{"id":"ciprofloxacin-hcl-and-hydrocortisone","safety":{"commonSideEffects":[{"rate":null,"effect":"Ear irritation or discomfort"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Taste perversion"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is a fixed-dose combination designed for otic (ear) use. Ciprofloxacin is a fluoroquinolone antibiotic that prevents bacterial DNA replication by inhibiting essential enzymes. Hydrocortisone is a corticosteroid that suppresses local inflammation and immune-mediated tissue damage, reducing pain and swelling associated with ear infections.","oneSentence":"Ciprofloxacin kills bacteria by inhibiting DNA gyrase and topoisomerase IV, while hydrocortisone reduces inflammation and immune response in the ear.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:45:01.027Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute otitis externa (swimmer's ear)"},{"name":"Otitis media with effusion or tympanostomy tubes"}]},"trialDetails":[{"nctId":"NCT00332163","phase":"PHASE2","title":"Skin Toxicity Treatment in Metastatic Colorectal Cancer (mCRC) Patients Receiving Panitumumab + Irinotecan-based Therapy","status":"COMPLETED","sponsor":"Amgen","startDate":"2006-04","conditions":"Metastatic Colorectal Cancer, Skin Rash, Skin Toxicities","enrollment":95},{"nctId":"NCT00980876","phase":"PHASE3","title":"A Comparative Study Between Two Formulations of the Ciprofloxacin Hydrochloride + Hydrocortisone Otic Suspension","status":"COMPLETED","sponsor":"Farmoquimica S.A.","startDate":"2012-04","conditions":"Otitis Externa","enrollment":224}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Otociriax"],"phase":"phase_3","status":"active","brandName":"Ciprofloxacin HCl and Hydrocortisone","genericName":"Ciprofloxacin HCl and Hydrocortisone","companyName":"Farmoquimica S.A.","companyId":"farmoquimica-s-a","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ciprofloxacin kills bacteria by inhibiting DNA gyrase and topoisomerase IV, while hydrocortisone reduces inflammation and immune response in the ear. Used for Acute otitis externa (swimmer's ear), Otitis media with effusion or tympanostomy tubes.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}