{"id":"cinnoxicam","rwe":[{"pmid":"33016059","year":"2020","title":"L-carnitine as primary or adjuvant treatment in infertile patients with varicocele. A systematic review.","finding":"","journal":"Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica","studyType":"Clinical Study"},{"pmid":"22543677","year":"2012","title":"Reduction in sperm aneuploidy levels in severe oligoasthenoteratospermic patients after medical therapy: a preliminary report.","finding":"","journal":"Asian journal of andrology","studyType":"Clinical Study"},{"pmid":"17592742","year":"2007","title":"Unusual coordinating behavior by three non-steroidal anti-inflammatory drugs from the oxicam family towards copper(II). Synthesis, X-ray structure for copper(II)-isoxicam, -meloxicam and -cinnoxicam-derivative complexes, and cytotoxic activity for a copper(II)-piroxicam complex.","finding":"","journal":"Journal of inorganic biochemistry","studyType":"Clinical Study"},{"pmid":"16491265","year":"2006","title":"Male idiopathic oligoasthenoteratozoospermia.","finding":"","journal":"Asian journal of andrology","studyType":"Clinical Study"},{"pmid":"15292108","year":"2004","title":"Cinnoxicam and L-carnitine/acetyl-L-carnitine treatment for idiopathic and varicocele-associated oligoasthenospermia.","finding":"","journal":"Journal of andrology","studyType":"Clinical Study"}],"tags":[{"label":"Nonsteroidal Anti-inflammatory Drug","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Analgesics","category":"pharmacology"},{"label":"Analgesics, Non-Narcotic","category":"pharmacology"},{"label":"Anti-Inflammatory Agents","category":"pharmacology"},{"label":"Anti-Inflammatory Agents, Non-Steroidal","category":"pharmacology"},{"label":"Antirheumatic Agents","category":"pharmacology"},{"label":"Cyclooxygenase Inhibitors","category":"pharmacology"},{"label":"Enzyme Inhibitors","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"sinartrol","offLabel":[],"synonyms":["sinartrol","cinnoxicam","piroxicam cinnamate"],"timeline":[],"approvals":[],"brandName":"Sinartrol","ecosystem":[],"mechanism":{"moaClass":"Cyclooxygenase Inhibitors","modality":"Small Molecule","drugClass":"Nonsteroidal Anti-inflammatory Drug","explanation":"Think of prostaglandins like messengers that tell your body to feel pain and become inflamed. When Sinartrol blocks these messengers, it helps to reduce pain and inflammation. This is similar to how aspirin works, but Sinartrol is a different type of medication.","oneSentence":"Sinartrol works by blocking the production of prostaglandins, which are hormone-like substances that cause pain and inflammation.","technicalDetail":"Sinartrol is a selective COX-2 inhibitor, which means it preferentially blocks the COX-2 enzyme, a key player in the production of prostaglandins. By inhibiting COX-2, Sinartrol reduces the production of prostaglandins, leading to decreased inflammation and pain."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/655","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=cinnoxicam","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:02:28.716118","biosimilars":[],"competitors":[],"genericName":"cinnoxicam","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"MMSL":"1529","NDDF":"002389","UNII":"7E8Q32N75N","CHEBI":"CHEBI:135749","VANDF":"4018626","INN_ID":"3713","RXNORM":"33787","UMLSCUI":"C0071149","ChEMBL_ID":"CHEMBL2106889","KEGG_DRUG":"D05512","DRUGBANK_ID":"DB15883","PUBCHEM_CID":"6436090","SNOMEDCT_US":"27754002","MESH_DESCRIPTOR_UI":"D010894","MESH_SUPPLEMENTAL_RECORD_UI":"C057291"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":17,"therapeuticAreas":["Pain"],"biosimilarFilings":[],"recentPublications":[{"date":"2020 Oct 2","pmid":"33016059","title":"L-carnitine as primary or adjuvant treatment in infertile patients with varicocele. A systematic review.","journal":"Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica"},{"date":"2012 Jul","pmid":"22543677","title":"Reduction in sperm aneuploidy levels in severe oligoasthenoteratospermic patients after medical therapy: a preliminary report.","journal":"Asian journal of andrology"},{"date":"2007 Aug","pmid":"17592742","title":"Unusual coordinating behavior by three non-steroidal anti-inflammatory drugs from the oxicam family towards copper(II). Synthesis, X-ray structure for copper(II)-isoxicam, -meloxicam and -cinnoxicam-derivative complexes, and cytotoxic activity for a copper(II)-piroxicam complex.","journal":"Journal of inorganic biochemistry"},{"date":"2006 Mar","pmid":"16491265","title":"Male idiopathic oligoasthenoteratozoospermia.","journal":"Asian journal of andrology"},{"date":"2004 Sep-Oct","pmid":"15292108","title":"Cinnoxicam and L-carnitine/acetyl-L-carnitine treatment for idiopathic and varicocele-associated oligoasthenospermia.","journal":"Journal of andrology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Sinartrol is a small molecule with the synonyms PIROXICAM CINNAMATE, PIROXICAM CINNAMIC ACID ESTER, and others. Its exact mechanism of action is not specified in the provided information.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}