{"id":"clarithromycin-dst-125-mg","safety":{"commonSideEffects":[{"rate":"10-30","effect":"Gastrointestinal disturbance (nausea, diarrhea, abdominal pain)"},{"rate":"2-5","effect":"Headache"},{"rate":"1-3","effect":"Taste disturbance"},{"rate":"rare","effect":"QT prolongation"},{"rate":"rare","effect":"Hepatotoxicity"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Clarithromycin binds irreversibly to the bacterial 50S ribosomal subunit, blocking peptide translocation and inhibiting protein synthesis. This bacteriostatic action prevents bacterial growth and replication. The drug is effective against a broad spectrum of gram-positive and some gram-negative bacteria, as well as atypical organisms.","oneSentence":"Clarithromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:45:06.999Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bacterial respiratory tract infections"},{"name":"Helicobacter pylori eradication (as part of combination therapy)"},{"name":"Atypical pneumonia (Mycoplasma, Chlamydia)"}]},"trialDetails":[{"nctId":"NCT04016051","phase":"PHASE3","title":"Acceptance of Clarithromycin in a Straw Compared to Syrup in Children With Upper Respiratory Tract Infections","status":"COMPLETED","sponsor":"Grünenthal GmbH","startDate":"2004-09-22","conditions":"Otitis Media, Tonsillitis, Pharyngitis","enrollment":265}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Clarithromycin DST (125 mg)","genericName":"Clarithromycin DST (125 mg)","companyName":"Grünenthal GmbH","companyId":"gr-nenthal-gmbh","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Clarithromycin DST (125 mg) is a small molecule used to treat various upper respiratory tract infections, including Otitis Media, Tonsillitis, Pharyngitis, and Bronchitis. It is administered in a novel application form, specifically designed for children, to improve treatment satisfaction and adherence.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}