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This dual mechanism of action makes cisplatin combined with topotecan a potent chemotherapeutic agent.","oneSentence":"Cisplatin works by crosslinking DNA, thereby inhibiting DNA replication and transcription, while topotecan inhibits topoisomerase I, preventing DNA repair and replication.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T02:30:52.418Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Small cell lung cancer"},{"name":"Ovarian cancer"}]},"_fixedFields":["pubmed(452)"],"trialDetails":[{"nctId":"NCT02114229","phase":"PHASE2","title":"Phase 2 Study of Alisertib Therapy for Rhabdoid Tumors","status":"ACTIVE_NOT_RECRUITING","sponsor":"St. Jude Children's Research Hospital","startDate":"2014-05-14","conditions":"Malignant Rhabdoid Tumor, Atypical Teratoid Rhabdoid Tumor","enrollment":125},{"nctId":"NCT06942039","phase":"EARLY_PHASE1","title":"Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post 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