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Oxaliplatin is a third-generation platinum agent with a different spectrum of activity and toxicity profile compared to cisplatin, particularly regarding neurotoxicity patterns.","oneSentence":"Cisplatin and oxaliplatin are platinum-based chemotherapy agents that bind to DNA and form cross-links, preventing DNA replication and triggering cancer cell death.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:06:03.328Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Colorectal cancer (oxaliplatin component)"},{"name":"Ovarian cancer (cisplatin component)"},{"name":"Testicular cancer (cisplatin component)"},{"name":"Gastric cancer (oxaliplatin component)"}]},"trialDetails":[{"nctId":"NCT04847063","phase":"PHASE1","title":"Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal 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