{"id":"cinalukast","rwe":[{"pmid":"38895744","year":"2024","title":"Azologs of the Fatty Acid Mimetic Drug Cinalukast Enable Light-Induced PPARα Activation.","finding":"","journal":"ChemMedChem","studyType":"Clinical Study"},{"pmid":"35751129","year":"2023","title":"In-silico discovery of inhibitors against human papillomavirus E1 protein.","finding":"","journal":"Journal of biomolecular structure & dynamics","studyType":"Clinical Study"},{"pmid":"32179525","year":"2020","title":"MK-571, a Cysteinyl Leukotriene Receptor 1 Antagonist, Inhibits Hepatitis C Virus Replication.","finding":"","journal":"Antimicrobial agents and chemotherapy","studyType":"Clinical Study"},{"pmid":"31141287","year":"2019","title":"Computer-Assisted Selective Optimization of Side-Activities-from Cinalukast to a PPARα Modulator.","finding":"","journal":"ChemMedChem","studyType":"Clinical Study"},{"pmid":"23859232","year":"2013","title":"A review on leukotrienes and their receptors with reference to asthma.","finding":"","journal":"The Journal of asthma : official journal of the Association for the Care of Asthma","studyType":"Clinical Study"}],"tags":[{"label":"cinalukast","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Cysteinyl leukotriene receptor 1","category":"target"},{"label":"CYSLTR1","category":"gene"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"ro 24-5913","offLabel":[],"synonyms":["cinalukast","Ro 24-5913"],"timeline":[],"aiSummary":"Ro 24-5913 is a small molecule with the synonyms CINALUKAST, CINALUKAST, RO 24-5913, RO-24-5913, and RO-245913.","approvals":[],"brandName":"Ro 24-5913","ecosystem":[],"mechanism":{"target":"Cysteinyl leukotriene receptor 1, Cysteinyl leukotriene receptor 1","targets":[{"gene":"CYSLTR1","source":"DrugCentral","target":"Cysteinyl leukotriene receptor 1","protein":"Cysteinyl leukotriene receptor 1"}],"modality":"Small Molecule","drugClass":"cinalukast","explanation":"Imagine your body's immune system is like a fire alarm. When it senses an intruder, it sounds the alarm and sends out chemical signals to fight the invader. CINALUKAST helps to turn off the fire alarm by blocking the receptor that receives these chemical signals, reducing the body's inflammatory response.","oneSentence":"CINALUKAST works by blocking the cysteinyl leukotriene receptor 1, which plays a key role in the body's inflammatory response.","technicalDetail":"CINALUKAST acts as a competitive antagonist at the cysteinyl leukotriene receptor 1 (CysLT1R), inhibiting the binding of cysteinyl leukotrienes (CysLTs) and thereby reducing the downstream effects of these pro-inflammatory mediators."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/648","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CINALUKAST","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:02:49.613872","biosimilars":[],"competitors":[{"drugName":"clotrimazole","drugSlug":"clotrimazole","fdaApproval":"1975-02-03","patentExpiry":"May 26, 2042","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"diethylstilbestrol","drugSlug":"diethylstilbestrol","fdaApproval":"1973-05-30","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"montelukast","drugSlug":"montelukast","fdaApproval":"1998-02-20","genericCount":30,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"zafirlukast","drugSlug":"zafirlukast","fdaApproval":"1996-09-26","genericCount":4,"patentStatus":"Off-patent — generic available","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"cinalukast","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"clotrimazole","brandName":"clotrimazole","genericName":"clotrimazole","approvalYear":"1975","relationship":"same-target"},{"drugId":"diethylstilbestrol","brandName":"diethylstilbestrol","genericName":"diethylstilbestrol","approvalYear":"1973","relationship":"same-target"},{"drugId":"montelukast","brandName":"montelukast","genericName":"montelukast","approvalYear":"1998","relationship":"same-target"},{"drugId":"zafirlukast","brandName":"zafirlukast","genericName":"zafirlukast","approvalYear":"1996","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"5E1O433QAI","CHEBI":"CHEBI:126598","INN_ID":"7094","UMLSCUI":"C0287390","ChEMBL_ID":"CHEMBL283754","KEGG_DRUG":"D02846","DRUGBANK_ID":"DB00587","PUBCHEM_CID":"6436135","MESH_SUPPLEMENTAL_RECORD_UI":"C071436"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":10,"therapeuticAreas":["Immunology"],"biosimilarFilings":[],"recentPublications":[{"date":"2024 Oct 1","pmid":"38895744","title":"Azologs of the Fatty Acid Mimetic Drug Cinalukast Enable Light-Induced PPARα Activation.","journal":"ChemMedChem"},{"date":"2023 Jul-Aug","pmid":"35751129","title":"In-silico discovery of inhibitors against human papillomavirus E1 protein.","journal":"Journal of biomolecular structure & dynamics"},{"date":"2020 May 21","pmid":"32179525","title":"MK-571, a Cysteinyl Leukotriene Receptor 1 Antagonist, Inhibits Hepatitis C Virus Replication.","journal":"Antimicrobial agents and chemotherapy"},{"date":"2019 Jul 17","pmid":"31141287","title":"Computer-Assisted Selective Optimization of Side-Activities-from Cinalukast to a PPARα Modulator.","journal":"ChemMedChem"},{"date":"2013 Nov","pmid":"23859232","title":"A review on leukotrienes and their receptors with reference to asthma.","journal":"The Journal of asthma : official journal of the Association for the Care of Asthma"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}