{"id":"clobazam-medium-dose","safety":{"commonSideEffects":[{"rate":"20-30","effect":"Somnolence"},{"rate":"10-20","effect":"Ataxia"},{"rate":"10-15","effect":"Fatigue"},{"rate":"10-15","effect":"Dizziness"},{"rate":"5-10","effect":"Irritability"},{"rate":"5-10","effect":"Insomnia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Clobazam binds to GABA-A receptors on neurons, potentiating the effect of the inhibitory neurotransmitter GABA. This increases chloride ion influx and neuronal hyperpolarization, raising the seizure threshold and reducing the frequency and severity of seizures. It is a 1,5-benzodiazepine with a different structure from classical 1,4-benzodiazepines, which may contribute to its favorable tolerability profile in epilepsy.","oneSentence":"Clobazam is a benzodiazepine that enhances inhibitory GABAergic neurotransmission in the central nervous system to reduce seizure activity.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:06:21.263Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Adjunctive treatment of seizures associated with Lennox-Gastaut syndrome"},{"name":"Adjunctive treatment of focal seizures"}]},"trialDetails":[{"nctId":"NCT00518713","phase":"PHASE3","title":"Clobazam in Patients With Lennox-Gastaut Syndrome","status":"COMPLETED","sponsor":"Lundbeck LLC","startDate":"2007-08","conditions":"Epilepsy, Epilepsy, Generalized, Seizures","enrollment":238}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Onfi™"],"phase":"phase_3","status":"active","brandName":"Clobazam Medium Dose","genericName":"Clobazam Medium Dose","companyName":"Lundbeck LLC","companyId":"lundbeck-llc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Clobazam is a benzodiazepine that enhances inhibitory GABAergic neurotransmission in the central nervous system to reduce seizure activity. Used for Adjunctive treatment of seizures associated with Lennox-Gastaut syndrome, Adjunctive treatment of focal seizures.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}