{"id":"clarithromycin-syrup-125-mg","safety":{"commonSideEffects":[{"rate":"3-5%","effect":"Diarrhea"},{"rate":"2-4%","effect":"Nausea"},{"rate":"1-3%","effect":"Abdominal pain"},{"rate":"1-2%","effect":"Vomiting"},{"rate":"1-2%","effect":"Headache"},{"rate":null,"effect":"QT prolongation"},{"rate":null,"effect":"Hepatotoxicity"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Clarithromycin is a macrolide antibiotic that binds irreversibly to the bacterial 50S ribosomal subunit, blocking translocation of peptides and halting protein synthesis. This bacteriostatic action prevents bacterial replication and allows the immune system to clear the infection. It is effective against a broad spectrum of gram-positive and some gram-negative bacteria, as well as atypical organisms.","oneSentence":"Clarithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing peptide bond formation and bacterial growth.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:06:17.100Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bacterial respiratory tract infections (community-acquired pneumonia, acute bronchitis)"},{"name":"Otitis media"},{"name":"Sinusitis"},{"name":"Skin and soft tissue infections"},{"name":"Helicobacter pylori eradication (as part of combination therapy)"}]},"trialDetails":[{"nctId":"NCT04016051","phase":"PHASE3","title":"Acceptance of Clarithromycin in a Straw Compared to Syrup in Children With Upper Respiratory Tract Infections","status":"COMPLETED","sponsor":"Grünenthal GmbH","startDate":"2004-09-22","conditions":"Otitis Media, Tonsillitis, Pharyngitis","enrollment":265}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Klacid Syrup® Forte 250 mg/5mL"],"phase":"phase_3","status":"active","brandName":"Clarithromycin Syrup (125 mg)","genericName":"Clarithromycin Syrup (125 mg)","companyName":"Grünenthal GmbH","companyId":"gr-nenthal-gmbh","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Clarithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing peptide bond formation and bacterial growth. Used for Bacterial respiratory tract infections (community-acquired pneumonia, acute bronchitis), Otitis media, Sinusitis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}