{"id":"clebopride","rwe":[{"pmid":"40703482","year":"2025","title":"[Multidisciplinary approach for a patient with morbid obesity and psychological issues led from the pharmacy office].","finding":"","journal":"Farmaceuticos comunitarios","studyType":"Clinical Study"},{"pmid":"40128365","year":"2025","title":"Clebopride stimulates 5-HT(4)-serotonin receptors in the human atrium.","finding":"","journal":"Naunyn-Schmiedeberg's archives of pharmacology","studyType":"Clinical Study"},{"pmid":"37868913","year":"2023","title":"Clebopride-Associated Movement Disorders.","finding":"","journal":"Movement disorders clinical practice","studyType":"Clinical Study"},{"pmid":"36581089","year":"2023","title":"Efficacy and Safety of Drugs for Gastroparesis: Systematic Review and Network Meta-analysis.","finding":"","journal":"Gastroenterology","studyType":"Clinical Study"},{"pmid":"31145322","year":"2019","title":"Acute dystonic reaction induced by a single dose of clebopride: A case report.","finding":"","journal":"Medicine","studyType":"Clinical Study"}],"tags":[{"label":"clebopride","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"D(4) dopamine receptor","category":"target"},{"label":"DRD4","category":"gene"},{"label":"DRD3","category":"gene"},{"label":"DRD2","category":"gene"},{"label":"A03FA06","category":"atc"},{"label":"Active","category":"status"},{"label":"Antiemetics","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Gastrointestinal Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"}],"phase":"phase_2","safety":{"safetySignals":[{"llr":84.933,"date":"","count":12,"signal":"Mixed liver injury","source":"DrugCentral FAERS","actionTaken":"Reported 12 times (LLR=85)"}],"commonSideEffects":[{"effect":"Mixed liver injury","drugRate":"LLR 85","severity":"common"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["clebopride","clebopride maleate"],"offLabel":[],"synonyms":["clebopride","clebopride maleate"],"timeline":[],"approvals":[],"ecosystem":[],"mechanism":{"target":"D(4) dopamine receptor, Acetylcholinesterase, D(2) dopamine receptor","targets":[{"gene":"DRD4","source":"DrugCentral","target":"D(4) dopamine receptor","protein":"D(4) dopamine receptor"},{"gene":"DRD3","source":"DrugCentral","target":"D(3) dopamine receptor","protein":"D(3) dopamine receptor"},{"gene":"DRD2","source":"DrugCentral","target":"D(2) dopamine receptor","protein":"D(2) dopamine receptor"},{"gene":"KCNH2","source":"DrugCentral","target":"Potassium voltage-gated channel subfamily H member 2","protein":"Potassium voltage-gated channel subfamily H member 2"},{"gene":"ACHE","source":"DrugCentral","target":"Acetylcholinesterase","protein":"Acetylcholinesterase"}],"modality":"Small Molecule","drugClass":"clebopride","explanation":"Imagine your digestive system as a highway with cars moving at different speeds. 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Its exact mechanism of action is not specified in the provided information.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":true,"trials":false,"score":2}}