{"id":"cl-sys-sensitive-fluoride-toothpaste","safety":{"commonSideEffects":[{"rate":"unknown","effect":"Tooth sensitivity"}]},"_chembl":{"chemblId":"CHEMBL1362","moleculeType":"Small molecule","molecularWeight":"19.00"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"The fluoride ions in ClōSYS Sensitive Fluoride Toothpaste help to remineralize tooth enamel, making teeth more resistant to acid attacks from plaque bacteria and sugars in the mouth. This can help to prevent tooth decay and strengthen tooth enamel, making teeth less sensitive and more resistant to wear and tear.","oneSentence":"ClōSYS Sensitive Fluoride Toothpaste works by releasing fluoride ions to help prevent tooth decay and strengthen tooth enamel.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T03:08:11.399Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of tooth decay and strengthening of tooth enamel"}]},"trialDetails":[{"nctId":"NCT05258721","phase":"PHASE2","title":"Efficacy of ClōSYS® Sensitive Fluoride Toothpaste and ClōSYS® Sensitive Rinse Regimen on MGI, PI and BOP","status":"COMPLETED","sponsor":"Rowpar Pharmaceuticals, Inc.","startDate":"2021-07-06","conditions":"Gingivitis, Periodontitis","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"ClōSYS® Sensitive Fluoride Toothpaste","genericName":"ClōSYS® Sensitive Fluoride Toothpaste","companyName":"Rowpar Pharmaceuticals, Inc.","companyId":"rowpar-pharmaceuticals-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"ClōSYS Sensitive Fluoride Toothpaste works by releasing fluoride ions to help prevent tooth decay and strengthen tooth enamel. Used for Prevention of tooth decay and strengthening of tooth enamel.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}