{"id":"cinmetacin","rwe":[{"pmid":"7858726","year":"1994","title":"Gas chromatographic-electron-impact chemical ionization mass spectrometric identification of cinmetacin and its metabolites in human urine.","finding":"","journal":"Journal of chromatography. B, Biomedical applications","studyType":"Clinical Study"},{"pmid":"3259136","year":"1988","title":"Plasma pharmacokinetics of cinmetacin following oral administration in healthy volunteers.","finding":"","journal":"Arzneimittel-Forschung","studyType":"Clinical Study"},{"pmid":"2880970","year":"1986","title":"On the binding of cinmetacin and indomethacin to human serum albumin.","finding":"","journal":"The Journal of pharmacy and pharmacology","studyType":"Clinical Study"},{"pmid":"7004981","year":"1980","title":"[Clinical study of the efficacy of and tolerance for a new nonsteroidal anti-inflammatory agent, cinmetacin].","finding":"","journal":"Giornale di clinica medica","studyType":"Clinical Study"},{"pmid":"301808","year":"1977","title":"[Brief note on the use of cinmetacin in the treatment of rheumatic diseases].","finding":"","journal":"La Clinica terapeutica","studyType":"Clinical Study"}],"tags":[{"label":"cinmetacin","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"cindomet","offLabel":[],"synonyms":["cinmetacin","cindomet","cinmethacin","indolacin"],"timeline":[],"approvals":[],"brandName":"Cindomet","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"cinmetacin","explanation":"Imagine your body has a factory that produces chemicals called prostaglandins, which are like messengers that tell your brain that you're in pain or inflamed. Cinmetacin is like a factory worker who stops the production of these messengers, reducing the pain and inflammation. This helps to relieve symptoms of conditions like arthritis or other inflammatory diseases.","oneSentence":"Cinmetacin works by blocking the production of prostaglandins, hormone-like substances that cause pain and inflammation.","technicalDetail":"Cinmetacin is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits the enzyme cyclooxygenase (COX), which is responsible for the production of prostaglandins from arachidonic acid."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3711","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CINMETACIN","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:03:23.808888","biosimilars":[],"competitors":[],"genericName":"cinmetacin","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"3ZLI4719J9","CHEBI":"CHEBI:135478","INN_ID":"2881","UMLSCUI":"C2699223","ChEMBL_ID":"CHEMBL2104135","PUBCHEM_CID":"6433761","SECONDARY_CAS_RN":"881743-37-9","MESH_SUPPLEMENTAL_RECORD_UI":"C013887"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":7,"therapeuticAreas":["Pain"],"biosimilarFilings":[],"recentPublications":[{"date":"1994 Oct 3","pmid":"7858726","title":"Gas chromatographic-electron-impact chemical ionization mass spectrometric identification of cinmetacin and its metabolites in human urine.","journal":"Journal of chromatography. B, Biomedical applications"},{"date":"1988 Jan","pmid":"3259136","title":"Plasma pharmacokinetics of cinmetacin following oral administration in healthy volunteers.","journal":"Arzneimittel-Forschung"},{"date":"1986 Dec","pmid":"2880970","title":"On the binding of cinmetacin and indomethacin to human serum albumin.","journal":"The Journal of pharmacy and pharmacology"},{"date":"1980 Jul","pmid":"7004981","title":"[Clinical study of the efficacy of and tolerance for a new nonsteroidal anti-inflammatory agent, cinmetacin].","journal":"Giornale di clinica medica"},{"date":"1977 Jun 30","pmid":"301808","title":"[Brief note on the use of cinmetacin in the treatment of rheumatic diseases].","journal":"La Clinica terapeutica"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cindomet is a small molecule with synonyms including Cindomet, Cinmetacin, Cinmetacina, Cinmetacine, and Indolacine.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}