{"id":"clobetasone-butyrate","rwe":[{"pmid":"41815603","year":"2026","title":"Real-World Effectiveness and Safety of Tapinarof 1% Cream in Psoriasis: An Observational Study From Bangladesh.","finding":"","journal":"Cureus","studyType":"Clinical Study"},{"pmid":"41709500","year":"2026","title":"Investigating the Telomerase Downregulatory Potential of Steroidal Drugs Following Pharmacophore-Based Rational; Computational and In Vitro Assessments.","finding":"","journal":"Archiv der Pharmazie","studyType":"Clinical Study"},{"pmid":"39220237","year":"2024","title":"Short-term effect of a moderate-potency topical corticosteroid on epidermal biophysical parameters in patients with mild-to-moderate atopic dermatitis: A randomised controlled study.","finding":"","journal":"Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia","studyType":"Clinical Study"},{"pmid":"39198945","year":"2024","title":"[Simultaneous determination of 61 hormones in water by solid phase extraction-ultra performance liquid chromatography-tandem mass spectrometry].","finding":"","journal":"Se pu = Chinese journal of chromatography","studyType":"Clinical Study"},{"pmid":"37105482","year":"2023","title":"Suspended particulate matter-associated environmental corticosteroids in the Pearl River, China: Occurrence, distribution, and partitioning.","finding":"","journal":"The Science of the total environment","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Glucocorticoid receptor","category":"target"},{"label":"NR3C1","category":"gene"},{"label":"D07AB01","category":"atc"},{"label":"Active","category":"status"},{"label":"Atopic dermatitis","category":"indication"},{"label":"Eczema","category":"indication"},{"label":"Anti-Inflammatory Agents","category":"pharmacology"},{"label":"Glucocorticoids","category":"pharmacology"},{"label":"Hormones","category":"pharmacology"}],"phase":"marketed","safety":{"safetySignals":[{"llr":135.34,"date":"","count":25,"signal":"Skin weeping","source":"DrugCentral FAERS","actionTaken":"Reported 25 times (LLR=135)"},{"llr":126.728,"date":"","count":22,"signal":"Steroid withdrawal syndrome","source":"DrugCentral FAERS","actionTaken":"Reported 22 times (LLR=127)"},{"llr":115.612,"date":"","count":50,"signal":"Skin exfoliation","source":"DrugCentral FAERS","actionTaken":"Reported 50 times (LLR=116)"},{"llr":72.215,"date":"","count":33,"signal":"Eczema","source":"DrugCentral FAERS","actionTaken":"Reported 33 times (LLR=72)"},{"llr":70.211,"date":"","count":24,"signal":"Skin burning sensation","source":"DrugCentral FAERS","actionTaken":"Reported 24 times (LLR=70)"},{"llr":62.568,"date":"","count":35,"signal":"Medication error","source":"DrugCentral FAERS","actionTaken":"Reported 35 times (LLR=63)"},{"llr":60.682,"date":"","count":13,"signal":"Skin wrinkling","source":"DrugCentral FAERS","actionTaken":"Reported 13 times (LLR=61)"},{"llr":54.478,"date":"","count":69,"signal":"Pruritus","source":"DrugCentral FAERS","actionTaken":"Reported 69 times (LLR=54)"},{"llr":51.672,"date":"","count":13,"signal":"Burns second degree","source":"DrugCentral FAERS","actionTaken":"Reported 13 times (LLR=52)"},{"llr":51.446,"date":"","count":13,"signal":"Steroid dependence","source":"DrugCentral FAERS","actionTaken":"Reported 13 times (LLR=51)"},{"llr":49.493,"date":"","count":12,"signal":"Catarrh","source":"DrugCentral FAERS","actionTaken":"Reported 12 times (LLR=49)"},{"llr":49.117,"date":"","count":83,"signal":"Rash","source":"DrugCentral FAERS","actionTaken":"Reported 83 times (LLR=49)"},{"llr":44.978,"date":"","count":16,"signal":"Scab","source":"DrugCentral FAERS","actionTaken":"Reported 16 times (LLR=45)"},{"llr":43.056,"date":"","count":13,"signal":"Hypopnoea","source":"DrugCentral FAERS","actionTaken":"Reported 13 times (LLR=43)"},{"llr":41.697,"date":"","count":12,"signal":"Skin swelling","source":"DrugCentral FAERS","actionTaken":"Reported 12 times (LLR=42)"}],"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=CLOBETASONE BUTYRATE","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:27:12.712598+00:00"},"timeline":{"url":"https://en.wikipedia.org/wiki/Clobetasone Butyrate","method":"deterministic","source":"Wikipedia","rawText":"","confidence":0.8,"sourceType":"wikipedia","retrievedAt":"2026-04-20T00:27:20.020038+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T00:27:17.846155+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CLOBETASONE BUTYRATE","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T00:27:18.147221+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL2308885/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:27:19.679150+00:00"}},"allNames":"eumovate","offLabel":[],"synonyms":["eumovate","kindavate","clobetasone