{"id":"clofarabine-vp-16-ciclophospahamide","safety":{"commonSideEffects":[{"rate":"30-50%","effect":"Neutropenia"},{"rate":"20-40%","effect":"Thrombocytopenia"},{"rate":"10-30%","effect":"Anemia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Clofarabine VP 16 is a nucleoside analog that inhibits DNA polymerase and ribonucleotide reductase, while cyclophosphamide is an alkylating agent that cross-links DNA, causing cell death. This combination therapy is used to treat various types of cancer.","oneSentence":"Clofarabine VP 16 and cyclophosphamide work by interfering with DNA synthesis and function, leading to cell death in rapidly dividing cancer cells.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T02:31:18.912Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute lymphoblastic leukemia"}]},"trialDetails":[{"nctId":"NCT01385891","phase":"PHASE2, PHASE3","title":"Clove In The Treatment Of Relapsed Or Resistant Acute Leukemia In Children","status":"COMPLETED","sponsor":"Istituto Giannina Gaslini","startDate":"2008-08","conditions":"Acute Leukemia","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Evoltra","Etoposide","Endoxan"],"phase":"phase_2","status":"active","brandName":"Clofarabine VP 16 ciclophospahamide","genericName":"Clofarabine VP 16 ciclophospahamide","companyName":"Istituto Giannina Gaslini","companyId":"istituto-giannina-gaslini","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Clofarabine VP 16 and cyclophosphamide work by interfering with DNA synthesis and function, leading to cell death in rapidly dividing cancer cells. Used for Acute lymphoblastic leukemia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}