{"id":"clobazam-high-dose","safety":{"commonSideEffects":[{"rate":null,"effect":"Somnolence"},{"rate":null,"effect":"Ataxia"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Behavioral changes"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Clobazam binds to GABA-A receptors and potentiates the effect of the inhibitory neurotransmitter GABA, increasing chloride channel conductance and neuronal hyperpolarization. This results in reduced neuronal excitability and seizure threshold elevation. The high-dose formulation is being investigated to optimize efficacy in treatment-resistant seizure disorders.","oneSentence":"Clobazam is a benzodiazepine that enhances inhibitory GABAergic neurotransmission in the central nervous system to reduce seizure activity.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:06:21.088Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Seizure disorders / Epilepsy (treatment-resistant or adjunctive therapy)"}]},"trialDetails":[{"nctId":"NCT00518713","phase":"PHASE3","title":"Clobazam in Patients With Lennox-Gastaut Syndrome","status":"COMPLETED","sponsor":"Lundbeck LLC","startDate":"2007-08","conditions":"Epilepsy, Epilepsy, Generalized, Seizures","enrollment":238},{"nctId":"NCT00162981","phase":"PHASE2","title":"Clobazam in Subjects With Lennox-Gastaut Syndrome","status":"COMPLETED","sponsor":"Lundbeck LLC","startDate":"2005-10","conditions":"Epilepsy, Epilepsy, Generalized, Seizures","enrollment":68},{"nctId":"NCT00552526","phase":"PHASE4","title":"Ketogenic Diet vs.Antiepileptic Drug Treatment in Drug Resistant Epilepsy","status":"UNKNOWN","sponsor":"Oslo University Hospital","startDate":"2007-11","conditions":"Epilepsy, Mental Retardation","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":25,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Onfi™"],"phase":"phase_3","status":"active","brandName":"Clobazam High Dose","genericName":"Clobazam High Dose","companyName":"Lundbeck LLC","companyId":"lundbeck-llc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Clobazam is a benzodiazepine that enhances inhibitory GABAergic neurotransmission in the central nervous system to reduce seizure activity. Used for Seizure disorders / Epilepsy (treatment-resistant or adjunctive therapy).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}