butyrate","21-Chloro-11-dehydrobetamethasone","clobetasone 17-butyrate"],"timeline":[],"aiSummary":"Eumovate (CLOBETASONE BUTYRATE) is a topical glucocorticoid medication that targets the glucocorticoid receptor. It is used to treat atopic dermatitis and eczema. The commercial status of Eumovate is not specified, but it is a small molecule modality. Key safety considerations include potential skin irritation and allergic reactions. As a glucocorticoid, it works by reducing inflammation and immune responses.","approvals":[{"date":"","orphan":false,"company":"","regulator":"PMDA"}],"brandName":"Eumovate","ecosystem":[{"indication":"Atopic dermatitis","otherDrugs":[{"name":"abrocitinib","slug":"abrocitinib","company":"PFIZER Inc"},{"name":"alclometasone dipropionate","slug":"alclometasone-dipropionate","company":""},{"name":"amcinonide","slug":"amcinonide","company":"Astellas"},{"name":"ammonium lactate","slug":"ammonium-lactate","company":"Ranbaxy"}],"globalPrevalence":204050000},{"indication":"Eczema","otherDrugs":[{"name":"dexpanthenol","slug":"dexpanthenol","company":"Hospira"}],"globalPrevalence":null}],"mechanism":{"target":"Glucocorticoid receptor","targets":[{"gene":"NR3C1","source":"DrugCentral","target":"Glucocorticoid receptor","protein":"Glucocorticoid receptor"}],"modality":"Small Molecule","explanation":"","oneSentence":"","technicalDetail":"CLOBETASONE BUTYRATE is a synthetic glucocorticoid that exerts its effects by binding to the glucocorticoid receptor, which then translocates to the nucleus and regulates the expression of anti-inflammatory genes, leading to a decrease in inflammatory cytokines and an increase in anti-inflammatory cytokines."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Clobetasone","title":"Clobetasone","extract":"Clobetasone (INN) is a corticosteroid used in dermatology, for treating such skin inflammation as seen in eczema, psoriasis and other forms of dermatitis, and ophthalmology. Topical clobetasone butyrate has shown minimal suppression of the hypothalamic–pituitary–adrenal axis."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3911","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=CLOBETASONE%20BUTYRATE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CLOBETASONE BUTYRATE","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://en.wikipedia.org/wiki/Clobetasone","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T10:10:46.897132","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T00:27:21.294162+00:00","fieldsConflicting":2,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"hydrocortisone butyrate","drugSlug":"hydrocortisone-butyrate","fdaApproval":"1982-03-31","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"flumetasone","drugSlug":"flumetasone","fdaApproval":"","relationship":"same-class"},{"drugName":"fluorometholone","drugSlug":"fluorometholone","fdaApproval":"1972-01-12","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"desonide","drugSlug":"desonide","fdaApproval":"1972-01-04","patentExpiry":"Aug 13, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"triamcinolone","drugSlug":"triamcinolone","fdaApproval":"1957-12-03","genericCount":9,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"alclometasone dipropionate","drugSlug":"alclometasone-dipropionate","fdaApproval":"1982-12-14","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"hydrocortisone probutate","drugSlug":"hydrocortisone-probutate","fdaApproval":"1997-02-28","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"dexamethasone","drugSlug":"dexamethasone","fdaApproval":"1958-10-30","patentExpiry":"Oct 7, 2036","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"clocortolone pivalate","drugSlug":"clocortolone-pivalate","fdaApproval":"1977-08-22","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"clobetasone butyrate","indications":{"approved":[{"name":"Atopic dermatitis","source":"DrugCentral","snomedId":24079001,"regulator":"FDA","globalPrevalence":204050000,"prevalenceMethod":"ai-extracted","prevalenceSource":"Br J Dermatol, 2023 (PMID:37705227)"},{"name":"Eczema","source":"DrugCentral","snomedId":43116000,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"hydrocortisone-butyrate","brandName":"hydrocortisone butyrate","genericName":"hydrocortisone butyrate","approvalYear":"1982","relationship":"same-class"},{"drugId":"flumetasone","brandName":"flumetasone","genericName":"flumetasone","approvalYear":"","relationship":"same-class"},{"drugId":"fluorometholone","brandName":"fluorometholone","genericName":"fluorometholone","approvalYear":"1972","relationship":"same-class"},{"drugId":"desonide","brandName":"desonide","genericName":"desonide","approvalYear":"1972","relationship":"same-class"},{"drugId":"triamcinolone","brandName":"triamcinolone","genericName":"triamcinolone","approvalYear":"1957","relationship":"same-class"},{"drugId":"alclometasone-dipropionate","brandName":"alclometasone