{"id":"cle","safety":{"commonSideEffects":[{"rate":null,"effect":"Dyskinesia"},{"rate":null,"effect":"Motor fluctuations"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Orthostatic hypotension"}]},"_chembl":null,"_dailymed":{"setId":"4dde8b03-84e2-5ec7-e063-6394a90a6910","title":"OXY DEEP PORE ACNE CLEANSING PADS (SALICYLIC ACID) FOR SOLUTION [THE MENTHOLATUM COMPANY]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Levodopa is converted to dopamine in the brain to replace depleted neurotransmitter levels in Parkinson's disease. Carbidopa is a decarboxylase inhibitor that prevents premature conversion of levodopa to dopamine in the periphery, allowing more levodopa to reach the brain. The extended-release formulation provides sustained drug delivery to reduce motor fluctuations.","oneSentence":"CLE is a combination formulation of carbidopa and levodopa in an extended-release delivery system designed to provide more consistent dopamine replacement in the brain for Parkinson's disease management.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:06:18.112Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Parkinson's disease"}]},"trialDetails":[{"nctId":"NCT05531565","phase":"PHASE2, PHASE3","title":"A 2-Part Study to Learn Whether Litifilimab (BIIB059) Injections Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus","status":"RECRUITING","sponsor":"Biogen","startDate":"2022-09-13","conditions":"Subacute Cutaneous Lupus Erythematosus, Chronic Cutaneous Lupus Erythematosus","enrollment":450},{"nctId":"NCT06980805","phase":"PHASE2","title":"A Study to Assess the Safety, Tolerability, and 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Lymphadenopathies","enrollment":469},{"nctId":"NCT07040241","phase":"NA","title":"Confocal Laser Endomicroscopy Assisted Ultrasound Guided Pleural Biopsy","status":"NOT_YET_RECRUITING","sponsor":"China-Japan Friendship Hospital","startDate":"2025-07-01","conditions":"Pleural Effusion Disorder","enrollment":260},{"nctId":"NCT07004946","phase":"","title":"Diagnostic Value of Confocal Laser Endomicroscopy (CelTouch) for Peripheral Lung Lesions","status":"RECRUITING","sponsor":"Guangzhou Medical University","startDate":"2025-05-31","conditions":"Peripheral Pulmonary Lesion","enrollment":286},{"nctId":"NCT05805020","phase":"NA","title":"Cellvizio to Evaluate Margins in Crohn's Ileal Disease","status":"RECRUITING","sponsor":"Centre Hospitalier Universitaire, Amiens","startDate":"2022-03-03","conditions":"Crohn Disease, Resection Margins, Recurrence","enrollment":41},{"nctId":"NCT06965244","phase":"PHASE3","title":"Lenalidomide vs Methotrexate in Difficult-to-treat Cutaneous Lupus 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of Cutaneous Lupus Erythematosus","status":"RECRUITING","sponsor":"University of Pennsylvania","startDate":"2006-12","conditions":"Cutaneous Lupus Erythematosus (CLE)","enrollment":700},{"nctId":"NCT06867978","phase":"PHASE1","title":"Multi-center Study on CCeLL-In Vivo's Clinical Efficacy for Intraoperative Brain Tumor Diagnosis.","status":"NOT_YET_RECRUITING","sponsor":"VPIX Medical","startDate":"2025-06-01","conditions":"Frozen Sections, Indocyanine Green, Brain Tumor","enrollment":100},{"nctId":"NCT06792838","phase":"NA","title":"Endomicroscopic Evaluation of Food-induced Gastrointestinal Mucosal Alteration","status":"NOT_YET_RECRUITING","sponsor":"Cook Children's Health Care System","startDate":"2025-03","conditions":"Irritable Bowel Syndrome, Food Allergy","enrollment":200},{"nctId":"NCT04731129","phase":"","title":"Mini Invasive Endomicroscopy of the Pleura for Malignancies Diagnosis","status":"COMPLETED","sponsor":"University of 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(AMC-UvA)","startDate":"2024-10-08","conditions":"Lung Neoplasm, Peripheral Lung Parenchyma Tumor, Lung Cancer","enrollment":25},{"nctId":"NCT05314478","phase":"NA","title":"Headgear Accessory for Exercise-Induced Laryngeal Obstruction Studies","status":"COMPLETED","sponsor":"Liverpool University Hospitals NHS Foundation Trust","startDate":"2022-03-24","conditions":"Exercise-Induced Laryngeal Obstruction","enrollment":30},{"nctId":"NCT02755714","phase":"PHASE1, PHASE2","title":"Atrovent in Exercise Induced Laryngeal Obstruction (EILO)","status":"COMPLETED","sponsor":"Haukeland