{"id":"clindamycin-gentamicin-irrigation","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation at irrigation site"},{"rate":null,"effect":"Allergic reaction (clindamycin or gentamicin hypersensitivity)"},{"rate":null,"effect":"Nephrotoxicity (gentamicin-related, with systemic absorption)"},{"rate":null,"effect":"Ototoxicity (gentamicin-related, with systemic absorption)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Clindamycin is a lincosamide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, while gentamicin is an aminoglycoside that also inhibits protein synthesis and causes bactericidal effects. When used together as an irrigation solution, they provide broad-spectrum coverage against aerobic and anaerobic bacteria commonly found in surgical and wound infections.","oneSentence":"A combination antibiotic irrigation solution that uses clindamycin and gentamicin to kill bacteria through inhibition of protein synthesis and cell wall disruption.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:42:07.224Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Surgical site infection prophylaxis and treatment via irrigation"},{"name":"Wound irrigation for mixed aerobic and anaerobic bacterial infections"}]},"trialDetails":[{"nctId":"NCT04039750","phase":"PHASE2","title":"Use of Antibiotic Irrigation to Decrease Wound Infections in Pediatric Perforated Appendicitis","status":"ACTIVE_NOT_RECRUITING","sponsor":"Prisma Health-Upstate","startDate":"2019-07-25","conditions":"Perforated Appendicitis","enrollment":200},{"nctId":"NCT06841003","phase":"PHASE3","title":"Laparoscopic Antibiotic Lavage to Prevent Intra-abdominal Abscess Formation in Complicated Appendicitis","status":"NOT_YET_RECRUITING","sponsor":"Spaarne Gasthuis","startDate":"2025-02","conditions":"Complicated Appendicitis, Intra-Abdominal Abscess","enrollment":752},{"nctId":"NCT03945357","phase":"PHASE3","title":"Reducing INfection at the Surgical SitE With Antibiotic Irrigation During Ventral Hernia Repair (RINSE Trial)","status":"COMPLETED","sponsor":"Prisma Health-Upstate","startDate":"2019-05-15","conditions":"Ventral Hernia Repair","enrollment":250},{"nctId":"NCT03476941","phase":"PHASE2","title":"Antibiotic Irrigations for Intra-Abdominal Drains","status":"RECRUITING","sponsor":"Paolo Goffredo","startDate":"2019-04-01","conditions":"Abdominal Abscess","enrollment":50},{"nctId":"NCT03081962","phase":"PHASE3","title":"Effect of a Combination of Bundles on Surgical-site Infection After Elective Colorectal Surgery","status":"UNKNOWN","sponsor":"Hospital General Universitario Elche","startDate":"2017-02-15","conditions":"Surgical Site Infection","enrollment":102},{"nctId":"NCT02479971","phase":"PHASE3","title":"Effect of Peritoneal Lavage With Clindamycin-gentamicin on Laparoscopic Sleeve Gastrectomy","status":"COMPLETED","sponsor":"Hospital General Universitario Elche","startDate":"2014-01","conditions":"Pain","enrollment":60},{"nctId":"NCT02399059","phase":"PHASE3","title":"Effect of Peritoneal Lavage With Clindamycin-Gentamicin Solution & Oncologic Outcome","status":"COMPLETED","sponsor":"Hospital General Universitario Elche","startDate":"2011-01","conditions":"Colorectal Tumors","enrollment":106},{"nctId":"NCT02314806","phase":"PHASE3","title":"Gentamicin Versus Clindamycin Versus Normal Saline Lavage in Axilla","status":"COMPLETED","sponsor":"Hospital General Universitario Elche","startDate":"2013-01","conditions":"Breast Cancer","enrollment":51},{"nctId":"NCT01378832","phase":"PHASE3","title":"Effect of Peritoneal Lavage With Clindamycin-gentamicin Solution on Postoperative Colorectal Cancer Infection in Elective Surgery","status":"COMPLETED","sponsor":"Universidad Miguel Hernandez de Elche","startDate":"2010-01","conditions":"Surgical Site Infection","enrollment":102}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Clindamycin-gentamicin solution"],"phase":"phase_3","status":"active","brandName":"Clindamycin-gentamicin irrigation","genericName":"Clindamycin-gentamicin irrigation","companyName":"Hospital General Universitario Elche","companyId":"hospital-general-universitario-elche","modality":"Small molecule","firstApprovalDate":"","aiSummary":"A combination antibiotic irrigation solution that uses clindamycin and gentamicin to kill bacteria through inhibition of protein synthesis and cell wall disruption. Used for Surgical site infection prophylaxis and treatment via irrigation, Wound irrigation for mixed aerobic and anaerobic bacterial infections.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}