{"id":"clinical-judged-midazolam-administration","safety":{"commonSideEffects":[{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Oversedation"},{"rate":null,"effect":"Paradoxical reaction (agitation)"},{"rate":null,"effect":"Amnesia"}]},"_chembl":{"chemblId":"CHEMBL655","moleculeType":"Small molecule","molecularWeight":"325.77"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Midazolam binds to benzodiazepine receptors on GABA-A channels, increasing chloride ion influx and hyperpolarizing neuronal membranes. This potentiates the inhibitory effects of GABA, resulting in dose-dependent central nervous system depression. Clinical-judged administration refers to individualized dosing based on patient response and clinical assessment rather than fixed protocols.","oneSentence":"Midazolam is a benzodiazepine that enhances inhibitory GABAergic neurotransmission in the central nervous system to produce sedation, anxiolysis, and amnesia.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:43:29.562Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Procedural sedation and anxiolysis"},{"name":"Preoperative anxiolysis"},{"name":"Induction of general anesthesia"},{"name":"Acute agitation and anxiety"}]},"trialDetails":[{"nctId":"NCT00789815","phase":"PHASE4","title":"Bispectral Index-guided Sedation for Flexible Bronchoscopy","status":"COMPLETED","sponsor":"Chang Gung Memorial Hospital","startDate":"2008-04","conditions":"Flexible Bronchoscopy","enrollment":500}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":315,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Clinical-judged midazolam administration","genericName":"Clinical-judged midazolam administration","companyName":"Chang Gung Memorial Hospital","companyId":"chang-gung-memorial-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Midazolam is a benzodiazepine that enhances inhibitory GABAergic neurotransmission in the central nervous system to produce sedation, anxiolysis, and amnesia. Used for Procedural sedation and anxiolysis, Preoperative anxiolysis, Induction of general anesthesia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}