{"id":"clocinizine","rwe":[{"pmid":"40841386","year":"2025","title":"Discovery of clocinizine as a potential oral drug against Schistosoma mansoni infection.","finding":"","journal":"Scientific reports","studyType":"Clinical Study"},{"pmid":"18540159","year":"2007","title":"High-performance liquid chromatographic assay for cinnarizine in human plasma.","finding":"","journal":"Acta poloniae pharmaceutica","studyType":"Clinical Study"},{"pmid":"12026119","year":"2002","title":"Determination of active substances in antiallergic and antiphlogistic multicomponent preparations by high performance liquid chromatography (HPLC).","finding":"","journal":"Acta poloniae pharmaceutica","studyType":"Clinical Study"}],"tags":[{"label":"clocinizine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"denoral","offLabel":[],"synonyms":["denoral","clocinizine","chlorcinnarizine","chlorocinnarizine"],"timeline":[],"approvals":[],"brandName":"Denoral","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"clocinizine","explanation":"Imagine your body's cells are like locks, and the key to unlocking them is a specific shape that fits perfectly. Denoral is like a key that tries to fit into one of these locks, but we don't know which lock it's meant for or how well it fits. This interaction is thought to affect the way the body works, but more research is needed to understand the details.","oneSentence":"Denoral is thought to work by interacting with a specific target in the body, although the exact nature of this interaction is not well understood.","technicalDetail":"Denoral is a small molecule that binds to a specific target, although the identity of this target is unknown. The binding of Denoral to its target is thought to modulate the activity of downstream pathways, although the precise mechanisms involved are not well understood."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/688","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CLOCINIZINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:10:57.730414","biosimilars":[],"competitors":[],"genericName":"clocinizine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"004342","UNII":"8HQJ711KH8","CHEBI":"CHEBI:135647","INN_ID":"1599","RXNORM":"402583","UMLSCUI":"C1322002","ChEMBL_ID":"CHEMBL3989706","PUBCHEM_CID":"5375618"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":3,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2025 Aug 21","pmid":"40841386","title":"Discovery of clocinizine as a potential oral drug against Schistosoma mansoni infection.","journal":"Scientific reports"},{"date":"2007 Sep-Oct","pmid":"18540159","title":"High-performance liquid chromatographic assay for cinnarizine in human plasma.","journal":"Acta poloniae pharmaceutica"},{"date":"2002 Jan-Feb","pmid":"12026119","title":"Determination of active substances in antiallergic and antiphlogistic multicomponent preparations by high performance liquid chromatography (HPLC).","journal":"Acta poloniae pharmaceutica"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Denoral is a small molecule medication with the synonyms chlorcinnarizine, chlorocinnarizine, cliocinizine, clocinizina, and clocinizine.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}