{"id":"climbazole","rwe":[{"pmid":"41903726","year":"2026","title":"Physicochemical Processes as an Alternative to Biological Removal of Azoles from Wastewater.","finding":"","journal":"Environmental research","studyType":"Clinical Study"},{"pmid":"41809629","year":"2026","title":"Soil accumulation and plant uptake of pharmaceutical active compounds and related metabolites from irrigation water in fennel (Foeniculum vulgare Mill.).","finding":"","journal":"Frontiers in plant science","studyType":"Clinical Study"},{"pmid":"41769372","year":"2026","title":"Rapid ecotoxicity and genotoxicity assessment using Macropodus ocellatus cells.","finding":"","journal":"Toxicological research","studyType":"Clinical Study"},{"pmid":"41617885","year":"2026","title":"Seasonal and spatial dynamics of organic micropollutants in a Mediterranean river: implications for environmental risk assessment.","finding":"","journal":"Environmental geochemistry and health","studyType":"Clinical Study"},{"pmid":"41304553","year":"2025","title":"Occurrence, Distribution and Risk Assessment of Biocides in Chao Lake and Its Tributaries.","finding":"","journal":"Toxics","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Cytochrome P450 3A4","category":"target"},{"label":"CYP3A4","category":"gene"},{"label":"Active","category":"status"},{"label":"Seborrheic dermatitis","category":"indication"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"climbazol","offLabel":[],"synonyms":["climbazole","climbazol","Bay-e-6975"],"timeline":[],"approvals":[],"brandName":"Climbazol","ecosystem":[{"indication":"Seborrheic dermatitis","otherDrugs":[{"name":"alclometasone dipropionate","slug":"alclometasone-dipropionate","company":""},{"name":"allantoin","slug":"allantoin","company":""},{"name":"amcinonide","slug":"amcinonide","company":"Astellas"},{"name":"ammonia","slug":"ammonia","company":""}],"globalPrevalence":null}],"mechanism":{"target":"Cytochrome P450 3A4","targets":[{"gene":"CYP3A4","source":"DrugCentral","target":"Cytochrome P450 3A4","protein":"Cytochrome P450 3A4"}],"modality":"Small Molecule","explanation":"Think of your body like a factory with many machines working together. Cytochrome P450 3A4 is like a key machine that helps break down certain medicines. Climbazol is like a special tool that blocks this machine, which can affect how your body processes these medicines.","oneSentence":"Climbazol works by blocking the action of an enzyme called Cytochrome P450 3A4.","technicalDetail":"Climbazol acts as a competitive inhibitor of Cytochrome P450 3A4, a member of the cytochrome P450 enzyme family involved in the metabolism of various drugs."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/5064","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CLIMBAZOLE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:10:01.206998","biosimilars":[],"competitors":[{"drugName":"abiraterone acetate","drugSlug":"abiraterone-acetate","fdaApproval":"2011-04-28","patentExpiry":"May 20, 2034","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"aliskiren","drugSlug":"aliskiren","fdaApproval":"2007-03-05","patentExpiry":"Feb 19, 2026","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"alprazolam","drugSlug":"alprazolam","fdaApproval":"1981-10-16","genericCount":24,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"amiodarone","drugSlug":"amiodarone","fdaApproval":"1985-12-24","patentExpiry":"Mar 13, 2029","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"amprenavir","drugSlug":"amprenavir","fdaApproval":"1999-04-15","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"aprepitant","drugSlug":"aprepitant","fdaApproval":"2003-03-27","patentExpiry":"Sep 26, 2027","patentStatus":"Patent 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RQH","PUBCHEM_CID":"37907","SNOMEDCT_US":"711318001","MESH_SUPPLEMENTAL_RECORD_UI":"C108286"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":126,"therapeuticAreas":["Metabolic"],"biosimilarFilings":[],"recentPublications":[{"date":"2026 Mar 26","pmid":"41903726","title":"Physicochemical Processes as an Alternative to Biological Removal of Azoles from Wastewater.","journal":"Environmental research"},{"date":"2026","pmid":"41809629","title":"Soil accumulation and plant uptake of pharmaceutical active compounds and related metabolites from irrigation water in fennel (Foeniculum vulgare Mill.).","journal":"Frontiers in plant science"},{"date":"2026 Mar","pmid":"41769372","title":"Rapid ecotoxicity and genotoxicity assessment using Macropodus ocellatus cells.","journal":"Toxicological research"},{"date":"2026 Jan 30","pmid":"41617885","title":"Seasonal and spatial dynamics of organic micropollutants in a Mediterranean river: 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Its commercial status is unknown, and it is not FDA approved. Climbazol works by inhibiting the activity of Cytochrome P450 3A4, a key enzyme involved in the metabolism of various drugs. The exact mechanism of action in treating Seborrheic dermatitis is not well understood. Further research is needed to determine its efficacy and safety.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}