{"id":"clindamycin-phosphate-rld","safety":{"boxedWarning":"Clostridioides difficile-associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including clindamycin, and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C. difficile.","commonSideEffects":["Diarrhea","Nausea","Abdominal pain","Rash","Vaginitis"],"contraindications":["Hypersensitivity to clindamycin or lincomycin","History of regional enteritis, ulcerative colitis, or antibiotic-associated colitis"]},"_chembl":{"chemblId":"CHEMBL3184512","moleculeType":"Small molecule","molecularWeight":"504.97"},"modality":"Small molecule","_dailymed":null,"mechanism":{"target":"50S ribosomal subunit","explanation":"Clindamycin binds to the 23S RNA of the 50S ribosomal subunit, blocking the transpeptidation or translocation reactions, thereby inhibiting early chain elongation. This bacteriostatic action prevents bacterial growth and replication in susceptible organisms.","oneSentence":"Clindamycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing peptide bond formation."},"_scrapedAt":"2026-03-28T04:58:00.403Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"_claudeStub":{"ts":1779123297,"model":"claude-sonnet-4-5-20250929"},"competitors":[{"name":"Metronidazole","brand":"Flagyl","company":null,"rationale":"Alternative antibiotic for anaerobic infections and bacterial vaginosis"},{"name":"Erythromycin","brand":null,"company":null,"rationale":"Macrolide antibiotic for similar gram-positive and anaerobic coverage"},{"name":"Benzoyl peroxide/clindamycin","brand":"BenzaClin","company":null,"rationale":"Combination topical therapy for acne vulgaris"}],"description":"Clindamycin phosphate is a lincosamide antibiotic used to treat serious bacterial infections caused by susceptible anaerobic bacteria and certain gram-positive organisms. It works by inhibiting bacterial protein synthesis. Available in multiple formulations including topical, injectable, and oral forms for various infections.","indications":{"approved":[{"status":"approved","condition":"Bacterial vaginosis","patientPopulation":"Adult women"},{"status":"approved","condition":"Acne vulgaris","patientPopulation":"Adolescents and adults"},{"status":"approved","condition":"Serious anaerobic bacterial infections","patientPopulation":"Adults and pediatrics"},{"status":"approved","condition":"Skin and soft tissue infections","patientPopulation":"Adults and pediatrics"}]},"trialDetails":[{"nctId":"NCT04321070","phase":"PHASE1","title":"Bio-equivalence Study With Clinical Endpoints in the Treatment of Acne Vulgaris","status":"COMPLETED","sponsor":"Sun Pharmaceutical Industries, Inc.","startDate":"2019-09-09","conditions":"Acne Vulgaris","enrollment":550},{"nctId":"NCT04134273","phase":"PHASE1","title":"Bio-equivalence Study With Clinical Endpoints in the Treatment of Acne Vulgaris","status":"COMPLETED","sponsor":"Sun Pharmaceutical Industries, Inc.","startDate":"2019-03-20","conditions":"Acne Vulgaris","enrollment":1260}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Lotion"],"phase":"phase_1","status":"active","brandName":"Clindamycin Phosphate RLD","genericName":"Clindamycin Phosphate RLD","companyName":"Sun Pharmaceutical Industries, Inc.","companyId":"sun-pharmaceutical-industries-inc","firstApprovalDate":"","aiSummary":"Clindamycin Phosphate RLD is a small molecule that inhibits the bacterial 70S ribosome. It is used to treat Acne Vulgaris, as demonstrated in a randomized, double-blind, multiple center placebo controlled study.","enrichmentLevel":3,"visitCount":2,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}