":"183877","UMLSCUI":"C0650237","ChEMBL_ID":"CHEMBL3833391","KEGG_DRUG":"D07263","DRUGBANK_ID":"DB01129","PUBCHEM_CID":"6433695","SECONDARY_CAS_RN":"60104-29-2","MESH_SUPPLEMENTAL_RECORD_UI":"C073326"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":18,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"M01AA05","allCodes":["M01AA05","M02AA03"]},"biosimilarFilings":[],"recentPublications":[{"date":"2006","pmid":"30000341","title":"Rabeprazole.","journal":""},{"date":"1988","pmid":"3238371","title":"The influence of NSAIDs on morphology of articular cartilage.","journal":"Scandinavian journal of rheumatology. Supplement"},{"date":"1984 Dec","pmid":"6241720","title":"[Comparative studies on the bioavailability of various drug forms of phenylbutazone and clofezone (Perclusone)].","journal":"Die Pharmazie"},{"date":"1984","pmid":"6241218","title":"[Clofezone and oxyphenbutazone excluded from dental use].","journal":"Nihon Shika Ishikai zasshi"},{"date":"1978 Nov-Dec","pmid":"153678","title":"[Animal experiment studies on the effect of intra-articular injections of antiphlogistic-antirheumatic agents on articular cartilage in vivo].","journal":"Zeitschrift fur Rheumatologie"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Clofezone is a small molecule drug in the clofezone class, developed by an unknown entity and currently owned by an unknown entity. Its target and exact mechanism of action are not specified. Clofezone is not FDA-approved for any indications, and its commercial status, half-life, bioavailability, generic manufacturers, and patent status are unknown. As a result, there is limited information available on its safety profile and efficacy. Further research is needed to determine the potential therapeutic applications and risks associated with clofezone.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}