{"id":"clofenotane","rwe":[],"tags":[{"label":"clofenotane","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"P03AB01","category":"atc"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"dicophane","offLabel":[],"synonyms":["dicophane","clofenotane","chlorophenothane","chlorphenothan","clofenotan"],"timeline":[],"approvals":[],"brandName":"Dicophane","ecosystem":[],"mechanism":{"target":"Androgen receptor","modality":"Small Molecule","drugClass":"clofenotane","explanation":"Imagine your body's cells are like locks, and proteins are like keys. Dicophane is a key that fits into a specific lock, allowing it to turn and unlock the cell's activity. This can help to regulate various bodily functions and treat certain medical conditions.","oneSentence":"Dicophane works by binding to and modulating the activity of a specific protein or receptor.","technicalDetail":"Dicophane is a small molecule that interacts with a specific protein or receptor, potentially altering its activity and downstream signaling pathways."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/DDT","title":"DDT","extract":"Dichlorodiphenyltrichloroethane (DDT) is a colorless, tasteless, and almost odorless crystalline chemical compound, an organochloride. Originally developed as an insecticide, it became infamous for its environmental impacts. DDT was first synthesized in 1874 by the Austrian chemist Othmar Zeidler. DDT's insecticidal action was discovered by the Swiss chemist Paul Hermann Müller in 1939. DDT was used in the second half of World War II to limit the spread of the insect-borne diseases malaria and typhus among civilians and troops. Müller was awarded the Nobel Prize in Physiology or Medicine in 1948 \"for his discovery of the high efficiency of DDT as a contact poison against several arthropods\". The World Health Organization's (WHO) anti-malaria campaign of the 1950s and 1960s relied heavily on DDT and the results were promising, though there was a resurgence in developing countries afterwards.","wiki_history":"==History==\nthumb|right|Commercial product concentrate containing 50% DDT, circa 1960s\nthumb|right|Commercial product of [[Ciba-Geigy Néocide (powder box, 50 g) containing 10% DDT, made in France.]]\n\n\nDDT was first synthesized in 1874 by Othmar Zeidler under the supervision of Adolf von Baeyer.<!--Augustin claims that Baeyer synthesized it already in 1872--> It was further described in 1929 in a dissertation by W. Bausch and in two subsequent publications in 1930. The insecticide properties of \"multiple chlorinated aliphatic or fat-aromatic alcohols with at least one trichloromethane group\" were described in a patent in 1934 by Wolfgang von Leuthold. DDT's insecticidal properties were not, however, discovered until 1939 by the Swiss scientist Paul Hermann Müller, who was awarded the 1948 Nobel Prize in Physiology and Medicine for his efforts. Due to the potency of DDT, it was not long before the US War Production Board placed it on military supply lists in 1942 and 1943 and encouraged its production for overseas use. Enthusiasm regarding DDT became obvious through the US government's advertising campaigns of posters depicting US fighting the Axis powers and insects and through media publications celebrating its military uses.\n\nIn 1945, DDT was made available to farmers as an agricultural insecticide Despite concerns emerging in the scientific community, and lack of research, the FDA considered it safe up to 7 parts per million in food. There was a large economic incentive to push DDT into the market and sell it to farmers, governments, and individuals to control diseases and increase food production. The program eliminated the disease in \"North America, Europe, the former Soviet Union\", and dramatically reduced mortality in Sri Lanka and India. The program succeeded in eliminating malaria only in areas with \"high socio-economic status, well-organized healthcare systems, and relatively less intensive or seasonal malaria transmission\".\n\nDDT was less effective in tropi"},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4396","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=clofenotane","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/DDT","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T10:11:45.680057","biosimilars":[],"competitors":[{"drugName":"lindane","drugSlug":"lindane","fdaApproval":"1974-12-19","genericCount":5,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"clofenotane","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"lindane","brandName":"lindane","genericName":"lindane","approvalYear":"1974","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"002996","UNII":"CIW5S16655","CHEBI":"CHEBI:16130","INN_ID":"2202","UMLSCUI":"C0011041","ChEMBL_ID":"CHEMBL416898","KEGG_DRUG":"D07367","DRUGBANK_ID":"DB13424","PDB_CHEM_ID":"6WT","PUBCHEM_CID":"3036"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"P03AB01","allCodes":["P03AB01","P03AB51"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Dicophane, also known as clofenotane, is a small molecule drug of the clofenotane class. Unfortunately, there is limited information available on this compound, and it does not appear to be a well-known or widely used medication. As a result, I am unable to provide a comprehensive summary of its clinical use, safety profile, or commercial status. Further research is needed to determine the target, approved indications, and other key characteristics of dicophane. It is not clear if dicophane is patented or available as a generic medication.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}