{"id":"clemizole","rwe":[{"pmid":"41741668","year":"2026","title":"Clemizole inhibits CrtN-driven staphyloxanthin biosynthesis in Staphylococcus aureus to enhance host immune clearance.","finding":"","journal":"Communications biology","studyType":"Clinical Study"},{"pmid":"41603740","year":"2026","title":"Repositioning Antihistamine for Cancer Therapy: Clemizole as a Template for the Design of Liver Tissue-Targeting Epigenetic-Modifying Agents.","finding":"","journal":"Journal of medicinal chemistry","studyType":"Clinical Study"},{"pmid":"41371876","year":"2025","title":"Expanding the toolkit: An update on the evolution of new therapies for Lennox-Gastaut Syndrome.","finding":"","journal":"Seminars in pediatric neurology","studyType":"Clinical Study"},{"pmid":"38703217","year":"2024","title":"Effect of Clemizole on Alpha-Synuclein-Preformed Fibrils-Induced Parkinson's Disease Pathology: A Pharmacological Investigation.","finding":"","journal":"Neuromolecular medicine","studyType":"Clinical Study"},{"pmid":"38279926","year":"2025","title":"Structural and accessibility studies highlight the differential binding of clemizole to TRPC5 and TRPC6.","finding":"","journal":"Journal of biomolecular structure & dynamics","studyType":"Clinical Study"}],"tags":[{"label":"clemizole","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Histamine H4 receptor","category":"target"},{"label":"HRH4","category":"gene"},{"label":"TRPC5","category":"gene"},{"label":"TRPC6","category":"gene"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"lergopenin","offLabel":[],"synonyms":["clemizole","lergopenin","clemizole hydrochloride","clemizole HCl"],"timeline":[],"approvals":[],"brandName":"Lergopenin","ecosystem":[],"mechanism":{"target":"Short transient receptor potential channel 4, Histamine H4 receptor, Short transient receptor potential channel 3","targets":[{"gene":"HRH4","source":"DrugCentral","target":"Histamine H4 receptor","protein":"Histamine H4 receptor"},{"gene":"TRPC5","source":"DrugCentral","target":"Short transient receptor potential channel 5","protein":"Short transient receptor potential channel 5"},{"gene":"TRPC6","source":"DrugCentral","target":"Short transient receptor potential channel 6","protein":"Short transient receptor potential channel 6"},{"gene":"TRPC4","source":"DrugCentral","target":"Short transient receptor potential channel 4","protein":"Short transient receptor potential channel 4"},{"gene":"TRPC3","source":"DrugCentral","target":"Short transient receptor potential channel 3","protein":"Short transient receptor potential channel 3"}],"modality":"Small Molecule","drugClass":"clemizole","explanation":"Imagine your immune system is like a fire alarm that goes off when it detects something wrong. The histamine H4 receptor is like a switch that helps turn on the alarm. Clemizole blocks this switch, which can help reduce inflammation and other symptoms associated with immune system overactivity.","oneSentence":"Clemizole works by binding to the histamine H4 receptor, which is involved in the regulation of immune responses and inflammation.","technicalDetail":"Clemizole acts as a selective antagonist of the histamine H4 receptor, a G-protein coupled receptor involved in the regulation of immune cell function and inflammation."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/672","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=CLEMIZOLE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CLEMIZOLE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:09:38.372558","biosimilars":[],"competitors":[{"drugName":"amitriptyline","drugSlug":"amitriptyline","fdaApproval":"1961-04-07","genericCount":33,"patentStatus":"Off-patent — generic 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Efficacy and Safety Study of Clemizole HCl in Patients With Lennox-Gastaut Syndrome","status":"RECRUITING","sponsor":"Epygenix","startDate":"2025-04-09","conditions":["Lennox Gastaut Syndrome"],"enrollment":260,"completionDate":"2029-11-01"},{"nctId":"NCT04462770","phase":"PHASE3","title":"A Study of EPX-100 (Clemizole Hydrochloride) in Participants With Dravet Syndrome","status":"RECRUITING","sponsor":"Epygenix","startDate":"2020-09-15","conditions":["Dravet Syndrome"],"enrollment":150,"completionDate":"2029-05-01"},{"nctId":"NCT04069689","phase":"PHASE1","title":"Study of Safety and Pharmacokinetics of Oral Doses of EPX-100 in Healthy Subjects.","status":"COMPLETED","sponsor":"Epygenix","startDate":"2019-08-29","conditions":["Dravet Syndrome"],"enrollment":24,"completionDate":"2019-11-27"},{"nctId":"NCT00945880","phase":"PHASE1","title":"Safety and Tolerability Study of Clemizole Hydrochloride to Treat Hepatitis C in Subjects Who Are 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