{"id":"cisapride","rwe":[{"pmid":"41133197","year":"2025","title":"Assessment of clinically relevant drugs as feline P-glycoprotein substrates.","finding":"","journal":"Frontiers in veterinary science","studyType":"Clinical Study"},{"pmid":"40692085","year":"2025","title":"Computationally informed point of departure evaluation for proarrhythmic cardiotoxicity assessment using 3D engineered cardiac microtissues from human iPSC-derived cardiomyocytes.","finding":"","journal":"Toxicological sciences : an official journal of the Society of Toxicology","studyType":"Clinical Study"},{"pmid":"40683363","year":"2025","title":"Legacy hERG study data in contemporary integrated risk assessments - mitigating the risk of protocol and positive control article differences.","finding":"","journal":"Journal of pharmacological and toxicological methods","studyType":"Clinical Study"},{"pmid":"40604869","year":"2025","title":"Assessment of the effect of prokinetic drugs on transit time and 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Agents","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"},{"label":"Serotonin Agents","category":"pharmacology"},{"label":"Serotonin Receptor Agonists","category":"pharmacology"}],"phase":"marketed","safety":{"safetySignals":[{"llr":1108.559,"date":"","count":216,"signal":"Electrocardiogram QT prolonged","source":"DrugCentral FAERS","actionTaken":"Reported 216 times (LLR=1109)"}],"drugInteractions":[{"url":"/drug/high-risk-qt-prolonging-agents","drug":"High Risk QT Prolonging Agents","action":"Avoid combination","effect":"Highest Risk QTc-Prolonging Agents may enhance the QTc-prolonging effect of other Highest Risk QTc-Prolonging Agents","source":"DrugCentral","drugSlug":"high-risk-qt-prolonging-agents"},{"url":"/drug/strong-cyp3a4-inhibitors","drug":"Strong CYP3A4 Inhibitors","action":"Avoid combination","effect":"QT prolongation have been reported in patients taking cisapride with other drugs that inhibit 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Clarithromycin","source":"DrugCentral","drugSlug":"clarithromycin"},{"url":"/drug/clomipramine","drug":"clomipramine","action":"Avoid combination","effect":"May interact with Clomipramine","source":"DrugCentral","drugSlug":"clomipramine"},{"url":"/drug/darunavir","drug":"darunavir","action":"Avoid combination","effect":"May interact with Darunavir","source":"DrugCentral","drugSlug":"darunavir"},{"url":"/drug/delavirdine","drug":"delavirdine","action":"Avoid combination","effect":"May interact with Delavirdine Mesylate","source":"DrugCentral","drugSlug":"delavirdine"},{"url":"/drug/desipramine","drug":"desipramine","action":"Avoid combination","effect":"May interact with Desipramine","source":"DrugCentral","drugSlug":"desipramine"},{"url":"/drug/dichlorphenamide","drug":"dichlorphenamide","action":"Avoid combination","effect":"May interact with Dichlorphenamide","source":"DrugCentral","drugSlug":"dichlorphenamide"},{"url":"/drug/diltiazem","drug":"diltiazem","action":"Avoid combination","effect":"May interact with Diltiazem","source":"DrugCentral","drugSlug":"diltiazem"},{"url":"/drug/disopyramide","drug":"disopyramide","action":"Avoid combination","effect":"May interact with Disopyramide","source":"DrugCentral","drugSlug":"disopyramide"},{"url":"/drug/doxepin","drug":"doxepin","action":"Avoid combination","effect":"May interact with Doxepin","source":"DrugCentral","drugSlug":"doxepin"},{"url":"/drug/efavirenz","drug":"efavirenz","action":"Avoid combination","effect":"May interact with Efavirenz","source":"DrugCentral","drugSlug":"efavirenz"},{"url":"/drug/encainide","drug":"encainide","action":"Avoid combination","effect":"May interact with Encainide","source":"DrugCentral","drugSlug":"encainide"},{"url":"/drug/erythromycin","drug":"erythromycin","action":"Avoid combination","effect":"May interact with Erythromycin","source":"DrugCentral","drugSlug":"erythromycin"},{"url":"/drug/ethacrynic-acid","drug":"ethacrynic acid","action":"Avoid combination","effect":"May interact with Ethacrynic Acid","source":"DrugCentral","drugSlug":"ethacrynic-acid"}],"commonSideEffects":[],"contraindications":["Angina pectoris","Bradycardia","Chronic heart failure","Congenital long QT syndrome","Disease of liver","Disorder of electrolytes","Epilepsy","Gastrointestinal hemorrhage","Hypocalcemia","Hypokalemia","Hypomagnesemia","Hypophosphatemia","Kidney disease","Mechanical ileus","Myocardial ischemia","Prolonged QT interval","Respiratory insufficiency","Severe dehydration","Ventricular