{"id":"citric-acid-based-mouthwash","safety":{"commonSideEffects":[{"rate":null,"effect":"Tooth sensitivity"},{"rate":null,"effect":"Oral irritation"},{"rate":null,"effect":"Enamel erosion (with prolonged use)"}]},"_chembl":{"chemblId":"CHEMBL1261","moleculeType":"Small molecule","molecularWeight":"192.12"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Citric acid is a weak organic acid that reduces the pH of the oral cavity, creating conditions unfavorable for cariogenic and pathogenic bacteria. The acidic environment helps dissolve biofilm and plaque while potentially enhancing antimicrobial activity. This mechanism supports oral hygiene and may help prevent dental caries and gingivitis.","oneSentence":"Citric acid in mouthwash works by lowering oral pH to create an acidic environment that inhibits bacterial growth and reduces plaque formation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:30:06.650Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Oral hygiene and plaque control"},{"name":"Caries prevention"},{"name":"Gingivitis management"}]},"trialDetails":[{"nctId":"NCT03578900","phase":"PHASE4","title":"Quality of Life and Sjögren Syndrome","status":"COMPLETED","sponsor":"Grupo de Investigação em Bioquímica e Biologia Oral","startDate":"2013-01-01","conditions":"Xerostomia, Hyposalivation, Quality of Life","enrollment":289},{"nctId":"NCT01115049","phase":"PHASE4","title":"Hexetidine and Chlorobutanol for Lesions Due to Prostheses","status":"COMPLETED","sponsor":"Federico II University","startDate":"2010-02","conditions":"Oral Mucositis","enrollment":44}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Citric Acid based Mouthwash","genericName":"Citric Acid based Mouthwash","companyName":"Grupo de Investigação em Bioquímica e Biologia Oral","companyId":"grupo-de-investiga-o-em-bioqu-mica-e-biologia-oral","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Citric acid in mouthwash works by lowering oral pH to create an acidic environment that inhibits bacterial growth and reduces plaque formation. Used for Oral hygiene and plaque control, Caries prevention, Gingivitis management.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}