{"id":"clarithromycin-dst-250-mg","safety":{"commonSideEffects":[{"rate":"10-30","effect":"Gastrointestinal disturbances (nausea, diarrhea, abdominal pain)"},{"rate":"2-5","effect":"Headache"},{"rate":"1-3","effect":"Taste disturbance"},{"rate":"rare","effect":"QT prolongation"},{"rate":"rare","effect":"Hepatotoxicity"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Clarithromycin binds irreversibly to the bacterial 50S ribosomal subunit, blocking peptide translocation and inhibiting protein synthesis. This bacteriostatic action prevents bacterial growth and replication. The drug is effective against a broad spectrum of gram-positive and some gram-negative bacteria, as well as atypical organisms.","oneSentence":"Clarithromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:45:11.921Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bacterial respiratory tract infections"},{"name":"Helicobacter pylori eradication (as part of combination therapy)"},{"name":"Atypical mycobacterial infections"}]},"trialDetails":[{"nctId":"NCT04016051","phase":"PHASE3","title":"Acceptance of Clarithromycin in a Straw Compared to Syrup in Children With Upper Respiratory Tract Infections","status":"COMPLETED","sponsor":"Grünenthal GmbH","startDate":"2004-09-22","conditions":"Otitis Media, Tonsillitis, Pharyngitis","enrollment":265}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Clarithromycin DST (250 mg)","genericName":"Clarithromycin DST (250 mg)","companyName":"Grünenthal GmbH","companyId":"gr-nenthal-gmbh","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Clarithromycin DST is a small molecule medication used to treat various upper respiratory tract infections, including Otitis Media, Tonsillitis, Pharyngitis, and Bronchitis. It is available in different dosages, including 250 mg, which is being studied in clinical trials for its effectiveness and patient adherence.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}