arrhythmia"]},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=CISAPRIDE","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:25:22.572988+00:00"},"timeline":{"url":"https://en.wikipedia.org/wiki/Cisapride","method":"deterministic","source":"Wikipedia","rawText":"","confidence":0.8,"sourceType":"wikipedia","retrievedAt":"2026-04-20T00:25:29.659345+00:00"},"aiSummary":{"url":"","method":"ai_extraction","source":"AI Strategic Summary","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"ai_extraction","retrievedAt":"2026-04-20T00:25:37.543484+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada 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BASE/ML"},{"date":"1997-11-07","type":"positive","source":"FDA Orange Book","milestone":"Propulsid Quicksolv approved — EQ 20MG BASE"}],"aiSummary":"Cisapride (Alimix) is a marketed drug primarily indicated for gastroesophageal reflux disease, enhancing gastrointestinal motility through increased acetylcholine release in the enteric nervous system. Its key competitive advantage lies in its mechanism of action, which differentiates it from metoclopramide, a same-class competitor with a patent expiry in November 2038. The primary risk to Alimix is the key composition patent expiry in 2028, which could lead to generic competition and potential revenue erosion.","approvals":[{"date":"1993-07-29","orphan":false,"company":"","regulator":"FDA"}],"brandName":"Alimix","ecosystem":[{"indication":"Gastroesophageal reflux disease","otherDrugs":[{"name":"algeldrate","slug":"algeldrate","company":"Sanofi Aventis Us"},{"name":"almasilate","slug":"almasilate","company":""},{"name":"cimetidine","slug":"cimetidine","company":""},{"name":"dexlansoprazole","slug":"dexlansoprazole","company":"Takeda Pharms Usa"}],"globalPrevalence":null}],"mechanism":{"target":"5-hydroxytryptamine receptor 2A","novelty":"Follow-on","targets":[{"gene":"HTR2A","source":"DrugCentral","target":"5-hydroxytryptamine receptor 2A","protein":"5-hydroxytryptamine receptor 2A"},{"gene":"KCNH2","source":"DrugCentral","target":"Potassium voltage-gated channel subfamily H member 2","protein":"Potassium voltage-gated channel subfamily H member 2"},{"gene":"HTR4","source":"DrugCentral","target":"5-hydroxytryptamine receptor 4","protein":"5-hydroxytryptamine receptor 4"},{"gene":"ADRA1D","source":"DrugCentral","target":"Alpha-1D adrenergic receptor","protein":"Alpha-1D adrenergic receptor"},{"gene":"DRD3","source":"DrugCentral","target":"D(3) dopamine receptor","protein":"D(3) dopamine receptor"},{"gene":"CYP2D6","source":"DrugCentral","target":"Cytochrome P450 2D6","protein":"Cytochrome P450 2D6"},{"gene":"HTR2B","source":"DrugCentral","target":"5-hydroxytryptamine receptor 2B","protein":"5-hydroxytryptamine receptor 2B"},{"gene":"ADRA2C","source":"DrugCentral","target":"Alpha-2C adrenergic receptor","protein":"Alpha-2C adrenergic receptor"},{"gene":"HTR3A","source":"DrugCentral","target":"Serotonin 3 (5-HT3) receptor","protein":"5-hydroxytryptamine receptor 3A"},{"gene":"HTR3B","source":"DrugCentral","target":"Serotonin 3 (5-HT3) receptor","protein":"5-hydroxytryptamine receptor 3B"}],"modality":"Small Molecule","drugClass":"High Risk QT Prolonging Agents","explanation":"","oneSentence":"","technicalDetail":"Cisapride acts as a selective 5-HT4 receptor agonist, which increases the release of acetylcholine from the myenteric plexus, leading to increased gastrointestinal motility and enhanced gastric emptying."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Cisapride","title":"Cisapride","extract":"Cisapride is a gastroprokinetic agent, a drug that increases motility in the upper gastrointestinal tract. It acts directly as a serotonin 5-HT4 receptor agonist and indirectly as a parasympathomimetic. Stimulation of the serotonin receptors increases acetylcholine release in the enteric nervous system. It has been sold under the trade names Prepulsid (Janssen-Ortho) and Propulsid (in the United States). It was discovered by Janssen Pharmaceuticals in 1980. In many countries, it has been either withdrawn from the market or had its indications limited due to incidence of serious cardiac side-effects. Propulsid was linked to children's deaths."},"commercial":{"launchDate":"1993","_launchSource":"DrugCentral (FDA 1993-07-29, )"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/660","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=CISAPRIDE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CISAPRIDE","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://en.wikipedia.org/wiki/Cisapride","fields":["history","overview"],"source":"Wikipedia"},{"id":5,"url":"https://www.fda.gov/drugs/drug-approvals-and-databases/orange-book-data-files","fields":["patents","exclusivity","genericManufacturers"],"source":"FDA Orange 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