{"id":"clinafloxacin","rwe":[{"pmid":"40910393","year":"2025","title":"Transformation of a covalent organic framework from dual pores to single pores and their different properties.","finding":"","journal":"Chemical communications (Cambridge, England)","studyType":"Clinical Study"},{"pmid":"40678879","year":"2025","title":"Chiral Separation and Molecular Simulation of Five Quinolones on a Bonded Amylose[(S)-α-Methylbenzyl Carbamate] Column (CHIRALPAK IH) and the Elucidation of Its Recognition Mechanism.","finding":"","journal":"Chirality","studyType":"Clinical Study"},{"pmid":"40592186","year":"2025","title":"Discovery of thiazolylcyanovinyl benzopyridone acids: Potential new generation antibacterial oxacins?","finding":"","journal":"European journal of medicinal chemistry","studyType":"Clinical Study"},{"pmid":"40495004","year":"2025","title":"Structural insight in understanding the impact of mutation at position 88 and 94 of DNA gyrase A of Mycobacterium tuberculosis in developing resistance against delafloxacin.","finding":"","journal":"Journal of biological physics","studyType":"Clinical Study"},{"pmid":"40180646","year":"2025","title":"5-Repurposed Drug Candidates Identified in Motor Neurons and Muscle Tissues with Amyotrophic Lateral Sclerosis by Network Biology and Machine Learning Based on Gene Expression.","finding":"","journal":"Neuromolecular medicine","studyType":"Clinical Study"}],"tags":[{"label":"clinafloxacin","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Anti-Bacterial Agents","category":"pharmacology"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Antineoplastic Agents","category":"pharmacology"},{"label":"Enzyme Inhibitors","category":"pharmacology"},{"label":"Topoisomerase II Inhibitors","category":"pharmacology"},{"label":"Topoisomerase Inhibitors","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["clinafloxacin"],"offLabel":[],"synonyms":["clinafloxacin"],"timeline":[],"approvals":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"clinafloxacin","explanation":"Imagine your body's cells are like factories that make copies of themselves. Bacteria have their own factories too, and clinafloxacin stops these factories from working by blocking the enzymes that help them make copies of their DNA. This prevents the bacteria from growing and multiplying.","oneSentence":"Clinafloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication and transcription.","technicalDetail":"Clinafloxacin exerts its antibacterial effects by binding to the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV, thereby inhibiting DNA replication and transcription in susceptible bacteria."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/677","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CLINAFLOXACIN","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:06:58.544034","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T11:06:03.009679+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[],"genericName":"clinafloxacin","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"8N86XTF9QD","INN_ID":"6961","UMLSCUI":"C1315753","ChEMBL_ID":"CHEMBL278255","DRUGBANK_ID":"DB14025","PDB_CHEM_ID":" NFX","PUBCHEM_CID":"60063","SNOMEDCT_US":"702747003","IUPHAR_LIGAND_ID":"10793","MESH_SUPPLEMENTAL_RECORD_UI":"C057477"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","halfLife":"5.4 hours","clearance":"4.7 mL/min/kg","bioavailability":"90%","fractionUnbound":"0.96%","volumeOfDistribution":"1.9 L/kg"},"publicationCount":257,"therapeuticAreas":["Infectious Disease"],"biosimilarFilings":[],"recentPublications":[{"date":"2025 Sep 25","pmid":"40910393","title":"Transformation of a covalent organic framework from dual pores to single pores and their different properties.","journal":"Chemical communications (Cambridge, England)"},{"date":"2025 Aug","pmid":"40678879","title":"Chiral Separation and Molecular Simulation of Five Quinolones on a Bonded Amylose[(S)-α-Methylbenzyl Carbamate] Column (CHIRALPAK IH) and the Elucidation of Its Recognition Mechanism.","journal":"Chirality"},{"date":"2025 Nov 5","pmid":"40592186","title":"Discovery of thiazolylcyanovinyl benzopyridone acids: Potential new generation antibacterial oxacins?","journal":"European journal of medicinal chemistry"},{"date":"2025 Jun 10","pmid":"40495004","title":"Structural insight in understanding the impact of mutation at position 88 and 94 of DNA gyrase A of Mycobacterium tuberculosis in developing resistance against delafloxacin.","journal":"Journal of biological physics"},{"date":"2025 Apr 3","pmid":"40180646","title":"5-Repurposed Drug Candidates Identified in Motor Neurons and Muscle Tissues with Amyotrophic Lateral Sclerosis by Network Biology and Machine Learning Based on Gene Expression.","journal":"Neuromolecular medicine"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"CLINAFLOXACIN","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Clinafloxacin is a small molecule antibiotic belonging to the fluoroquinolone class. It is currently owned by a pharmaceutical company, but its original developer is unknown. Clinafloxacin has not been approved by the FDA for any indications, and its commercial status is unclear. The drug has a half-life of 5.4 hours and a bioavailability of 90%. Further information on its development and approval status is needed.","enrichmentLevel":5,"visitCount":0,"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T11:06:03.009679+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}