{"id":"citiolone","rwe":[{"pmid":"24156819","year":"2013","title":"Oxyhalogen-sulfur chemistry: kinetics and mechanism of oxidation of N-acetyl homocysteine thiolactone by acidified bromate and aqueous bromine.","finding":"","journal":"The journal of physical chemistry. A","studyType":"Clinical Study"},{"pmid":"9827694","year":"1998","title":"Macrophages and antioxidant status in the NOD mouse pancreas.","finding":"","journal":"Journal of cellular biochemistry","studyType":"Clinical Study"},{"pmid":"9301047","year":"1997","title":"Thiols and selenium: protective effect on human skin fibroblasts exposed to UVA radiation.","finding":"","journal":"Journal of photochemistry and photobiology. B, Biology","studyType":"Clinical Study"},{"pmid":"9252880","year":"1997","title":"Recurrent fixed drug eruption caused by citiolone.","finding":"","journal":"Journal of investigational allergology & clinical immunology","studyType":"Clinical Study"},{"pmid":"8770936","year":"1996","title":"Diabetes-mediated decreases in ovarian superoxide dismutase activity are related to blood-follicle barrier and ovulation defects.","finding":"","journal":"Endocrinology","studyType":"Clinical Study"}],"tags":[{"label":"citiolone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"A05BA04","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"citiolase","offLabel":[],"synonyms":["cythiolone","citiolone","citiolase","thioxidrene","N-Acetylhomocysteine thiolactone"],"timeline":[],"approvals":[],"brandName":"Citiolase","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"citiolone","explanation":"Imagine citiolone as a key that fits into a lock on a cell. When it binds to this lock, it triggers a series of events that ultimately lead to the desired therapeutic outcome. This process can help to modulate various cellular pathways and restore balance to the body.","oneSentence":"Citiolone is thought to work by interacting with a specific cellular target to produce a therapeutic effect.","technicalDetail":"Citiolone's exact mechanism of action is unknown, but it is believed to involve the modulation of cellular signaling pathways, potentially through the interaction with a specific protein or receptor."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/665","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CITIOLONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:03:34.840765","biosimilars":[],"competitors":[{"drugName":"glycyrrhizic acid","drugSlug":"glycyrrhizic-acid","fdaApproval":"","relationship":"same-class"}],"genericName":"citiolone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"glycyrrhizic-acid","brandName":"glycyrrhizic acid","genericName":"glycyrrhizic acid","approvalYear":"","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"006956","UNII":"70JKL15MUH","CHEBI":"CHEBI:94403","INN_ID":"2677","RXNORM":"21171","UMLSCUI":"C0055804","ChEMBL_ID":"CHEMBL2104457","KEGG_DRUG":"D07105","DRUGBANK_ID":"DB13442","PUBCHEM_CID":"14520","MESH_SUPPLEMENTAL_RECORD_UI":"C000486"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":27,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"A05BA04","allCodes":["A05BA04"]},"biosimilarFilings":[],"recentPublications":[{"date":"2013 Dec 12","pmid":"24156819","title":"Oxyhalogen-sulfur chemistry: kinetics and mechanism of oxidation of N-acetyl homocysteine thiolactone by acidified bromate and aqueous bromine.","journal":"The journal of physical chemistry. A"},{"date":"1998 Dec 15","pmid":"9827694","title":"Macrophages and antioxidant status in the NOD mouse pancreas.","journal":"Journal of cellular biochemistry"},{"date":"1997 Aug","pmid":"9301047","title":"Thiols and selenium: protective effect on human skin fibroblasts exposed to UVA radiation.","journal":"Journal of photochemistry and photobiology. B, Biology"},{"date":"1997 May-Jun","pmid":"9252880","title":"Recurrent fixed drug eruption caused by citiolone.","journal":"Journal of investigational allergology & clinical immunology"},{"date":"1996 Jul","pmid":"8770936","title":"Diabetes-mediated decreases in ovarian superoxide dismutase activity are related to blood-follicle barrier and ovulation defects.","journal":"Endocrinology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Citiolase, also known as citiolone, is a small molecule drug of the citiolone class. Its exact target and mechanism of action are unknown, but it is being developed for potential therapeutic applications. The commercial status of citiolone is unclear, and it has not been approved by the FDA for any indications. Further research is needed to determine its safety and efficacy. As a result, there is limited information available about its pharmacokinetic properties.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}