{"id":"clindamycin-and-bpo-5-gel","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation"},{"rate":null,"effect":"Dryness"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Peeling"},{"rate":null,"effect":"Contact dermatitis"}]},"_chembl":{"chemblId":"CHEMBL1200588","moleculeType":"Small molecule","molecularWeight":"461.45"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Clindamycin is a lincosamide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, effectively killing Propionibacterium acnes. Benzoyl peroxide (BPO) is an oxidizing agent that generates reactive oxygen species to destroy bacterial cell walls and also helps reduce comedone formation by normalizing follicular keratinization. The combination provides synergistic antibacterial activity and reduces the risk of antibiotic resistance.","oneSentence":"Clindamycin kills acne-causing bacteria while benzoyl peroxide oxidizes and destroys bacterial cell membranes and reduces sebum production.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:22:31.427Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acne vulgaris"}]},"trialDetails":[{"nctId":"NCT03849885","phase":"PHASE4","title":"Cutibacterium Dermal Colonization: Implications for Total Hip Arthroplasty","status":"UNKNOWN","sponsor":"Colorado Joint Replacement","startDate":"2019-02-02","conditions":"Degenerative Osteoarthritis","enrollment":496},{"nctId":"NCT00441415","phase":"PHASE3","title":"Efficacy and Safety of Fixed Combination Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel in the Treatment of Acne Vulgaris","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2007-02","conditions":"Acne Vulgaris","enrollment":272},{"nctId":"NCT00757523","phase":"PHASE4","title":"Evaluation of the Effectiveness, Safety, and Tolerability of Duac Akne Gel and Epiduo Gel in the Treatment of Facial Acne Vulgaris","status":"COMPLETED","sponsor":"Stiefel, a GSK Company","startDate":"2008-09-10","conditions":"Acne Vulgaris","enrollment":382},{"nctId":"NCT01132443","phase":"PHASE1","title":"W0261-101: A Phase 1, Single Center, Randomized, Open-Label Study to Evaluate the Bioavailability of Clindamycin From Clindamycin 1%-Benzoyl Peroxide 3% Gel, Topical Gel (Clindamycin 1%- Benzoyl Peroxide 5%), and Once Daily Gel (Clindamycin 1%-Benzoyl Peroxide 5%) in Subjects With Acne","status":"COMPLETED","sponsor":"Stiefel, a GSK Company","startDate":"2010-05-06","conditions":"Acne Vulgaris","enrollment":72},{"nctId":"NCT00964366","phase":"PHASE4","title":"Study to Determine and Compare the Tolerance and Irritation Potential of Topical Acne Medications","status":"COMPLETED","sponsor":"Stiefel, a GSK Company","startDate":"2009-07","conditions":"Acne Vulgaris","enrollment":53},{"nctId":"NCT01015638","phase":"PHASE4","title":"Compare the Tolerance of Clindamycin 1% /Benzoyl Peroxide (BPO) 5% Gel to Clindamycin 1.2%/ BPO 2.5% Topical Medications","status":"COMPLETED","sponsor":"Stiefel, a GSK Company","startDate":"2009-08","conditions":"Acne Vulgaris","enrollment":36}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Duac Topical Gel"],"phase":"marketed","status":"active","brandName":"Clindamycin and BPO 5% gel","genericName":"Clindamycin and BPO 5% gel","companyName":"Stiefel, a GSK Company","companyId":"stiefel-a-gsk-company","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Clindamycin kills acne-causing bacteria while benzoyl peroxide oxidizes and destroys bacterial cell membranes and reduces sebum production. Used for Acne vulgaris.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}