{"id":"clarithromycin-dst-187-5-mg","safety":{"commonSideEffects":[{"rate":"10-30","effect":"Gastrointestinal disturbance (nausea, diarrhea, abdominal pain)"},{"rate":"5-10","effect":"Headache"},{"rate":"5-10","effect":"Taste disturbance"},{"rate":"1-5","effect":"QT prolongation"},{"rate":"1-3","effect":"Hepatotoxicity"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Clarithromycin binds irreversibly to the bacterial 50S ribosomal subunit, blocking peptide translocation and inhibiting protein synthesis. This bacteriostatic action prevents bacterial growth and replication. The 187.5 mg formulation suggests a pediatric or modified-release preparation of this established macrolide antibiotic.","oneSentence":"Clarithromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:06:16.100Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bacterial respiratory tract infections"},{"name":"Helicobacter pylori eradication (as part of combination therapy)"},{"name":"Mycobacterial infections (MAC prophylaxis/treatment)"}]},"trialDetails":[{"nctId":"NCT04016051","phase":"PHASE3","title":"Acceptance of Clarithromycin in a Straw Compared to Syrup in Children With Upper Respiratory Tract Infections","status":"COMPLETED","sponsor":"Grünenthal GmbH","startDate":"2004-09-22","conditions":"Otitis Media, Tonsillitis, Pharyngitis","enrollment":265}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Clarithromycin DST (187.5 mg)","genericName":"Clarithromycin DST (187.5 mg)","companyName":"Grünenthal GmbH","companyId":"gr-nenthal-gmbh","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Clarithromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. Used for Bacterial respiratory tract infections, Helicobacter pylori eradication (as part of combination therapy), Mycobacterial infections (MAC prophylaxis/treatment).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}