dipropionate","genericName":"alclometasone dipropionate","approvalYear":"1982","relationship":"same-class"},{"drugId":"hydrocortisone-probutate","brandName":"hydrocortisone probutate","genericName":"hydrocortisone probutate","approvalYear":"1997","relationship":"same-class"},{"drugId":"dexamethasone","brandName":"dexamethasone","genericName":"dexamethasone","approvalYear":"1958","relationship":"same-class"},{"drugId":"clocortolone-pivalate","brandName":"clocortolone pivalate","genericName":"clocortolone pivalate","approvalYear":"1977","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT04220554","phase":"NA","title":"Improvement of Psoriasis Patients' Adherence to Topical Drugs","status":"COMPLETED","sponsor":"Odense University Hospital","startDate":"2020-06-19","conditions":["Psoriasis Vulgaris"],"enrollment":103,"completionDate":"2022-06-01"},{"nctId":"NCT03345914","phase":"PHASE3","title":"Study to Investigate the Efficacy and Safety of Dupilumab Administered With Topical Corticosteroids (TCS) in Participants ≥6 to <12 Years With Severe Atopic Dermatitis (AD)","status":"COMPLETED","sponsor":"Regeneron Pharmaceuticals","startDate":"2017-11-17","conditions":["Dermatitis, Atopic"],"enrollment":367,"completionDate":"2019-09-10"},{"nctId":"NCT03461302","phase":"PHASE4","title":"Efficacy of Topical Coal Tar in Children With Atopic Dermatitis","status":"UNKNOWN","sponsor":"Radboud University Medical Center","startDate":"2018-02-01","conditions":["Atopic Dermatitis"],"enrollment":80,"completionDate":"2019-09-01"},{"nctId":"NCT01567995","phase":"PHASE3","title":"Randomised, Double-blind, Placebo-controlled Study of Topical Clobetasone Butyrate 0.05% Cream in Subjects With Eczema for Two Weeks to Evaluate the Efficacy and Safety","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2008-02-28","conditions":["Eczema"],"enrollment":240,"completionDate":"2009-02-10"},{"nctId":"NCT01452997","phase":"PHASE4","title":"Evaluation of Anti-inflammatories in the Reduction of Bite Reactions","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2012-11","conditions":["Mosquito Bite"],"enrollment":40,"completionDate":"2013-04"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"003809","UNII":"8U0H6XI6EO","CHEBI":"CHEBI:31415","INN_ID":"3155","RXNORM":"108074","UMLSCUI":"C0055896","chemblId":"CHEMBL2308885","ChEMBL_ID":"CHEMBL2308885","KEGG_DRUG":"D01273","DRUGBANK_ID":"DB13158","PUBCHEM_CID":"71386","SNOMEDCT_US":"116576003","IUPHAR_LIGAND_ID":"9088","SECONDARY_CAS_RN":"54063-32-0","MESH_SUPPLEMENTAL_RECORD_UI":"C010893"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":98,"therapeuticAreas":["Immunology"],"atcClassification":{"source":"DrugCentral","atcCode":"D07AB01","allCodes":["D07AB01","S01BA09","S01CA11"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026 Feb","pmid":"41815603","title":"Real-World Effectiveness and Safety of Tapinarof 1% Cream in Psoriasis: An Observational Study From Bangladesh.","journal":"Cureus"},{"date":"2026 Feb","pmid":"41709500","title":"Investigating the Telomerase Downregulatory Potential of Steroidal Drugs Following Pharmacophore-Based Rational; Computational and In Vitro Assessments.","journal":"Archiv der Pharmazie"},{"date":"2024","pmid":"39220237","title":"Short-term effect of a moderate-potency topical corticosteroid on epidermal biophysical parameters in patients with mild-to-moderate atopic dermatitis: A randomised controlled study.","journal":"Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia"},{"date":"2024 Sep","pmid":"39198945","title":"[Simultaneous determination of 61 hormones in water by solid phase extraction-ultra performance liquid chromatography-tandem mass spectrometry].","journal":"Se pu = Chinese journal of chromatography"},{"date":"2023 Aug 1","pmid":"37105482","title":"Suspended particulate matter-associated environmental corticosteroids in the Pearl River, China: Occurrence, distribution, and partitioning.","journal":"The Science of the total environment"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"JP","regulator":"PMDA","status":"approved","approval_date":null,"mah":"","brand_name_local":null,"application_number":""},{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T00:27:21.294162+00:00","fieldsConflicting":2,"overallConfidence":0.8},"verificationStatus":"partial","dataCompleteness":{"mechanism":false,"indications":true,"safety":false,"trials":true,"score":2}}