{"id":"clinofibrate","rwe":[{"pmid":"41178567","year":"2026","title":"Clinofibrate Disrupts the SNORA80B/YTHDC1-Driven M6A Modification to Suppress Cholesterol Metabolism and Cisplatin Resistance in ESCC.","finding":"","journal":"Advanced science (Weinheim, Baden-Wurttemberg, Germany)","studyType":"Clinical Study"},{"pmid":"29576583","year":"2018","title":"Clinofibrate improved canine lipid metabolism in some but not all breeds.","finding":"","journal":"The Journal of veterinary medical science","studyType":"Clinical Study"},{"pmid":"26012250","year":"2015","title":"Development of a LC-MS/MS method for the estimation of clinofibrate in human urine.","finding":"","journal":"Die Pharmazie","studyType":"Clinical Study"},{"pmid":"23849436","year":"2013","title":"Effect of food on the single-dose pharmacokinetics and tolerability of clinofibrate tablets in Chinese healthy volunteers.","finding":"","journal":"International journal of clinical pharmacology and therapeutics","studyType":"Clinical Study"},{"pmid":"23319135","year":"2013","title":"High-performance liquid chromatographic method for determination of clinofibrate and its application to a pharmacokinetic study in healthy volunteers.","finding":"","journal":"Journal of pharmaceutical and biomedical analysis","studyType":"Clinical Study"}],"tags":[{"label":"clinofibrate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"lipoclin","offLabel":[],"synonyms":["clinofibrate","lipoclin","S-8527","S 8527"],"timeline":[],"approvals":[],"brandName":"Lipoclin","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"clinofibrate","explanation":"Think of Lipoclin like a key that helps unlock the body's natural processes for managing fats. It's believed to help the body use fats more efficiently, but the exact steps it takes to do this are not well understood. This can lead to improved cholesterol levels and overall heart health.","oneSentence":"Lipoclin works by influencing lipid metabolism, although the exact details of its mechanism are unclear.","technicalDetail":"As a clinofibrate, Lipoclin is thought to activate peroxisome proliferator-activated receptors (PPARs), which play a crucial role in regulating lipid metabolism and glucose homeostasis."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Clinofibrate","title":"Clinofibrate","extract":"Clinofibrate is pharmaceutical drug of the fibrate class that is used for managing hyperlipidemia and associated conditions. It is sold and marketed in Japan."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/680","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CLINOFIBRATE","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Clinofibrate","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T10:10:16.664775","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:48:59.435261+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[],"genericName":"clinofibrate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"0374EZJ8CU","CHEBI":"CHEBI:31412","INN_ID":"4421","UMLSCUI":"C0055883","ChEMBL_ID":"CHEMBL1897738","KEGG_DRUG":"D01300","DRUGBANK_ID":"DB09006","PUBCHEM_CID":"2787","MESH_SUPPLEMENTAL_RECORD_UI":"C006231"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":28,"therapeuticAreas":["Metabolic"],"biosimilarFilings":[],"recentPublications":[{"date":"2026 Jan","pmid":"41178567","title":"Clinofibrate Disrupts the SNORA80B/YTHDC1-Driven M6A Modification to Suppress Cholesterol Metabolism and Cisplatin Resistance in ESCC.","journal":"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"},{"date":"2018 Jun 29","pmid":"29576583","title":"Clinofibrate improved canine lipid metabolism in some but not all breeds.","journal":"The Journal of veterinary medical science"},{"date":"2015 Apr","pmid":"26012250","title":"Development of a LC-MS/MS method for the estimation of clinofibrate in human urine.","journal":"Die Pharmazie"},{"date":"2013 Aug","pmid":"23849436","title":"Effect of food on the single-dose pharmacokinetics and tolerability of clinofibrate tablets in Chinese healthy volunteers.","journal":"International journal of clinical pharmacology and therapeutics"},{"date":"2013 Mar 25","pmid":"23319135","title":"High-performance liquid chromatographic method for determination of clinofibrate and its application to a pharmacokinetic study in healthy volunteers.","journal":"Journal of pharmaceutical and biomedical analysis"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lipoclin (CLINOFIBRATE) is a small molecule clinofibrate drug with unknown target and commercial status. It is used to treat unknown indications, but its exact mechanism of action is not well-documented. As a clinofibrate, it is believed to work by modulating lipid metabolism, although specific details are lacking. Further research is needed to fully understand its effects and potential side effects. Its current owner and development status are also unclear.","enrichmentLevel":5,"visitCount":0,"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:48:59.435261+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}