{"id":"clobex-shampoo","safety":{"commonSideEffects":[{"rate":null,"effect":"Burning or stinging at application site"},{"rate":null,"effect":"Skin atrophy"},{"rate":null,"effect":"Folliculitis"},{"rate":null,"effect":"Hypertrichosis"},{"rate":null,"effect":"Systemic corticosteroid absorption effects (with prolonged use)"}]},"_chembl":{"chemblId":"CHEMBL2108232","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Clobetasol propionate works by binding to glucocorticoid receptors in skin cells, reducing the production of inflammatory mediators and suppressing T-cell activation. This leads to decreased inflammation, itching, and scaling associated with dermatological conditions. As a Class I (super-potent) corticosteroid, it is among the strongest topical steroids available.","oneSentence":"Clobetasol propionate is a potent topical corticosteroid that suppresses inflammatory and immune responses in the skin.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:42:03.311Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Scalp psoriasis"},{"name":"Seborrheic dermatitis of the scalp"},{"name":"Other inflammatory scalp conditions responsive to topical corticosteroids"}]},"trialDetails":[{"nctId":"NCT00400725","phase":"PHASE3","title":"Maintenance Effect of Clobex Shampoo on Participants With Moderate to Severe Scalp Psoriasis","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2006-09-29","conditions":"Scalp Psoriasis","enrollment":288}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":27,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Clobetasol Propionate 0.05% [weight by weight (W/W)]","Clobetasol Propionate 0.05% (W/W)"],"phase":"phase_3","status":"active","brandName":"Clobex® Shampoo","genericName":"Clobex® Shampoo","companyName":"Galderma R&D","companyId":"galderma-r-d","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Clobetasol propionate is a potent topical corticosteroid that suppresses inflammatory and immune responses in the skin. Used for Scalp psoriasis, Seborrheic dermatitis of the scalp, Other inflammatory scalp conditions responsive to topical corticosteroids.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}