University Hospital","startDate":"2016-06-22","conditions":"Exercise Induced Laryngeal Obstruction (EILO)","enrollment":20},{"nctId":"NCT06505304","phase":"","title":"AI-enabled Endoscopic Prediction of Post-operative Recurrence in Crohn's Disease","status":"RECRUITING","sponsor":"University College Cork","startDate":"2024-05-01","conditions":"Crohn Disease","enrollment":225},{"nctId":"NCT05056610","phase":"NA","title":"Confocal Laser Endomicroscopy to Determine Influence of Food Antigens on Mucosal Integrity","status":"COMPLETED","sponsor":"University of Erlangen-Nürnberg Medical School","startDate":"2021-05-01","conditions":"Irritable Bowel Syndrome, Food Sensitivity, Healthy Controls","enrollment":17},{"nctId":"NCT05097872","phase":"NA","title":"ConfocAl endomicroSCopy bAsed Diet Trial in IBS","status":"RECRUITING","sponsor":"Universitaire Ziekenhuizen KU Leuven","startDate":"2021-10-19","conditions":"Irritable Bowel Syndrome","enrollment":65},{"nctId":"NCT05666154","phase":"NA","title":"Confocal Laser Endomicroscopy Based Diet in Functional Dyspepsia","status":"RECRUITING","sponsor":"Universitaire Ziekenhuizen KU Leuven","startDate":"2021-12-05","conditions":"Functional Dyspepsia","enrollment":65},{"nctId":"NCT06480084","phase":"NA","title":"Prevalence of EILO Among Children With Asthma","status":"NOT_YET_RECRUITING","sponsor":"Medisch Spectrum Twente","startDate":"2024-08-01","conditions":"Exercise Induced Laryngeal Obstruction, Asthma in Children, Exercise-Induced Bronchospasm","enrollment":200},{"nctId":"NCT05695456","phase":"PHASE1, PHASE2","title":"Targeted Elimination Diet in EoE Patients Following Identification of Trigger Nutrients Using Confocal Laser Endomicroscopy","status":"RECRUITING","sponsor":"Universitaire Ziekenhuizen KU Leuven","startDate":"2022-02-16","conditions":"Eosinophilic Esophagitis","enrollment":25},{"nctId":"NCT06457087","phase":"","title":"Optical Biopsy for Peripheral Pulmonary Lesions","status":"NOT_YET_RECRUITING","sponsor":"Shanghai Chest Hospital","startDate":"2024-06","conditions":"Peripheral Pulmonary Lesions","enrollment":150},{"nctId":"NCT06152445","phase":"NA","title":"Wheat Bread Study: Comparison of the Tolerance of Different Wheat Breads","status":"RECRUITING","sponsor":"University of Hohenheim","startDate":"2023-04-19","conditions":"Non-celiac Gluten Sensitivity, Wheat Hypersensitivity","enrollment":64},{"nctId":"NCT06413004","phase":"NA","title":"Brachyspira and Intestinal Allergy-like Immune Reactions in Patients With Irritable Bowel Syndrome (IBS)","status":"RECRUITING","sponsor":"Magnus Simrén","startDate":"2022-08-03","conditions":"Irritable Bowel Syndrome, Food Sensitivity","enrollment":200},{"nctId":"NCT06411106","phase":"NA","title":"Deep Phenotyping of Cutaneous Lupus Erythematosus","status":"RECRUITING","sponsor":"Centre for Human Drug Research, Netherlands","startDate":"2024-06","conditions":"Cutaneous Lupus Erythematosus","enrollment":40},{"nctId":"NCT06389448","phase":"NA","title":"Comparison of pCLE and EB in Gastric Lesion Diagnosis","status":"RECRUITING","sponsor":"Huazhong University of Science and Technology","startDate":"2024-04-11","conditions":"Low Grade Intraepithelial Neoplasia, High Grade Intraepithelial Neoplasia, Early Gastric Cancer","enrollment":366},{"nctId":"NCT04809623","phase":"PHASE1","title":"Study of Edecesertib in Participants With Cutaneous Lupus Erythematosus (CLE)","status":"TERMINATED","sponsor":"Gilead Sciences","startDate":"2021-09-01","conditions":"Cutaneous Lupus Erythematosus","enrollment":3},{"nctId":"NCT06289803","phase":"NA","title":"The Application of Probe Confocal Laser Endomicroscopy in Pancreatic Tumor Surgery","status":"UNKNOWN","sponsor":"Fudan University","startDate":"2023-09-01","conditions":"Pancreatic Cancer, Diagnosis, Pancreatoduodenectomy","enrollment":200},{"nctId":"NCT04647708","phase":"PHASE1","title":"Study of M5049 in CLE and SLE Participants","status":"COMPLETED","sponsor":"Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany","startDate":"2020-12-16","conditions":"Systemic Lupus Erythematosus, Cutaneous Lupus Erythematosus","enrollment":25},{"nctId":"NCT06056882","phase":"","title":"Simultaneous CLE Guided Crybiopsy in Patients 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